Protein disulfide isomerase has no stimulatory chaperone effect on factor X activation by factor VIIa-soluble tissue factor

Thrombosis Research

Volumn 123, Issue 1, 2008, Pages 171-176

  Persson, Egon ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Factor VIIa; Factor X activation; Gla domain; Protein disulfide isomerise; Tissue factor

Indexed keywords

4 CARBOXYGLUTAMIC ACID; BLOOD CLOTTING FACTOR 10; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 7A; CHAPERONE; LIPOCORTIN 5; PHOSPHOLIPID; PROTEIN DISULFIDE ISOMERASE;

ARTICLE; CONTROLLED STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; CATTLE; FACTOR VIIA; FACTOR X; HUMANS; MAGNESIUM; PROTEIN DISULFIDE-ISOMERASES; PROTEIN STRUCTURE, TERTIARY; THROMBOPLASTIN;

EID: 54049143232     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2008.04.012     Document Type: Article

References (25)

1. Monroe D.M., and Key N.S. The tissue factor-factor VIIa complex: procoagulant activity, regulation, and multitasking. J Thromb Haemost 5 (2007) 1097-1105
2. Gruber C.W., Čemažar M., Heras B., Martin J.L., and Craik D.J. Protein disulfide isomerase: the structure of oxidative folding. Trends Biochem Sci 31 (2006) 455-464
3. Hatahet F., and Ruddock L.W. Substrate recognition by the protein disulfide isomerases. FEBS J 274 (2007) 5223-5234
4. Chen V.M., Ahamed J., Versteeg H.H., Berndt M.C., Ruf W., and Hogg P.J. Evidence for activation of tissue factor by an allosteric disulfide bond. Biochemistry 45 (2006) 12020-12028
5. Ahamed J., Versteeg H.H., Kerver M., Chen V.M., Mueller B.M., Hogg P.J., et al. Disulfide isomerization switches tissue factor from coagulation to cell signaling. Proc Natl Acad Sci USA 103 (2006) 13932-13937
6. Reinhardt C., von Brühl M.L., Manukyan D., Grahl L., Lorenz M., Altmann B., et al. Protein disulfide isomerase acts as an injury response signal that enhances fibrin generation via tissue factor activation. J Clin Invest 118 (2008) 1110-1122
7. Pendurthi U.R., Ghosh S., Mandal S.K., and Rao L.V.M. Tissue factor activation: is disulfide bond switching a regulatory mechanism?. Blood 110 (2007) 3900-3908
8. Versteeg H.H., and Ruf W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. J Biol Chem 282 (2007) 25416-25424
9. Thim L., Bjoern S., Christensen M., Nicolaisen E.M., Lund-Hansen T., Pedersen A.H., et al. Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells. Biochemistry 27 (1988) 7785-7793
10. Sakai T., Lund-Hansen T., Thim L., and Kisiel W. The γ-carboxyglutamic acid domain of human factor VIIa is essential for its interaction with cell surface tissue factor. J Biol Chem 265 (1990) 1890-1894
11. Nicolaisen E.M., Petersen L.C., Thim L., Jacobsen J.K., Christensen M., and Hedner U. Generation of Gla-domainless FVIIa by cathepsin G-mediated cleavage. FEBS Lett 306 (1992) 157-160
12. 2+ and tissue factor studied using circular dichroism spectroscopy. Protein Sci 5 (1996) 1531-1540
13. Morita T., and Jackson C.M. Preparation and properties of derivatives of bovine factor X and factor Xa from which the γ-carboxyglutamic acid containing domain has been removed. J Biol Chem 261 (1986) 4015-4023
14. Persson E., and Nielsen L.S. Site-directed mutagenesis but not γ-carboxylation of Glu-35 in factor VIIa affects the association with tissue factor. FEBS Lett 385 (1996) 241-243
15. Persson E., Nielsen L.S., and Olsen O.H. Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor. Biochemistry 40 (2001) 3251-3256
16. Persson E., Kjalke M., and Olsen O.H. Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity. Proc Natl Acad Sci USA 98 (2001) 13583-13588
17. Bajaj S.P., Schmidt A.E., Agah S., Bajaj M.S., and Padmanabhan K. High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor. J Biol Chem 281 (2006) 24873-24888
18. 2+ binding to the Gla domain of factor X influences the interaction with tissue factor. J Thromb Haemost 5 (2007) 1977-1978
19. Persson E. Characterization of the interaction between the light chain of factor VIIa and tissue factor. FEBS Lett 413 (1997) 359-363
20. 2+-free Gla domain sheds light on membrane binding of blood coagulation proteins. Nat Struct Biol 2 (1995) 504-509
21. Freedman S.J., Blostein M.D., Baleja J.D., Jacobs M., Furie B.C., and Furie B. Identification of the phospholipid binding site in the vitamin K-dependent blood coagulation protein factor IX. J Biol Chem 271 (1996) 16227-16236
22. Falls L.A., Furie B.C., Jacobs M., Furie B., and Rigby A.C. The ω-loop region of the human prothrombin γ-carboxyglutamic acid domain penetrates anionic phospholipid membranes. J Biol Chem 276 (2001) 23895-23902
23. Grant M.A., Baikeev R.F., Gilbert G.E., and Rigby A.C. Lysine 5 and phenylalanine 9 of the factor IX ω-loop interact with phosphatidylserine in a membrane-mimetic environment. Biochemistry 43 (2004) 15367-15378
24. Kothari H., Sen P., Pendurthi U., and Rao L.V.M. Bovine protein disulfide isomerase-enhanced tissue factor coagulant function: is phospholipid contaminant in it the real culprit?. Blood 111 (2008) 3295-3296
25. Cho J., Furie B.C., Coughlin S.R., and Furie B. A critical role for extracellular protein disulfide isomerase during thrombus formation in mice. J Clin Invest 118 (2008) 1123-1131