Synthesis of substituted imidazo[1,2-h][1,7]naphthyridines as H +/K+-ATPase inhibiting drug precursors via directed ortho-metalation of imidazo[1,2-a]pyridines

Synthesis

Volumn , Issue 19, 2008, Pages 3065-3070

  Senn Bilfinger, Jörg ^a   Kohl, Bernhard ^a   Rainer, Georg ^a   Buhr, Wilm ^a   Holst, Hans Christof ^a   Zimmermann, Peter Jan ^a  

^a Nycomed GmbH   (Germany)

Author keywords

Cyclizations; Directed ortho metalation; H+ K+ ATPase; Lithiation; Stille reaction

Indexed keywords

ACIDS; AMIDES; CHEMICAL REACTIONS; LITHIUM; PALLADIUM;

CYCLIZATIONS; DIRECTED ORTHO-METALATION; H+/K+-ATPASE; LITHIATION; STILLE REACTION;

PYRIDINE;

2,3 DIMETHYL 9 PHENYL 9,10 DIHYDROIMIDAZO[1,2 H][1,7]NAPHTHYRIDIN 7(8H) ONE; ENZYME INHIBITOR; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; IMIDAZO[1,2 H][1,7]PYRIDINE; IMIDAZOPYRIDINE DERIVATIVE; PALLADIUM; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CYCLIZATION; DIRECTED ORTHO METALATION; ENZYME INHIBITION; PROTON NUCLEAR MAGNETIC RESONANCE; STILLE REACTION; SYNTHESIS;

EID: 53949091031     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1067264     Document Type: Article

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