Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. I. Taxonomy, fermentation, isolation, and biological activities

Journal of Antibiotics

Volumn 60, Issue 9, 2007, Pages 547-553

  Tashiro, Etsu ^a   Hironiwa, Naoka ^a   Kitagawa, Mitsuhiro ^a   Futamura, Yushi ^a   Suzuki, Shin Ichi ^b   Nishio, Maki ^b   Imoto, Masaya ^a  

^a KEIO UNIVERSITY   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

ER stress; Triene ansamycin; Trierixin; XBP1

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; MYCOTRIENIN II PROTEIN; NITROBLUE TETRAZOLIUM; PROTEIN INHIBITOR; SILICA GEL; THAPSIGARGIN; TRIENOMYCIN PROTEIN; TRIERIXIN PROTEIN; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; ALANINE; ANTIINFECTIVE AGENT; DNA BINDING PROTEIN; DRUG DERIVATIVE; HYDROQUINONE DERIVATIVE; LUCIFERASE; MACROCYCLIC LACTAM; MYCOTRIENIN II; NUCLEAR PROTEIN; TRE BINDING PROTEIN; TRE-BINDING PROTEIN; TRIENOMYCIN A; TRIERIXIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BIOLOGICAL ACTIVITY; COLUMN CHROMATOGRAPHY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; FERMENTATION; HELA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SCREENING; STREPTOMYCES; TAXONOMY; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CLASSIFICATION; DRUG ANTAGONISM; DRUG EFFECT; ENDOPLASMIC RETICULUM; ISOLATION AND PURIFICATION; METABOLISM; PATHOPHYSIOLOGY; STRESS;

STREPTOMYCES SP.;

ALANINE; ANTI-BACTERIAL AGENTS; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM; FERMENTATION; HELA CELLS; HUMANS; HYDROQUINONES; INHIBITORY CONCENTRATION 50; LACTAMS, MACROCYCLIC; LUCIFERASES; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STREPTOMYCES; STRESS; THAPSIGARGIN;

EID: 38449110738     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.69     Document Type: Article

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