Cationic polyrotaxanes effectively inhibit uptake via carnitine/organic cationic transporters without cytotoxicity

Macromolecular Bioscience

Volumn 8, Issue 7, 2008, Pages 665-669

  Utsunomiya, Hideto ^a   Katoono, Ryo ^a,b   Yui, Nobuhiko ^a,b   Sugiura, Tomoko ^c   Kubo, Yoshiyuki ^c   Kato, Yukio ^c   Tsuji, Akira ^c  

^a JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c KANAZAWA UNIVERSITY   (Japan)

Author keywords

Biocompatibility; Drug delivery systems; Inhibitors; Polyrotaxanes; Supramolecular structures; Surfaces; Transporters

Indexed keywords

BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; BIOCOMPATIBILITY; CELL MEMBRANES; CYCLODEXTRINS; ETHYLENE; ETHYLENE GLYCOL; GLYCOLS; POLYETHYLENE OXIDES; POSITIVE IONS;

DRUG-DELIVERY SYSTEMS; INHIBITORS; POLYROTAXANES; SUPRAMOLECULAR STRUCTURES; TRANSPORTERS;

POLYETHYLENE GLYCOLS;

ALPHA CYCLODEXTRIN DERIVATIVE; CARNITINE; CATION; MACROGOL; ORGANIC CATION TRANSPORTER 2; POLYCATION; POLYMER; POLYROTAXANE DERIVATIVE; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; ORGANIC CATION TRANSPORTER; ROTAXANE; SLC22A5 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; CATION TRANSPORT; CELL STRAIN HEK293; CELL SURFACE; CONTROLLED STUDY; CYTOTOXICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; CELL LINE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; TRANSPORT AT THE CELLULAR LEVEL;

ALPHA-CYCLODEXTRINS; BIOLOGICAL TRANSPORT; CARNITINE; CELL LINE; HUMANS; ORGANIC CATION TRANSPORT PROTEINS; POLYETHYLENE GLYCOLS; ROTAXANES;

EID: 54049144352     PISSN: 16165187     EISSN: 16165195     Source Type: Journal    
DOI: 10.1002/mabi.200700297     Document Type: Article

References (31)

1. [1a] K. Kataoka, A. Harada, Y. Nagasaki, Adv. Drug Delivery Rev. 2001, 47, 113;
2. [1b] A. Harada, K. Kataoka, Science 1999, 283, 65;
3. [1c] M. Mammen, S. K. Choi, G. M. Whitesides, Angew. Chem. Int. Ed. 1998, 37, 2754;
4. [1d] L. L. Kiessling, N. L. Pohl, Chem. Biol. 1996, 3, 71;
5. [1e] T. Hasegawa, S. Kondoh, K. Matsuura, K. Kobayashi, Macromolecules 1999, 32, 6595;
6. [1f] C. R. Bertozzi, L. L. Kiessling, Science 2001, 291, 2357;
7. [1g] J. J. Lundquist, E. J. Toone, Chem. Rev. 2002, 102, 555;
8. [1h] T. Motomu, S. Erich, Nature 2005, 437, 656.
9. N. Yui, "Supramolecular Design for Biological Applications", CRC Press, Boca Raton, FL 2002.
10. [3a] A. Harada, M. Kamachi, Macromolecules 1990, 23, 2821;
11. [3b] A. Harada, J. Li, M. Kamachi, Nature 1994, 370, 126;
12. [3c] A. Harada, M. Okada, J. Li, M. Kamachi, Macromolecules 1995, 28, 8406;
13. [3d] A. Harada, J. Li, M. Kamachi, Nature 1992, 356, 325.
14. [4a] T. Ooya, M. Eguchi, N. Yui, J. Am. Chem. Soc. 2003, 125, 13016;
15. [4b] T. Ooya, H. Utsunomiya, M. Eguchi, N. Yui, Bioconjugate Chem. 2005, 16, 62;
16. [4c] T. Ooya, N. Yui, J. Controlled Release 2002, 80, 219.
17. [5a] N. Yui, T. Ooya, Chemistry 2006, 12, 6730;
18. [5b] N. Yui, T. Ooya, J. Artif. Organs 2004, 7, 62.
19. [6a] A. Tsuji, Yakugaku Zasshi 2002, 122, 1037;
20. [6b] A. Anzai, K. Yoshikatsu, E. Hitoshi, J. Pharmacol. Sci. 2006, 100, 411.
21. J. E. Gestwicki, C. W. Cairo, L. E. Strong, K. A. Oetjen, L. L. Kiessling, J. Am. Chem. Soc. 2002, 124, 14922.
22. N. Yui, T. Ooya, T. Kawashima, Y. Saito, I. Tamai, Y. Sai, A. Tsuji, Bioconjugate Chem. 2002, 13, 582.
23. [9a] R. Ohashi, I. Tamai, H. Yabuuchi, J. Nezu, A. Oku, Y. Sai, M. Shimane, A. Tsuji, J. Pharmacol. Exp. Ther. 1999, 291, 778;
24. [9b] I. Tamai, R. Ohashi, J. Nezu, Y. Sai, D. Kobayashi, A. Oku, M. Shimane, A. Tsuji, J. Biol. Chem. 2000, 275, 40064.
25. [10a] C. Pugh, J. Y. Bae, J. R. Scott, C. L. Wilkins, Macromolecules 1997, 30, 8139;
26. [10b] K. M. Huh, T. Ooya, W. K. Lee, S. Sasaki, I. C. Kwon, S. Y. Jeong, N. Yui, Macromolecules 2001, 34, 8657.
27. A. Yamashita, N. Yui, T. Ooya, A. Kano, A. Maruyama, H. Akita, K. Kogure, H. Harashima, Nat. Protoc. 2006, 1, 2861.
28. [12a] Y. Kato, Y. Sai, K. Yoshida, C. Watanabe, T. Hirata, A. Tsuji, Mol. Pharmacology 2005, 67, 734;
29. [12b] T. Sugiura, Y. Kato, Y. Kubo, A. Tsuji, Drug Meta. Pharmacokinet. 2006, 21, 375.
30. Y. Kato, K. Yoshida, C. Watanabe, Y. Sai, A. Tsuji, Pharm. Res. 2004, 21, 1886.
31. T. Mosmann, J. Immunol. Methods 1983, 65, 55.