On the neural networks of empathy: A principal component analysis of an fMRI study

Behavioral and Brain Functions

Volumn 4, Issue , 2008, Pages

  Nomi, Jason S ^a,b   Scherfeld, Dag ^a   Friederichs, Skara ^a   Schäfer, Ralf ^a   Franz, Matthias ^a   Wittsack, Hans Jörg ^a   Azari, Nina P ^b   Missimer, John ^c   Seitz, Rüdiger J ^a,d,e  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY OF HAWAII AT HILO   (United States)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e Brain Imaging Center West   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; EMOTION; EMPATHY; FACIAL EXPRESSION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; NERVE CELL NETWORK; NORMAL HUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; RECOGNITION; VARIANCE; VOLUNTEER;

EID: 53949117358     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-4-41     Document Type: Article

References (107)

1. Leppanen JM Moulson MC Vogel-Farley VK Nelson CA An ERP study of emotional face processing in the adult and infant brain Child Develop 2007, 78:232-245 10.1111/j.1467-8624.2007.00994.x 17328702
2. Adolphs R Neural systems for recognizing emotion Curr Opin Neurobiol 2002, 12:169-177 10.1016/S0959-4388(02)00301-X 12015233
3. Williams KR Wishart JG Pitcairn TK Willis DS Emotion recognition by children with Down syndrome: Investigation of specific impairments and error patterns Am J Ment Retard 2005, 110:378-392 10.1352/ 0895-8017(2005)110[378:ERBCWD]2.0.CO;2 16080776
4. Blair RJR Facial expressions, their communicatory functions and neuro-cognitive substrates Phil Trans R Soc Lond 2003, 358:561-572 10.1098/rstb.2002.1220
5. Eimer M Homes A An ERP study on the time course of emotional face processing NeuroReport 2002, 13:1-5 10.1097/00001756-200203250-00013 11924867
6. Ruby R Decety J What you believe versus what you think they believe: A neuroimaging study of conceptual perspective-taking Eur J Neurosci 2003, 17:2475-2480 10.1046/j.1460-9568.2003.02673.x 12814380
7. Fonagy P Gergely G Jurist EL Affect Regulation, Mentalization, and the Development of the Self John Wiley & Sons. New York 2005
8. Decety J Lamm C Human empathy through the lens of social neuroscience Scientific World Journal 2006, 6:1146-1163 10.1100/tsw.2006.221 16998603
9. Preston SD de Waal FBM Empathy: Its ultimate and proximate bases Behav Brain Sci 2002, 25:1-72 12625087
10. Iacoboni M Molnar-Szakacs I Gallese V Buccino G Mazziotta JC Rizzolatti G Grasping the intentions of others with one's own mirror neuron system PLoS Biology 2005, 3:e79 0529-0535 1044835 15736981 10.1371/ journal.pbio.0030079
11. Jackson PL Brunet E Meltzoff AN Decety J Empathy examined through the neural mechanisms involved in imagining how I feel versus how you feel pain Neuropsychologia 2005, 44:752-761 10.1016/ j.neuropsychologia.2005.07.015 16140345
12. Calder AJ Young AW Understanding the recognition of facial identitiy and facial expression Nat Neurosci 2005, 6:641-651 10.1038/nrn1724
13. Haxby JV Gobbini MI Furey ML Ishai A Schouten JL Pietrini P Distributed and overlapping representations of faces and objects in ventral temporal cortex Science 2001, 293:2425-2430 10.1126/science.1063736 11577229
14. Posamentier MT Abdi H Processing faces and facial expressions Neuropsychol Rev 2003, 13:113-143 10.1023/A:1025519712569 14584908
15. Sinha P Balas B Ostrovsky Y Russell R Face recognition by humans: Nineteen results all computer vision researchers should know about IEEE 2006, 94:1948-1962 10.1109/JPROC.2006.884093
