TLR4 signaling induces B7-H1 expression through MAPK pathways in bladder cancer cells

Cancer Investigation

Volumn 26, Issue 8, 2008, Pages 816-821

  Qian, Yigang ^a   Deng, Junfang ^a   Geng, Lei ^a   Xie, Haiyang ^a   Jiang, Guoping ^a   Zhou, Lin ^a   Wang, Yan ^a   Yin, Shenyong ^a   Feng, Xiaowen ^a   Liu, Junwei ^a   Ye, Zhou ^a   Zheng, Shusen ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

B7 H1; Bladder cancer; MAPK; TLR4

Indexed keywords

CD14 ANTIGEN; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN B7 H1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CANCER; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTHRACENES; ANTIGENS, CD; ANTIGENS, CD14; CARCINOMA, TRANSITIONAL CELL; CELL LINE, TUMOR; CHROMONES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; TOLL-LIKE RECEPTOR 4; UP-REGULATION; URINARY BLADDER NEOPLASMS;

EID: 53949109360     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900801941852     Document Type: Article

References (25)

1. Pow-Sang, J.M.; Seigne, J.D. Contemporary management of superficial bladder cancer. Cancer Control 2000, 7, 335-339.
2. Oosterlinck, W.; Lobel, B.; Jakse, G.; Malmström, P.U.; Stöckle, M.; Sternberg, C. European Association of Urology (EAU) Working Group on Oncological Urology. Guidelines on Bladder Cancer 2002, 41, 105-112.
3. Tolley, D.A.; Parmar, M.K.; Grigor, K.M.; Lallemand, G.; Benyon, L.L.; Fellows, J.; et al. The effect of intravesical mitomycin C on recurrence of newly diagnosed superficial bladder cancer: a further report with 7 years of follow up. J Urol 1996, 155(4), 1233-1238.
4. Huang, B.; Zhao, J.; Li, H.; He, K.L.; Chen, Y.; Chen, S.H.; et al. Toll-Like Receptors on Tumor Cells Facilitate Evasion of Immune Surveillance. Cancer Res 2005, 65(12), 5009-5014.
5. Dong, H.; Zhu, G.; Tamada, K.; Chen, L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med 1999, 5(12), 1365-1369.
6. Dong, H.; Strome, S.E.; Salomao, D.R.; Tamura, H.; Hirano, F.; Flies, D.B.; et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med 2002, 8(8), 793-800.
7. Brown, J.A.; Dorfman, D.M.; Ma, F.R.; Sullivan, E.L.; Munoz, O.; Wood, C.R.; et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J Immunol 2003, 170(3), 1257-1266.
8. Iwai, Y.; shida, M.; Tanaka, Y.; Okazaki, T.; Honjo, T.; Minato, N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci USA 2002, 99(19), 12293-12297.
9. Wintterle, S.; Schreiner, B.; Mitsdoerffer, M.; Schneider, D.; Chen, L.; Meyermann, R.; et al. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res 2003, 63(21), 7462-7467.
10. Blank, C.; Brown, I.; Peterson, A.C.; Spiotto, M.; Iwai, Y.; Honjo, T.; et al. PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells. Cancer Res 2004, 64(3), 1140-1145.
11. Lamm, D.L. Long-term results of intravesical therapy for superficial bladder cancer. Urol Clin North Am 1992, 19(3), 573-580.
12. Liu, M.K.; Herrera-Velit, P.; Brownsey, R.W.; Reiner, N.E. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 1994, 153(6), 2642-2652.
13. Swantek, J.L.; Cobb, M.H.; Geppert, T.D. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor a (TNF-a) translation: glucocorticoids inhibit TNF-a translation by blocking JNK/SAPK. Mol Cell Biol 1997, 17(11), 6274-6282.
14. Hambleton, J.; Weinstein, S.L.; Lem, L.; DeFranco, A.L. Activation of c-Jun N-terminal kinase in bacterial lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA 1996, 93(7), 2774-2778.
15. Rao, K.M. MAP kinase activation in macrophages. J Leukoc Biol 2001, 69(1), 3-10.
16. Guha, M,; Mackman, N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002, 277(35), 32124-32132.
17. Fukao, T.; Koyasu, S. PI3K and negative regulation of TLR signaling. Trends Immunol 2003, 24(7), 358-63.
18. Loke, P.; Allison, J.P. PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc Natl Acad Sci USA 2003, 100(9), 5336-5341.
19. Lee, S.J.; Jang, B.C.; Lee, S.W.; Yang, Y.I.; Suh, S.I.; Park, Y.M.; et al. Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274). FEBS Lett 2006, 580(3), 755-762.
20. Wintterle, S.; Schreiner, B.; Mitsdoerffer, M.; Schneider, D.; Chen, L.; Meyermann, R.; et al. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res 2003, 63(21), 7462-7467.
21. Ohigashi, Y.; Sho, M.; Yamada, Y.; Tsurui, Y.; Hamada, K.; Ikeda, N.; et al. Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer. Clin Cancer Res 2005, 11(8), 2947-2953.
22. Curiel, T.J.; Wei, S.; Dong, H.; Alvarez, X.; Cheng, P.; Mottram, P.; et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med 2003, 9(5), 562-567.
23. Vabulas, R.M.; Wagner, H.; Schild, H. Heat shock proteins as ligands of toll-like receptors. Curr Top Microbiol Immunol 2002, 270, 169-184.
24. Hirano, F.; Kaneko, K.; Tamura, H.; Dong, H.; Wang, S.; Ichikawa, M.; et al. Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immun. Cancer Res 2005, 65(3), 1089-1096.
25. Curiel, T.J.; Wei, S.; Dong, H.; Alvarez, X.; Cheng, P.; Mottram, P.; et al. Blockade of B7-H1 improvesmyeloid dendritic cell-mediated antitumor immunity. Nat Med 2003, 9(5), 562-567.