Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development

Molecular Genetics and Metabolism

Volumn 74, Issue 3, 2001, Pages 293-302

  Johnson, Mark T ^b   Mahmood, Saleh ^a   Hyatt, Susannah L ^b   Yang, Hsin Sheng ^a   Soloway, Paul D ^c   Hanson, Richard W ^b   Patel, Mulchand S ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Cre loxP; Embryonic development; Mouse; Pdha1 gene disruption; Pyruvate dehydrogenase complex deficiency; X chromosome

Indexed keywords

CRE RECOMBINASE; GENE PRODUCT; GLUCOSE; PROTEIN PDHA1; PYRUVATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; EMBRYO RESORPTION; ENZYME ACTIVITY; ENZYME DEFICIENCY; EXON; FEMALE; GENE DISRUPTION; GENE INACTIVATION; GENE INSERTION; GLUCOSE METABOLISM; IN VITRO STUDY; IN VIVO STUDY; INTRON; LITTER SIZE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL; X CHROMOSOME;

MURINAE;

EID: 0035201701     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3249     Document Type: Article

References (32)

1. Molecular biology and biochemistry of pyruvate dehydrogenase complexes
2. Pyruvate dehydrogenase E1 α subunit genes in the mouse: Mapping and comparison with human homologues
3. A testis-specific form of the human pyruvate dehydrogenase E1 alpha subunit is coded for by an intronless gene on chromosome 4
4. Human defects of the pyruvate dehydrogenase complex
5. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting
6. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system
7. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development
8. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to nonselectable genes
9. Targeting E3 component of alpha-keto acid dehydrogenase complexes
10. Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting
11. Deficiency of the pyruvate dehydrogenase component in pyruvate dehydrogenase complex-deficient human fibroblasts
12. Systemic deficiency of the first component of the pyruvate dehydrogenase complex
13. Dihydrolipoamide dehydrogenase: Activity assays
14. Efficient in vivo manipulation of mouse genomic sequences at the zygote stage
15. Genetic control of ovulation rate and embryo survival in mice. I. Response to selection
16. Mutations and polymorphisms in the pyruvate dehydrogenase E 1 alpha gene
17. Sequence conservation in the alpha and beta subunits of pyruvate dehydrogenase and its similarity to branched-chain alpha-keto acid dehydrogenase
18. Demonstration of an unstable variant of pyruvate dehydrogenase protein (E1) in culture fibroblasts from a patient with congenital lactic acidemia
19. Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages
20. Transactivation of the adenovirus E1A protein is restricted to mouse oocytes and preimplantation embryos
21. Insulin-like growth factor-I affects perinatal lethality and postnatal development in a gene dosage-dependent manner: Using Cre/loxP system in transgenic mice
22. Cre-mediated germline mosaicism: A method allowing rapid generation of several alleles of a target gene
23. X inactivation and somatic cell selection rescue female mice carrying a Piganull mutation
24. X-linked pyruvate dehydrogenase E1 alpha subunit deficiency in heterozygous females: Variable manifestation of the same mutation
25. Glucose utilization by components of the mouse conceptus during early embryogenesis
26. Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis
27. Targeted disruption of the murine dihydrolipoamide dehydrogenase gene (Dld) results in perigastrulation lethality
28. Oxygen consumption and energy metabolism of the early mouse embryo
29. Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice
30. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis
31. Quantification of the transition from oocyte-encoded to embryo-encoded glucose phosphate isomerase in mouse embryos
32. Structural organization of the gene for the E1 alpha subunit of the human pyruvate dehydrogenase complexes