Preparative chromatographic resolution of racemates using HPLC and SFC in a pharmaceutical discovery environment

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 875, Issue 1, 2008, Pages 230-236

  Miller, Larry ^a   Potter, Matt ^a  

^a AMGEN INC   (United States)

Author keywords

Chiral separations; Chiral stationary phase; Preparative chromatography; Supercritical fluid chromatography

Indexed keywords

CHIRALITY; CHROMATOGRAPHY; EFFLUENT TREATMENT; ENANTIOMERS; GAS CHROMATOGRAPHY; INDUSTRIAL WASTE TREATMENT; SEPARATION; SUPERCRITICAL FLUIDS;

CASE STUDIES; CHIRAL SEPARATIONS; CHIRAL STATIONARY PHASE; CHIRAL STATIONARY PHASIS; CHROMATOGRAPHIC RESOLUTIONS; METHOD DEVELOPMENTS; PHARMACEUTICAL DISCOVERIES; PREPARATIVE CHROMATOGRAPHY; PREPARATIVE HPLC; SUPERCRITICAL FLUID CHROMATOGRAPHY;

CHROMATOGRAPHIC ANALYSIS;

SOLVENT;

ARTICLE; CHIRALITY; CHROMATOGRAPHY; DRUG RESEARCH; ENANTIOMER; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; RACEMIC MIXTURE; SUPERCRITICAL FLUID CHROMATOGRAPHY; TEMPERATURE;

AMYLOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DRUG DISCOVERY; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PHENYLCARBAMATES; STEREOISOMERISM;

EID: 54049095866     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.06.044     Document Type: Article

References (26)

1. Brocks D.R., Pasutto F.M., and Jamali F. J. Chromatogr. 581 (1992) 83
2. Francotte E.R. Switz. Chim. 51 10 (1997) 717
3. Francotte E. Preparative Enantioselective Chromatography (2005), Blackwell Publishing
4. Miller L., Honda D., Fronek R., and Howe K. J. Chromatogr. A 658 (1994) 429
5. Francotte E.R. In: Ahuga S. (Ed). Switz Chiral Sep (1997), American Chemical Society 271
6. Miller L., and Bush H. J. Chromatogr. 484 (1989) 337
7. Miller L., and Weyker C. J. Chromatogr. 511 (1990) 97
8. Andersson S. Chiral Separation Techniques. 3rd edition (2007), Wiley-VCH
9. Welch C.J., Leonard Jr. W.R., Dasilva J.O., Biba M., Albaneze-Walker J., Headerson D.W., Liang B., and Mathre D.J. LC-GC N. Am. 23 1 (2005)
10. Toribio L., del Nozal M.J., Bernal J.L., Alonso C., and Jimenez J.J. J. Chromatogr. A 1091 (2005) 118
11. Phinney K.W. Anal. Bioanal. Chem. 381 (2005) 639
12. White C. J. Chromatogr. A 1074 (2005) 163
13. Maftouh M., Granier-Loyaux C., Chavana E., Marini J., Pradines A., Vander Heyden Y., and Picard C. J. Chromatogr. A 1088 (2005) 67
14. Barnhart W., Gahm K.H., Thomas S., Notari S., Semin D., and Cheetham J. J. Sep. Sci. 28 (2005) 619
15. Toribio L., Alonso C., del Nozal M.J., Bernal J.L., and Martin M.T. J. Chromatogr. A 1137 (2006) 30
16. Zhang T., and Franco P. Chiral Separation Techniques. 3rd edition (2007), Wiley-VCH
17. Yanik G.W. Chiral Separation Techniques. 3rd edition (2007), Wiley-VCH
18. Zeng L., Xu R., Laskar D.B., and Kassel D.B. J. Chroamtogr. A 1169 1-2 (2007) 193
19. M. J. Haywared, Q. Han, Abstracts of Papers, 234th ACS National Meeting, Boston, MA, USA, August 19-23, 2007.
20. Pinsktons D.J., Wen D., Morand K.L., Tirey D.A., and Stanton D.T. Anal. Chem. 78 21 (2006) 7467
21. Alexander A.J., and Staab A. Anal. Chem. 78 11 (2006) 3835
22. Bolanos B., Greig M., Ventura M., Farrell W., Aurigemman C.M., Li H., Quenzer T.L., Tivel K., Bylund J.M.R., Tran P., Pham C., and Phillipson D. Int. J. Mass Spectrom. 238 2 (2004) 85
23. D. J. Pinkston, M. L. Mangels, Abstract of Papers, 226th ACS National Meeting, New York, NJ, USA, September 7-11, 2003.
24. Coe R.A., Rathe J.O., and Lee J.W. J. Pharm. Biomed. Anal. 42 (2006) 573
25. Chen J., Hsieh Y., Cook J., Morrison R., and Korfmacher W.A. Anal. Chem. 78 4 (2006) 1212
26. Zhao Y., Woo G., Thomas S., Semin D., and Sandra P. J. Chroamtogr. A 1003 (2003) 157