16. Crocker V McDonald S Recognition of emotion from facial expression following traumatic brain injury Brain Inj 2005, 19:787-799 10.1080/ 02699050500110033 16175839
17. Ashley V Vuilleumier P Swick D Time course and specificity of event-related poetentials to emotional expressions Neuroreport 2003, 15:211-216 10.1097/00001756-200401190-00041
18. Blau VC Maurer U Tottenham N McCandliss BD The face-specific N170 component is modulated by emotional facial expression Behav Brain Funct 2007, 3:7 1794418 17244356 10.1186/1744-9081-3-7
19. Liu J Harris A Kanwisher N Stages of processing in face perception: An MEG study Neuroscience 2002, 5:910-916 12195430
20. Kaufmann J Schweinberger SR Expression influences the recognition of familiar faces Perception 2004, 33:399-408 10.1068/p5083 15222388
21. Gallese V Keysers C Rizzolatti G A unifying view of the basis of social cognition Trends Cogn Sci 2004, 8(9):396-403 10.1016/j.tics.2004.07.002 15350240
22. Uddin LQ Molnar-Szakacs I Zaidel E Iacoboni M fTMS to the right inferior parietal lobule disrupts self-other discrimination Soc Cogn Affect Neurosci 2007, 1:65-71 10.1093/scan/nsl003
23. Schütz-Bosbach S Mancini B Aglioti SM Haggard P Self and other in the human motor system Curr Biol 2006, 16:1830-1834 10.1016/ j.cub.2006.07.048 16979561
24. Decety J Grezes J The power of simulation: Imagining one's own and other's behavior Brain Res 2006, 12:4-14 10.1016/j.brainres.2005.12.115
25. Seitz RJ Nickel J Azari NP Functional modularity of the medial prefrontal cortex: Involvement in human empathy Neuropsychology 2006, 20:743-751 10.1037/0894-4105.20.6.743 17100519
26. Decety J Jackson PL The functional architecture of Human Empathy Behav Cogn Neurosci Rev 2004, 3:71-100 10.1177/1534582304267187 15537986
27. Horwitz B Data analysis paradigms for metabolic-flow data: Combining neural modeling and functional neuroimaging Human Brain Mapp 1994, 2:112-122 10.1002/hbm.460020111
28. Alexander GE Moeller JR Application of the subprofile model to functional imaging in neuropsychiatric disorders: A principal component approach to modeling brain function in disease Human Brain Mapp 1994, 2;79-94 10.1002/hbm.460020108
29. Friston KJ Holmes AP Worsely KJ Poline J-P Frith CD Frackowiak RSJ Statistical parametric maps in functional imaging: A generalized linear approach Human Brain Mapp 1994, 2:189-210 10.1002/hbm.460020402
30. McIntosh AR Towards a network theory of cognition Neural Netw 2000, 13:861-870 10.1016/S0893-6080(00)00059-9 11156197
31. Seitz RJ Knorr U Azari NP Weder B Cerebral networks in sensorimotor distrubances Brain Res Bull 2001, 54:299-305 10.1016/ S0361-9230(00)00438-X 11287134
32. Oldfield RC The assessment and analysis of handedness: The Edinburgh inventory Neuropsychologia 1971, 9:97-113 10.1016/0028-3932(71)90067-4 5146491
33. Bagby RM Parker JDA Taylor GJ The Twenty-Item Toronto Alexithymia Scale-I. Item selection and cross-validation of the factor structure J Psychosomat Res 1994, 38:23-32 10.1016/0022-3999(94)90005-1
34. Bagby RM Taylor GJ Parker JDA The Twenty-Item Toronto Alexithymia Scale-II. Convergent, Discriminant, and Concurrent Validity J Psychosomat Res 1994, 38:33-40 10.1016/0022-3999(94)90006-X
35. Franz M Popp K Schaefer R Sitte W Schneider C Hardt J Decker O Braehler E Alexithymia in the German general population Soc Psychiatry Psych Epidemiol 2008, 43:54-62 10.1007/s00127-007-0265-1
