Glucuronide conjugates of Soraprazan (BY359), a new potassium-competitive acid blocker (P-CAB) for the treatment of acid-related diseases

Tetrahedron Letters

Volumn 47, Issue 19, 2006, Pages 3321-3323

  Senn Bilfinger, Jörg ^a   Ferguson, John R ^b   Holmes, Michael A ^b   Lumbard, Keith W ^b   Huber, Reinhard ^a   Zech, Karl ^a   Hummel, Rolf Peter ^a   Zimmermann, Peter J ^a  

^a ALTANA PHARMA AG   (Germany)

^b Sigma Aldrich Co   (United States)

Author keywords

Anti ulcer; Gastric anti secretory; Glucuronidation; Imidazo naphthyridine; Soraprazan

Indexed keywords

ACETIC ACID DERIVATIVE; AGLYCONE; ESTER; GLUCURONIDE; HYDRAZINE; LEWIS ACID; SORAPRAZAN; STOMACH SECRETION INHIBITOR; SULFONIC ACID DERIVATIVE; TRIFLUOROMETHANESULFONIC ACID TRIMETHYLSILYL ESTER; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; DEPROTECTION REACTION; GLUCURONIDATION; HYDROLYSIS; KOENIGS KNORR REACTION; METHODOLOGY; PEPTIC ULCER; PHOTOREACTIVITY; STOMACH ACID SECRETION; STOMACH ULCER;

EID: 33646526736     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.02.156     Document Type: Article

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11. 3), 55.70 (C-9), 57.86 (C-20), 66.42 (C-18), 70.76 (C-19), 71.39 (C-24), 72.95 (C-22), 74.84 (C-7), 75.41 (C-8), 75.55 (C-25), 76.19 (C-23), 102.59 (C-21), 105.17 (C-6a), 110.84 (C-5), 115.50 (C-6), 116.71 (C-3), 126.04 (C-15), 126.55 (C-13, C-17), 127.42 (C-14, C-16), 131.58 (C-10a), 135.08 (C-11), 135.60 (C-2), 141.10 (C-12), 170.35 (COOH).