Sexually dimorphic distribution of sst2A receptors on growth hormone-releasing hormone neurones in mice: Modulation by gonadal steroids

Journal of Neuroendocrinology

Volumn 20, Issue 11, 2008, Pages 1278-1287

  Bouyer, K ^a   Faivre Bauman, A ^a,b   Robinson, I C A F ^c   Epelbaum, Jacques ^a,b,d   Loudes, C ^a,b  

^a CENTRE DE PSYCHIATRIE ET NEUROSCIENCES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

GHRH; Mouse; Sexual dimorphism; Somatostatin; sst2A

Indexed keywords

ESTRADIOL; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; PROLACTIN RECEPTOR; SEX HORMONE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR 2; SOMATOSTATIN RECEPTOR 2A; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; GONADECTOMY; HORMONE DETERMINATION; HORMONE RELEASE; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE;

ANIMALS; ESTRADIOL; FEMALE; GROWTH HORMONE-RELEASING HORMONE; HYPOTHALAMUS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; ORCHIECTOMY; OVARIECTOMY; RECEPTORS, SOMATOSTATIN; SEX CHARACTERISTICS; TESTOSTERONE;

EID: 53949086079     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2008.01780.x     Document Type: Article

References (47)

1. Plotsky PM, Vale W. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 1985; 230: 461-463.
2. Miki N, Ono M, Shizume K. Withdrawal of endogenous somatostatin induces secretion of growth hormone-releasing factor in rats. J Endocrinol 1988; 117: 245-252.
3. Zheng H, Bailey A, Jiang MH, Honda K, Chen HY, Trumbauer ME, Van der Ploeg LH, Schaeffer JM, Leng G, Smith RG. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol 1997; 11: 1709-1717.
4. Gatford KL, Egan AR, Clarke IJ, Owens PC. Sexual dimorphism of the somatotrophic axis. J Endocrinol 1998; 157: 373-389.
5. Carlsson LM, Clark RG, Robinson IC. Sex difference in growth hormone feedback in the rat. J Endocrinol 1990; 126: 27-35.
6. Chowen-Breed JA, Steiner RA, Clifton DK. Sexual dimorphism and testosterone-dependent regulation of somatostatin gene expression in the periventricular nucleus of the rat brain. Endocrinology 1989; 125: 357-362.
7. Murray HE, Simonian SX, Herbison AE, Gillies GE. Correlation of hypothalamic somatostatin mRNA expression and peptide content with secretion: Sexual dimorphism and differential regulation by gonadal factors. J Neuroendocrinol 1999; 11: 27-33.
8. Zhang WH, Beaudet A, Tannenbaum GS. Sexually dimorphic expression of sst1 and sst2 somatostatin receptor subtypes in the arcuate nucleus and anterior pituitary of adult rats. J Neuroendocrinol 1999; 11: 129-136.
9. Kimura N, Tomizawa S, Arai KN. Chronic treatment with estrogen up-regulates expression of sst2 messenger ribonucleic acid (mRNA) but down-regulates expression of sst5 mRNA in rat pituitaries. Endocrinology 1998; 139: 1573-1580.
10. Senaris RM, Lago F, Dieguez C. Gonadal regulation of somatostatin receptor 1, 2 and 3 mRNA levels in the rat anterior pituitary. Brain Res Mol Brain Res 1996; 38: 171-175.
11. Painson JC, Thorner MO, Krieg RJ, Tannenbaum GS. Short-term adult exposure to estradiol feminizes the male pattern of spontaneous and growth hormone-releasing factor-stimulated growth hormone secretion in the rat. Endocrinology 1992; 130: 511-519.
12. Painson JC, Veldhuis JD, Tannenbaum GS. Single exposure to testosterone in adulthood rapidly induces regularity in the growth hormone release process. Am J Physiol Endocrinol Metab 2000; 278: E933-E940.
13. Low MJ, Otero-Corchon V, Parlow AF, Ramirez JL, Kumar U, Patel YC, Rubinstein M. Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest 2001; 107: 1571-1580.