36. Hautzinger M Bailer M Worall H Keller F BDI. Beck-Depressions-Inventar Huber Bern Göttingen Toronto Seattle 1995
37. Behr M Becker M SEE. Skalen zum Erleben von Emotionen Manual Göttingen: Hogrefe 2004
38. Ekman P Friesen WV Pictures of Facial Affect [slides] Palo Alto, CA: Consulting Psychologists Press 1996
39. Esslen M Pascual-Marqui RD Hell D Kochi K Lehmann D Brain areas and time course of emotional processing Neuroimage 2004, 21:1189-203 10.1016/ j.neuroimage.2003.10.001 15050547
40. Franz M Schaefer R Schneider C Sitte W Bachor J Visual event-related potentials in subjects with alexithymia: Modified processing of emotional aversive information Am J Psychiat 2004, 161:728-735 10.1176/ appi.ajp.161.4.728 15056520
41. Kleiser R Wittsack H-J Bütefisch CM Jörgens S Seitz RJ Functional activation within the PI-DWI mismatch region in recovery from hemiparetic stroke: Preliminary observations Neuroimage 2005, 24:515-523 10.1016/j.neuroimage.2004.08.043 15627593
42. Jackson J A User's Guide to Principal Components John Wiley & Sons: New York 1991
43. Talairach J Tournoux P Co-planar stereotaxic atlas of the human brain New York: Thieme 1998
44. Brett M The MNI brain and the Talairach atlas 14-2-2002. Ref Type: Internet Communication
45. Gauthier The fusiform 'face area' is part of a network that processes faces at the individual level J Cogn Neurosci 2000, 12:495-504 10.1162/ 089892900562165 10931774
46. George N Dolan RJ Fink GR Baylis GC Russell C Driver J Contrast polarity and face recognition in the human fusiform gyrus Nat Neuroscience 1999, 2:574-580 10.1038/9230
47. Hadjikhani N Gelder B Neural basis of prosopagnosia Human Brain Mapp 2002, 16:176-182 10.1002/hbm.10043
48. Halgren E Dale AM Sereno MI Tootell R Marinkovic K Rosen BR Location of human face-selective cortex with respect to retinotopic areas Human Brain Mapp 1999, 7:29-37 10.1002/ (SICI)1097-0193(1999)7:1<29::AID-HBM3>3.0.CO;2-R
49. Ishai A Ungerleider LG Haxby JV Distributed neural systems for the generation of visual images Neuron 2000, 28:979-990 10.1016/ S0896-6273(00)00168-9 11163281
50. Kanwisher N McDermott J Chun MM The fusiform face area: A module in human extrastriate cortex specialized for face perception J Neurosci 1997, 17:4302-4311 9151747
51. Lerner Y Hendler T Ben-Bashat D Harel M Malach R A hierarchical axis of object processing stages in the human visual cortex Cereb Cortex 2001, 11:287-297 10.1093/cercor/11.4.287 11278192
52. Nakamura K Kawashima R Sato N Nakamura Sugiura M Kato T Hatano K Ito K Fukuda H Schormann T Zilles K Functional delineation of the human occipitoltemporal areas related to face and scene processing; a PET study Brain 2000, 123:1903-1912 10.1093/brain/123.9.1903 10960054
53. Narumoto J Okada T Sadato N Fukui K Yonekura Y Attention to emotion modulates fMRI activity in human right superior temporal sulcus Cogn Brain Res 2001, 12(2):225-231 10.1016/S0926-6410(01)00053-2
54. Onitsuka T Shenton ME Kasai K Nestor PG Toner SK Kikinis R Jolesz FA Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia Arch Gen Psychiatry 2003, 60(4):349-355 10.1001/ archpsyc.60.4.349 12695311
55. Pizzagalli DA Lehmann D Hendrick AM Regard M Pascual-Marqui RD Davidson RJ Affective judgments of faces modulate early activity (∼160 ms) within the fusiform gyri Neuroimage 2002, 16:663-677 10.1006/ nimg.2002.1126 12169251
