Multivalent interactions between biotin-polyrotaxane conjugates and streptavidin as a model of new targeting for transporters

Journal of Controlled Release

Volumn 80, Issue 1-3, 2002, Pages 219-228

  Ooya, Tooru ^a   Yui, Nobuhiko ^a  

^a JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

Conjugate; Kinetics; Multivalent ligands; Polyrotaxanes; Surface plasmon resonance

Indexed keywords

BIOTIN; CYCLODEXTRIN; MACROGOL; POLYROTAXANE; STREPTAVIDIN; TAXANE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DISSOCIATION; DRUG PROTEIN BINDING; DRUG TARGETING; EQUILIBRIUM CONSTANT; LIGAND BINDING; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; THEORETICAL MODEL;

BIOTIN; DRUG DELIVERY SYSTEMS; DRUG INTERACTIONS; INDICATORS AND REAGENTS; MEMBRANE TRANSPORT PROTEINS; MODELS, CHEMICAL; ROTAXANES; STREPTAVIDIN;

EID: 0037161327     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00030-5     Document Type: Article

References (29)

1. Water soluble polymers in tumor targeted delivery
2. Polymerizable Fab' antibody fragments for targeting of anticancer drugs
3. Biorecognition of HPMA copolymer-adriamycin conjugates by lymphocytes mediated by synthetic receptor binding epitopes
4. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics
5. Receptor-mediated gene transfer by phage-display vectors: Applications in functional genomics and gene therapy
6. 2-targeted conjugates and combined therapy with immunomodulators
7. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
8. Multi-valent polymer of vancomycin: Enhanced antibacterial activity against VRE
9. Targeting the sodium-dependent multivitamin transporter (SMVT) for improving the oral absorption properties of a retro-inverso Tat nonapeptide
10. Direct evidence for a peptide transporter (PepT1)-mediated uptake of a nonapeptide prodrug valacyclovir
11. Characterization of the oral absorption of beta-lactam antibiotics. II. Competitive absorption and peptide carrier specificity
12. Carrier-mediated approaches for oral drug delivery
13. Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter
14. Synthesis and characterization of biodegradable polyrotaxane as a novel supramolecular-structured drug carrier
15. Synthesis and characterization of an oligopeptide-terminated polyrotaxane as a drug carrier
16. Enhanced accessibility of peptide substrate toward a membrane-bound metalloexopeptidase by supramolecular structure of polyrotaxane
17. Controllable erosion time and profile in poly(ethylene glycol) hydrogels by supramolecular structure of hydrolyzable polyrotaxane
18. Targeting the intestinal biotin transporter to enhance the permeability of peptides and their biopolymeric conjugates
19. Synthesis of polyrotaxane-biotin conjugates and surface plasmon resonance analysis of streptavidin recognition
20. Surface plasmon resonance analysis of dynamic biological interactions with biomaterials
21. Probing low affinity and multivalent interactions with surface plasmon resonance: Ligand for concanavarin A
22. Effects of solute multivalence on the evaluation of binding constants by biosensor technology: Studies with concanavalin A and interleukin-6 as partitioning protein
23. Polyvalent interactions in biological systems: Implications for design and use of multivalent ligands and inhibitors
24. Energy entropy and the reaction coordinate: Thermodynamic-like relations in chemical kinetics
25. Hydrophobic effects. Opinions and facts
26. The affinity of antibody: Range, variability and the role of multivalence
27. Real-time competitive kinetic analysis of interactions between low-molecular-weight ligands in solution and surface-immobilized receptors
28. Polyacrylamides bearing pendant α-sialoside groups strongly inhibit agglutination of erythrocytes by influenza virus: The strong inhibition reflects enhanced binding through cooperative polyvalent interactions
29. Avidin