14. Luque RM, Kineman RD. Gender-dependent role of endogenous somatostatin in regulating growth hormone-axis function in mice. Endocrinology 2007; 148: 5998-6006.
15. Bouyer K, Loudes C, Robinson IC, Epelbaum J, Faivre-Bauman A. Sexually dimorphic distribution of sst2A somatostatin receptors on growth hormone-releasing hormone neurons in mice. Endocrinology 2006; 147: 2670-2674.
16. Becker JB, Arnold AP, Berkley KJ, Blaustein JD, Eckel LA, Hampson E, Herman JP, Marts S, Sadee W, Steiner M, Taylor J, Young E. Strategies and methods for research on sex differences in brain and behavior. Endocrinology 2005; 146: 1650-1673.
17. Balthasar N, Mery PF, Magoulas CB, Mathers KE, Martin A, Mollard P, Robinson IC. Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: A ventral hypothalamic network. Endocrinology 2003; 144: 2728-2740.
18. Helboe L, Moller M, Norregaard L, Schiodt M, Stidsen CE. Development of selective antibodies against the human somatostatin receptor subtypes sst1-sst5. Brain Res Mol Brain Res 1997; 49: 82-88.
19. Csaba Z, Bernard V, Helboe L, Bluet-Pajot MT, Bloch B, Epelbaum J, Dournaud P. In vivo internalization of the somatostatin sst2A receptor in rat brain: Evidence for translocation of cell-surface receptors into the endosomal recycling pathway. Mol Cell Neurosci 2001; 17: 646-661.
20. Loudes C, Petit F, Kordon C, Faivre-Bauman A. Distinct populations of hypothalamic dopaminergic neurons exhibit differential responses to brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT3). Eur J Neurosci 1999; 11: 617-624.
21. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.
22. Wersinger SR, Haisenleder DJ, Lubahn DB, Rissman EF. Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha. Endocrinology 1999; 11: 137-143.
23. Mode A, Gustafsson JA. Sex and the liver-a journey through five decades. Drug Metab Rev 2006; 38: 197-207.
24. Norstedt G, Palmiter R. Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver. Cell 1984; 36: 805-812.
25. Clark RG, Robinson IC. Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats. Endocrinology 1988; 122: 2675-2682.
26. Painson JC, Tannenbaum GS. Sexual dimorphism of somatostatin and growth hormone-releasing factor signaling in the control of pulsatile growth hormone secretion in the rat. Endocrinology 1991; 128: 2858-2866.
27. Bertherat J, Dournaud P, Berod A, Normand E, Bloch B, Rostene W, Kordon C, Epelbaum J. Growth hormone-releasing hormone-synthesizing neurons are a subpopulation of somatostatin receptor-labelled cells in the rat arcuate nucleus: A combined in situ hybridization and receptor light-microscopic radioautographic study. Neuroendocrinology 1992; 56: 25-31.
28. Chowen JA, Frago LM, Argente J. The regulation of GH secretion by sex steroids. Eur J Endocrinol 2004; 151 (Suppl 3): U95-U100.
29. MacLeod JN, Pampori NA, Shapiro BH. Sex differences in the ultradian pattern of plasma growth hormone concentrations in mice. J Endocrinol 1991; 131: 395-399.
30. Nurhidayat T, Sukamoto Y, Sasaki F. Role of the gonads in sex differentiation of growth hormone-releasing hormone and somatostatin neurons in the mouse hypothalamus during postnatal development. Brain Res 2001; 890: 154-161.
31. Kuwahara S, Kesuma Sari D, Tsukamoto Y, Tanaka S, Sasaki F. Age-related changes in growth hormone (GH)-releasing hormone and somatostatin neurons in the hypothalamus and in GH cells in the anterior pituitary of female mice. Brain Res 2004; 1025: 113-122.