56. Puce A Allison T Asgari M Gore JC McCarthy G Differential sensitivity of human visual cortex to faces, letterstrings, and textures: A functional magnetic resonance imaging study J Neurosci 1996, 16:5205-5215 8756449
57. Rossion B Caldara R Seghier M Schuller A-M Lazeyras F Mayer E A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processing Brain 2003, 126:2381-2395 10.1093/brain/awg241 12876150
58. Rotshtein P Henson RNA Treves A Driver J Dolan RJ Morphing Marilyn into Maggie dissociates physical and identity face representations in the brain Nat Neuroscience 2005, 8:107-113 10.1038/nn1370
59. Schiltz C Sorger B Caldara R Ahmed F Mayer E Goebel R Rossion B Impaired face discrimination in acquired prosopagnosia is associated with abnormal response to individual faces in the right middle fusiform gyrus Cereb Cortex 2006, 16(4):574-586 10.1093/cercor/bhj005 16033923
60. Sergent J Ohta S MacDonald B Functional neuroanatomy of face and object processing Brain 1992, 115:15- 36 10.1093/brain/115.1.15 1559150
61. Steeves JK Culham JC Duchaine BC Pratesi CC Valyear KF Schindler I Humphrey GK Milner AD Goodale MA The fusiform face area is not sufficient for face recognition: Evidence from a patient with dense prosopagnosia and no occipital face area Neuropsychologia 2006, 44:594-609 10.1016/j.neuropsychologia.2005.06.013 16125741
62. Yovel G Kanwisher N The neural basis of the behavioral face-inversion effect Curr Biol 2005, 15:2256-2262 10.1016/j.cub.2005.10.072 16360687
63. Allison T Giner H McCarthy G Nore AC Puce A Luby M Spencer DD Face recognition in human extrastriate cortex J Neurophysiol 1994, 71:821-825 8176446
64. Winston JS Henson RNA Fine-Goulden MR Dolan RJ fMRI-adaptation reveals dissociable neural representations of identity and expression in face perception J Neurophysiol 2004, 92:1830-1839 10.1152/jn.00155.2004 15115795
65. Takamura M Prosopagnosia: A look at the laterality and specificity issues using evidence from neuropsychology and neurophysiology The Harvard Brain 1996 Spring 9-13
66. Ramnani N Owen AM Anterior prefrontal cortex: Insights into function from anatomy and neuroimaging Nat Rev Neurosci 2004, 3:184-194 10.1038/ nrn1343
67. Sugiura M Friston KJ Willmes K Shah NJ Zilles K Fink GR Analysis of intersubject variability in activation: An application to the incidental episodic retrieval during recognition test Human Brain Mapp 2007, 28:49-58 10.1002/hbm.20256
68. Azari NP Missimer J Seitz RJ Religious experience and emotion: Evidence for distinctive neural patterns Int J Psychol Religion 2005, 15:263-281 10.1207/s15327582ijpr1504_1
69. Mobbs D Garrett AS Menon V Rose FE Bellugi U Reiss AL Anomalous brain activation during face and gaze processing in Williams syndrome Neurology 2004, 62:2070-2076 15184616
70. Luks TL Simpson GV Preparatory deployment of attention to motion activates higher-order motion-processing brain regions Neuroimage 2004, 22:1515-1522 10.1016/j.neuroimage.2004.04.008 15275908
71. Gilbert SJ Spengler S Simons JS Steele JD Lawrie SM Frith CD Burgess PW Functional specialization within rostral prefrontal cortex (area 10): A meta-analysis J Cogn Neurosci 2006, 18:932-948 10.1162/ jocn.2006.18.6.932 16839301
72. Kanwisher N Tong F Nakayama K The effect of face inversion on the human fusiform face area Cognition 1998, 68:1-11 10.1016/S0010-0277(98)00035-3 9775516
