Tissue-specific pyruvate dehydrogenase complex deficiency causes cardiac hypertrophy and sudden death of weaned male mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 3, 2008, Pages

  Sidhu, Sukhdeep ^a   Gangasani, Ashish ^a   Korotchkina, Lioubov G ^a   Suzuki, Gen ^a   Fallavollita, James A ^a,b   Canty Jr , John M ^a,b   Patel, Mulchand S ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b VA WESTERN NEW YORK HEALTHCARE SYSTEM   (United States)

Author keywords

High fat diet; Pdha1 gene deletion; Sudden death; Ventricular hypertrophy

Indexed keywords

GLUCOSE; LACTIC ACID; PYRUVATE DEHYDROGENASE COMPLEX;

ALPHA CHAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DECARBOXYLATION; ENERGY TRANSFER; ENZYME ACTIVITY; FEMALE; GLUCOSE METABOLISM; GLUCOSE OXIDATION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE; HEART VENTRICLE CONTRACTION; HEART VENTRICLE FUNCTION; HEART VENTRICLE HYPERTROPHY; HETEROZYGOTE; KNOCKOUT MOUSE; LIPID DIET; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY; SKELETAL MUSCLE; SUDDEN DEATH; SURVIVAL; TISSUE SPECIFICITY; WILD TYPE; ANIMAL; BODY WEIGHT; CARDIOMEGALY; CELL SIZE; DRUG EFFECT; ELECTROCARDIOGRAPHY; ENERGY METABOLISM; FAT INTAKE; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; METABOLISM; MOUSE MUTANT; ORGAN SIZE; OXIDATION REDUCTION REACTION; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BODY WEIGHT; CARDIOMEGALY; CELL SIZE; DEATH, SUDDEN; DIETARY FATS; ELECTROCARDIOGRAPHY; ENERGY METABOLISM; FEMALE; GLUCOSE; MALE; MICE; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; ORGAN SIZE; OXIDATION-REDUCTION; PYRUVATE DEHYDROGENASE COMPLEX; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VENTRICULAR DYSFUNCTION, LEFT;

EID: 54049093711     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00363.2008     Document Type: Article

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