32. Slama A, Videau C, Kordon C, Epelbaum J. Estradiol regulation of somatostatin receptors in the arcuate nucleus of the female rat. Neuroendocrinology 1992; 56: 240-245.
33. Olias G, Viollet C, Kusserow H, Epelbaum J, Meyerhof W. Regulation and function of somatostatin receptors. J Neurochem 2004; 89: 1057-1091.
34. Sarret P, Botto JM, Vincent JP, Mazella J, Beaudet A. Preferential expression of sst2A over sst2B somatostatin receptor splice variant in rat brain and pituitary. Neuroendocrinology 1998; 68: 37-43.
35. Tamura H, Sugihara H, Kamegai J, Minami S, Wakabayashi I. Masculinizing effect of dihydrotestosterone on growth hormone secretion is inhibited in ovariectomized rats with anterolateral deafferentation of the medial basal hypothalamus or in intact female rats. J Neuroendocrinol 2000; 12: 369-375.
36. Herbison AE, Theodosis DT. Absence of estrogen receptor immunoreactivity in somatostatin (SRIF) neurons of the periventricular nucleus but sexually dimorphic colocalization of estrogen receptor and SRIF immunoreactivities in neurons of the bed nucleus of the stria terminalis. Endocrinology 1993; 132: 1707-1714.
37. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Estrogen receptor (ER)alpha, but not ERbeta, gene is expressed in growth hormone-releasing hormone neurons of the male rat hypothalamus. Endocrinology 2001; 142: 538-543.
38. Shimizu T, Kamegai J, Tamura H, Ishii S, Sugihara H, Oikawa S. The estrogen receptor (ER) alpha, but not ER beta, gene is expressed in hypothalamic growth hormone-releasing hormone neurons of the adult female rat. Neurosci Res 2005; 52: 121-125.
39. Gevers E, Pincus SM, Robinson IC, Veldhuis JD. Differential orderliness of the GH release process in castrate male and female rats. Am J Physiol 1998; 274: R437-R444.
40. Ahluwalia A, Clodfelter KH, Waxman DJ. Sexual dimorphism of rat liver gene expression: Regulatory role of growth hormone revealed by deoxyribonucleic acid microarray analysis. Mol Endocrinol 2004; 18: 747-760.
41. Zeitler P, Tannenbaum GS, Clifton DK, Steiner RA. Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats. Proc Natl Acad Sci USA 1991; 88: 8920-8924.
42. Maiter D, Koenig JI, Kaplan LM. Sexually dimorphic expression of the growth hormone-releasing hormone gene is not mediated by circulating gonadal hormones in the adult rat. Endocrinology 1991; 128: 1709-1716.
43. Bennett PA, Levy A, Carmignac DF, Robinson IC, Lightman SL. Differential regulation of the growth hormone receptor gene: Effects of dexamethasone and estradiol. Endocrinology 1996; 137: 3891-3896.
44. Fodor M, Oudejans CB, Delemarre-van de Waal HA. Absence of androgen receptor in the growth hormone releasing hormone-containing neurones in the rat mediobasal hypothalamus. J Neuroendocrinol 2001; 13: 724-727.
45. Herbison AE. Sexually dimorphic expression of androgen receptor immunoreactivity by somatostatin neurones in rat hypothalamic periventricular nucleus and bed nucleus of the stria terminalis. J Neuroendocrinol 1995; 7: 543-553.
46. Huang X, Harlan RE. Androgen receptor immunoreactivity in somatostatin neurons of the periventricular nucleus but not in the bed nucleus of the stria terminalis in male rats. Brain Res 1994; 652: 291-296.
47. Csaba Z, Simon A, Helboe L, Epelbaum J, Dournaud P. Targeting sst2A receptor-expressing cells in the rat hypothalamus through in vivo agonist stimulation: Neuroanatomical evidence for a major role of this subtype in mediating somatostatin functions. Endocrinology 2003; 144: 1564-1573.