73. Dolan RJ Fletcher P Morris J Kapur N Deakin JF Frith CD Neural activation during covert processing of positive emotional facial expressions Neuroimage 1996, 4:194-200 10.1006/nimg.1996.0070 9345509
74. Hoffman EA Haxby JV Distinct representations of eye gaze and identity in the distributed human neural system for face perception Nat Neurosci 2000, 3:80-84 10.1038/71152 10607399
75. Pessoa L McKenna E Gutierrez E Ungerleider LG Neural processing of emotional faces requires attention Proc Natl Acad Sci 2002, 99:11458-11463 123278 12177449 10.1073/pnas.172403899
76. Nakamura K Kawashima R Ito K Sugiura M Kato T Nakamura A Hatano K Nagumo S Kubota K Fukuda H Kojima S Activation of the right inferior frontal cortex during assessment of facial emotion J Neurophysiol 1999, 82:1610-1614 10482774
77. Powell EW Leman RB Connections of the nucelus accumbens Brain Res 1976, 105:389-403 10.1016/0006-8993(76)90589-8 816427
78. Roberts AC Tomic DL Parkinson CH Roeling TA Cutter D Robbins TW Everitt BJ Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): An anterograde and retrograde tract-tracing study J Comp Neurol 2007, 502:86-112 10.1002/cne.21300 17335041
79. Tekin S Cummings JL Frontal-subcortical neuronal circuits and clinical neuropsychiatry: An update J Psychosomat Res 2002, 53:647-654 10.1016/ S0022-3999(02)00428-2
80. Siffert J Allen JC Late effects of therapy of thalamic and hypothalamic tumors in childhood: Vascular, neurobehavioral and neoplastic Pediatr Neurosurg 2000, 33:105-111 10.1159/000028985 11070438
81. Corbetta M Kincade JM Ollinger JM McAvoy MP Shulman GL Voluntary orienting is dissociated from target detection in human posterior parietal cortex Neuroscience 2000, 3:292-297 10700263
82. Corbetta M Shulman GL Human cortical mechanisms of visual attention during orienting and search Phil Trans R Soc Lond 1998, 353:1353-1362 10.1098/rstb.1998.0289
83. Hariri AR Bookheimer SY Mazziotta JC Modulatory emotional responses: effect of a neurocortical network on the limbic system Neuroreport 2000, 11:43-48 10.1097/00001756-200001170-00009 10683827
84. Tamm L Menon V Reiss A Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: Event-related fMRI evidence Am J Psych 2006, 163:1033-1043 10.1176/appi.ajp.163.6.1033
85. Garavan H Ross TJ Stein EA Right hemispheric dominance of inhibitory control: An event-related functional MRI study Proc Natl Acad Sci USA 1999, 96:8301-8306 22229 10393989 10.1073/pnas.96.14.8301
86. Decety J Chaminade T Grezes J Meltzoff AN A PET exploration of the neural mechanisms involved in reciprocal imitation Neuroimage 2001, 15:265-272 10.1006/nimg.2001.0938
87. Frith U Frith CD Development and neurophysiology of mentalizing Phil Trans R Soc Lond 2003, 358:459-473 10.1098/rstb.2002.1218
88. Farrer C Franck N Georgieff N Frith CD Decety J Jeannerod M Modulating the experience of agency: A positron emission tomography study Neuroimage 2003, 18:324-333 10.1016/S1053-8119(02)00041-1 12595186
89. Völlm BA Taylor AN Richardson P Corcoran R Stirling J McKie S Deakin JF Elliot R Neuronal correlates of theory of mind and empathy: A functional magnetic resonance imaging study in a nonverbal task Neuroimage 2005, 29:90-98 16122944
90. Blanke O Mohr C Michel CM Pascual-Leone A Brugger P Seeck M Landis T Thut G Linking out-of-body experience and self processing to mental own-body-imagery at the temporoparietal junction J Neurosci 2005, 25:550-557 10.1523/JNEUROSCI.2612-04.2005 15659590
