A glimmer of light for neuropsychiatric disorders

Nature

Volumn 455, Issue 7215, 2008, Pages 890-893

  Hyman, Steven E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA;

BIOMARKER; NERVOUS SYSTEM DISORDER; NEUROLOGY; PATHOGENICITY; PSYCHOLOGY; RISK ASSESSMENT;

AUTISM; BIPOLAR DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; MAJOR DEPRESSION; PHENOTYPE; PRIORITY JOURNAL; PSYCHOPATHY; REVIEW; SCHIZOPHRENIA;

EID: 54049119627     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07454     Document Type: Review

References (48)

1. Kessler, R. C., Chiu, W. T., Demler, O., Merikangas, K. R. & Walters, E. E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 62, 617-627 (2005).
2. Kessler, R. C. et al. Prevalence and treatment of mental disorder, 1990 to 2003. N. Engl. J. Med. 352, 2515-2513 (2005).
3. Murray, C. J. & Lopez, A. D. The Global Burden of Disease (Harvard Univ. Press, 1996).
4. World Health Organization. World Health Report 2001 (WHO, 2001).
5. Nestler, E. J., Hyman, S. E. & Malenka, R. J. Molecular Neuropharmacology: Foundation for Clinical Neuroscience 2nd edn (McGraw-Hill, 2008).
6. Kendler, K. S., Davis, C. G. & Kessler, R. C. The familial aggregation of common psychiatric and substance use disorders in the National Comorbidity Survey: a family history study. Br. J. Psychiatry 170, 541-548 (1997).
7. Craddock, N., O'Donovan, M. C. & Owen, M. J. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 42, 193-204 (2005).
8. Hyman, S. E. Can neuroscience be integrated into the DSM-V? Nature Rev. Neurosci. 8, 725-732 (2007).
9. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn, text revision (American Psychiatric Association, 2000).
10. Freitag, C. M. The genetics of autistic disorders and its clinical relevance: a review of the literature. Mol. Psychiatry 12, 2-22 (2007).
11. Sullivan, P. F., Kendler, K. S. & Neale, M. C. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch. Gen. Psychiatry 60, 1187-1192 (2003).
12. Merikangas, K. R. & Risch, N. Will the genomics revolution revolutionize psychiatry? Am. J. Psychiatry 160, 625-635 (2003).
13. Merikangas, K. R. & Risch, N. Genomic priorities and public health. Science 302, 599-601 (2003).
14. Kendler, K. S., Gatz, M., Gardner, C. O. & Pederson, N. L. A Swedish national twin study of lifetime major depression. Am. J. Psychiatry 163, 109-114, (2006).
15. Hardy, J. A hundred years of Alzheimer's disease research. Neuron 52, 3-13 (2006).
16. St. Clair, D. et al. Association within a family of a balanced autosomal translocation with major mental illness. Lancet 336, 13-16 (1990).
17. Hennah, W. et al. DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder. Mol. Psychiatry advance online publication, doi:10.1038/mp.2008.22 (4 March 2008).
18. Pacione, L. R., Szego, M. J., Ikeda, S., Nishina, P. M. & McInnes, R. R. Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations. Annu. Rev. Neurosci. 26, 657-700 (2003).
19. Hunter, D. J., Altshuler, D. & Rader, D. J. From Darwin's finches to canaries in the coal mine - mining the genome for new biology. N. Engl. J. Med. 358, 2760-2763 (2008).
20. Strittmatter, W. J. et al. Apoliprotein E: high avidity binding to β-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl Acad. Sci. USA 90, 1977-1981 (1993).
21. Edwards, A. O. et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419-421 (2005).
22. Zeggini, E. et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nature Genet. 40, 638-645 (2008).
23. Easton, D. F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087-1093 (2007).
24. Ciardiello, F. & Tortora, G. EGFR antagonists in cancer treatment. N. Engl. J. Med. 358, 1160-1174 (2008).
25. Chobanian, A. V. et al. National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 42, 1206-1252 (2003).
26. Millar, J. K. et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Gen. 9, 1415-1423 (2000).
27. Kendler, K. S. & Gardner, C. O. Jr. Boundaries of major depression: an evaluation of DSM-IV criteria. Am. J. Psychiatry 155, 172-177 (1998).
28. Ferreira, M. A. R. et al. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nature Genet. 40, 1056-1058 (2008).
29. O'Donovan, M. C. et al. Identification of loci associated with schizophrenia by genomewide association and follow-up. Nature Genet. 40, 1053-1055 (2008).
30. Chahrour, M. & Zoghbi, H. Y. The story of Rett syndrome: from clinic to neurobiology. Neuron 56, 422-437 (2007).
31. Reddy, K. S. Cytogenetic abnormalities and fragile-X syndrome in autism spectrum disorders. BMC Med. Genet. 6, 3-19 (2005).
32. Lewis, J., Thomas, H., Murphy, K. & Sampson, J. Genotype and psychological phenotype in tuberous sclerosis. J. Med. Genet. 41, 203-207 (2004).
33. Williams, N. M., O'Donovan, M. C. & Owen, M. J. Chromosome 22 deletion syndrome and schizophrenia. Int. Rev. Neurobiol. 73, 1-27 (2006).
34. Kobrynski, L. J. & Sullivan, K. E. Velocardiofacial syndrome, DiGeorge syndrome: the chromosome 22q11.2 deletion syndromes. Lancet 370, 1443-1452 (2007).
35. Veenstra-Vanderweele, J., Christian, S. L. & Cook, E. H. Jr. Autism as a paradigmatic complex genetic disorder. Annu. Rev. Genomics Hum. Genet. 5, 379-405 (2004).
36. Waring, S. C. & Rosenberg, R. N. Genome-wide association studies in Alzheimer disease. Arch. Neurol. 65, 329-334 (2008).
37. Farrer, M. J. Genetics of Parkinson disease: paradigm shifts and future prospects. Nature Rev. Genet. 7, 306-318 (2006).
38. Valdmanis, P. N. & Rouleau, G. A. Genetics of familial amyotrophic lateral sclerosis. Neurology 70, 144-152 (2008).
39. Walsh, T. et al. Rare structural variants disrupt multiple genes in neurodevelopmental pathways in schizophrenia. Science 320, 539-543 (2008).
40. Xu, B. et al. Strong association of de novo copy number mutations with sporadic schizophrenia. Nature Genet. 40, 880-885 (2008).
41. The International Schizophrenia Consortium. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455, 237-241 (2008).
42. Weiss, L. A. et al. Association between microdeletion and microduplication at 16p11.2 and autism. N. Engl. J. Med. 358, 667-675 (2008).
43. Morrow, E. M. et al. Identifying autism loci and genes by tracing recent shared ancestry. Science 321, 218-223 (2008).
44. Redon, R. et al. Global variation in copy number in the human genome. Nature 444, 444-454 (2006).
45. Gotz, J. & Ittner, L. M. Animal models of Alzheimer's disease and frontotemproal dementia. Nature Rev. Neurosci. 9, 532-544 (2008).
46. Watase, K. & Zoghbi, H. Y. Modelling brain diseases in mice: the challenges of design and analysis. Nature Rev. Genet. 4, 296-307 (2003).
47. Amir, R. E. et al. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG binding protein 2. Nature Genet. 23, 185-188 (1999).
48. Egeland, J. A. et al. Bipolar affective disorders linked to DNA markers on chromosome 11. Nature 325, 783-787 (1987).