Endotoxemia causes central downregulation of sympathetic vasomotor tone in healthy humans

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 295, Issue 3, 2008, Pages

  Sayk, Friedhelm ^a   Vietheer, Alexander ^a   Schaaf, Bernhard ^a   Wellhoener, Peter ^a   Weitz, Gunther ^a   Lehnert, Hendrik ^a   Dodt, Christoph ^a,b  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b Chirurgische Klinik Munchen Bogenhausen   (Germany)

Author keywords

Baroreceptors; Endotoxin; MSNA; Nervous system; Sympathetic; Systemic inflammation

Indexed keywords

CATECHOLAMINE; CYTOKINE; ENDOTOXIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITROPRUSSIDE SODIUM; PHENYLEPHRINE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; VASOACTIVE AGENT;

ADULT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE MONITORING; BLOOD PRESSURE REGULATION; BODY WEIGHT; CATECHOLAMINE BLOOD LEVEL; CORONARY BLOOD VESSEL; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG INFUSION; ENDOTOXEMIA; FLU LIKE SYNDROME; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; MEASUREMENT; MUSCLE CONTRACTION; NERVE CONDUCTION; NORMAL HUMAN; POSTSYNAPTIC POTENTIAL; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; SEPSIS; SYMPATHETIC TONE; VOLUNTEER; ADRENERGIC SYSTEM; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; IMMUNOLOGY; INFLAMMATION; INNERVATION; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; VASCULARIZATION;

ADULT; BLOOD PRESSURE; DOWN-REGULATION; ENDOTOXEMIA; HEART RATE; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MALE; MUSCLE, SKELETAL; PLACEBOS; PRESSORECEPTORS; SYMPATHETIC NERVOUS SYSTEM; TUMOR NECROSIS FACTOR-ALPHA; VASOMOTOR SYSTEM;

EID: 54049103595     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90444.2008     Document Type: Article

References (40)

1. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101: 3765-3777, 2003.
2. Annane D, Trabold F, Sharshar T, Jarrin I, Blanc AS, Raphael JC, Gajdos P. Inappropriate sympathetic activation at onset of septic shock-a spectral analysis approach. Am J Respir Crit Care Med 160: 458-465, 1999.
3. Bond RF. Peripheral vascular adrenergic depression during hypotension induced by E. coli endotoxin. Adv Shock Res 9: 157-169, 1983.
4. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkena GI, Watkins LR, Wang H, Abumrad N, Eaton JE, Tracey KJ. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405: 458-462, 2000.
5. Chan JY, Wang LL, Ou CC, Chan SH. Downregulation of angiotensin subtype 1 receptor in rostral ventrolateral medulla during endotoxemia. Hypertension 42: 103-109, 2003.
6. Chrousos GP, Kino T. Interactive functional specificity of the stress and immune responses: the ying, the yang, and the defense against 2 major classes of bacteria. J Infect Dis 192: 551-555, 2005.
7. Cohen J. The immunopathogenesis of sepsis. Nature 420: 891, 2002.
8. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 52: 595-638. 2000.
9. Esler MD, Jennings G, Lambert E, Metz CN, Hornyak M, Eisenhofer G. Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev 70: 963-985, 1990.
10. Fagius J, Karhuvaara S. Sympathetic activity and blood pressure increases with bladder distension in humans. Hypertension 14: 511-517, 1989.
11. Godin PJ, Fleisher LA, Eidsath A, Vandivier W, Preas HL, Banks SM, Buchman TG, Suffredini AF. Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial. Crit Care Med 24: 1117-1124, 1996.
12. Heindl S, Struck J, Wellhoener JP, Sayk F, Dodt C. Effect of facial cooling and cold air inhalation on sympathetic nerve activity in men. Resp Physiol Neurobiol 142: 69-80, 2004.
13. Hershey JC, Bond RF. Endotoxin induces metabolic dysregulation of vascular tone. Am J Physiol Heart Circ Physiol 265: H108-H113, 1993.
14. Izzo JL, Taylor AA. The sympathetic nervous system and baroreflexes in hypertension and hypotension. Curr Hypertens Rep 1: 254-263, 1999.
15. Knardahl S, Elam M, Olausson B, Wallin BG. Sympathetic nerve activity after acupuncture in humans. Pain 75: 19-25, 1998.
16. Korach M, Sharshar T, Jarrin I, Fouillot JP, Raphael JC, Gajdos P, Annane D. Cardiac variability in critically ill adults: influence of sepsis. Crit Care Med 29: 1380-1385, 2001.
17. Leinhardt DJ, Arnold J, Shipley KA, Mughal MM, Little RA, Irving MH. Plasma NE concentrations do not accurately reflect sympathetic nervous system activity in human sepsis. Am J Physiol Endocrinol Metab 265: E284-E288, 1993.
18. Macarthur H, Westfall TC, Riley DP, Misko TP, Salvemini D. Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock. Proc Natl Acad Sci USA 97: 9753-9758, 2000.
19. Niijima A, Hori T, Aou S, Oomura Y. The effects of interleukin-1β on the activity of adrenal, splenic and renal sympathetic nerves in the rat. J Auton Nerv Syst 36: 183-192, 1991.
20. Opal SM. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int J Med Microbiol 297: 365-377, 2007.
21. Parrillo JE, Parker MM, Natanson C, Suffredini AF, Danner RL, Cunnion RE, Ognibene FP. Septic shock in humans-advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy. Ann Int Med 113: 227-242, 1990.
22. Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 9: 125-134, 2003.
23. Pickkers P, Dorresteijn MJ, Bouw MP, van der Hoeven JG, Smits P. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation 114: 414-421, 2006.
24. Preas HL, Jurban A, Vandivier W, Reda D, Godin PJ, Banks SM, Tobin MJ, Suffredini AF. Effect of endotoxin on ventilation and breath variability-role of cyclooxygenase pathway. Am J Respir Crit Care Med 164: 620-626, 2001.
25. Rassias AJ, Holzberger PT, Givan AL, Fahmer SL, Yeager MP. Decreased physiologic variability as a generalized response to human endotoxemia. Crit Care Med 33: 519, 2005.
26. Rogausch H, del Rey A, Kabiersch A, Reschke J, Örtel J, Besedowsky HO. Endotoxin impedes vasoconstriction in the spleen: role of endogenous interleukin-1 and sympathetic innervation. Am J Physiol Regul Integr Comp Physiol 272: R2048-R2054, 1997.
27. Rogausch H, Vo NT, del Rey A, Besedowsky HO. Increased sensitivity of the baroreceptor reflex after bacterial endotoxin. Ann NY Acad Sci 917: 165-168, 2000.
28. Sayk F, Becker C, Teckentrup C, Fehm HL, Struck J, Wellhoener JP, Dodt C. To dip or not to dip. On the physiology of blood pressure decrease during nocturnal sleep in healthy humans. Hypertension 49: 1070-1076, 2007.
29. Sharshar T, Gray F, Lorin de la Grandmaison G, Hopkinson NS, Ross E, Dorandeu A, Orlikowski D, Raphael JC, Gajdos P, Annane D. Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock. Lancet 362: 1799-1805, 2003.
30. Straub RH, Pongratz G, Weidler C, Linde HJ, Kirschnig CJ, Glück T, Schölmerich J, Falk W. Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. J Infect Dis 192: 560 -572, 2005.
31. Suffredini AF, Fromm RE, Parker MM, Brenner M, Kovacs JA, Wesley RA, Parrillo JE. The cardiovascular response of normal humans to the administration of endotoxin. N Engl J Med 321: 280 -287, 1989.
32. Suffredini AF, Hochstein HD, McMahon FG. Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. J Infect Dis 179: 1278-1282, 1999.
33. Task Force of the ESC and North American Society of Pacing and Electrophysiology. Heart rate variability, standards of measurement, physiological interpretation, and clinical use. Circulation 93: 1043-1065, 1996.
34. Tracey KJ, Lowry SF, Cerami A. Cachectin: a hormone that triggers acute shock and chronic cachexia. J Infect Dis 157: 413-420, 1998.
35. Vallbo AB, Hagbarth KE, Torebjörk HE, Wallin BG. Somatosensory, proprioceptive, and sympathetic activity in human peripheral nerves. Physiol Res 59: 919-957, 1979.
36. Vayssettes-Courchay C, Bouysset F, Verbeuren TJ. Sympathetic activation and tachycardia in lipopolysaccharide treated rats are temporally correlated and unrelated to the baroreflex. Auton Neurosci 120: 35- 45, 2005.
37. Vincent JL, Zhang H, Szabo C, Preiser JC. Effects of nitric oxide in septic shock. Am J Respir Crit Care Med 161: 1781-1785, 2000.
38. Voss LJ, Bolton DPG, Galland BC, Taylor BJ. Endotoxin effects on markers of autonomic nervous system function in the piglet: implications for SIDS. Biol Neonate 86: 39-47, 2004.
39. Wu R, Zhou M, Das P, Dong W, Ji Y, Yang D, Miksa M, Zhang F, Ravikumar TS, Wang P. Ghrelin inhibits sympathetic nervous activity in sepsis. Am J Physiol Endocrinol Metab 293: E1697-E1702, 2007.
40. Zhou ZZ, Wurster RD, Jones SB. Arterial baroreflexes are not essential in mediating sympathoadrenal activation in conscious endotoxic rats. J Auton Nerv Syst 39: 1-12, 1992.