91. Karnath H Himmelbach M Rorden C The subcortical anatomy of human spatial neglect: Putamen, caudate nucleus and pulvinar Brain 2002, 125:350-360 10.1093/brain/awf032 11844735
92. Hedden T Gabrieli JDE The ebb and flow of attention in the human brain Nat Neurosci 2006, 9:863-865 10.1038/nn0706-863 16801917
93. Saxe R Kanwisher N People thinking about thinking people: The role of the temporo-parietal junction in "theory of mind" Neuroimage 2003, 19:1835-1842 10.1016/S1053-8119(03)00230-1 12948738
94. Carr L Iacoboni M Dubeau M-C Mazziota JC Lenzi GL Neural mechanisms of empathy in humans: A relay from neural systems for imitation to limbic areas Proc Natl Acad Sci USA 2003, 100:5497-5592 154373 12682281 10.1073/ pnas.0935845100
95. Singer T Seymour B O'Doherty J Kaube H Dolan RJ Frith CD Empathy for pain involves the affective but not sensory components of pain Science 2004, 303(5661):1157-1162 10.1126/science.1093535 14976305
96. Haxby JV Hoffman EA Gobbini MI The distributed human neural system for face perception TICS 2000, 4:223-233
97. Schweinsburg AD Paulus MP Barlett VC Killeen LA Caldwell LC Pulido C Brown SA Tapert SR An fMRI study of response inhibition in youths with a family history of alcoholism Ann NY Acad Sci 2004, 1021:391-394 10.1196/ annals.1308.050 15251915
98. Iidaka T Matsumoto A Nogawa J Yamamoto Y Sadato N Frontoparietal network involved in successful retrieval from episodic memory. Spatial and temporal analyses using fMRI and ERP Cereb Cortex 2006, 16:1349-1360 10.1093/cercor/bhl040 16861334
99. McIntosh AR Rajah MN Lobaugh N Interactions of prefrontal cortex in relation to awareness in sensory learning Science 1999, 284:1531-1533 10.1126/science.284.5419.1531 10348741
100. Adleman NE Menon V Blasey CM White CD Warsofsky IS Glover GH Reiss AL A developmental fMRI study of the stroop color-word task Neuroimage 2002, 16:61-75 10.1006/nimg.2001.1046 11969318
101. Lane RD Rieman EM Axelrod B Yun LS Holmes A Schwartz GE Neural correlates of levels of emotional awareness. Evidence of an interaction between emotion and attention in the anterior cingulate cortex J Cogn Neurosci 1998, 10:525-535 10.1162/089892998562924 9712681
102. Schäfer R Popp K Jörgens S Lindenberg R Franz M Seitz RJ Alexithymia-like disorder in right anterior cingulate infarction Neurocase 2007, 13:201-208 10.1080/13554790701494964 17786780
103. Fu CHY Williams SCR Brammer MJ Suckling J Kim J Cleare AJ Walsh ND Mitterschiffthaler MT Andrew CM Pich EM Bullmore ET Neural resonses to happy facial expressions in major depression following antidepressant treatment Am J Psych 2006, 164:599-607 10.1176/appi.ajp.164.4.599
104. Servos P Osu R Santi A Kawato M The neural substrates of biological motion perception: An fMRI study Cereb Cortex 2002, 12:772-782 10.1093/ cercor/12.7.772 12050089
105. Barch DM Braver TS Akbudak E Conturo' T Ollinger J Snyder A Anterior cingulate cortex and response conflict: Effects of response modality and processing domain Cereb Cortex 2001, 11:837-848 10.1093/cercor/11.9.837 11532889
106. Bush G Luu P Posner MI Cognitive and emotional influences in anterior cingulate cortex Trends Cogn Sci 2000, 4(6):215-222 10.1016/ S1364-6613(00)01483-2 10827444
107. Fichtenholtz HM Dean HL Dillon DG Yamasaki H McCarthy G LaBar KS Emotion-attention network interactions during a visual oddball task Cogn Brain Res 2004, 20:67-80 10.1016/j.cogbrainres.2004.01.006