Differential orderliness of the GH release process in castrate male and female rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 274, Issue 2 43-2, 1998, Pages

  Gevers, Evelien ^a   Pincus, Steve M ^b   Robinson, Iain C A F ^c   Veldhuis, Johannes D ^d  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Natl Institute for Medical Research ^*

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^d UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Entropy; Growth hormone; Pituitary; Rodent; Sex

Indexed keywords

GONADORELIN; GONADORELIN AGONIST; GROWTH HORMONE; SEX HORMONE; SOMATOSTATIN; TRIPTORELIN;

ARTICLE; CASTRATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GROWTH HORMONE RELEASE; MALE; NEGATIVE FEEDBACK; NONHUMAN; ORCHIECTOMY; OVARIECTOMY; PREPUBERTY; PRIORITY JOURNAL; RAT; ANIMAL; PERIODICITY; PHYSIOLOGY; SECRETION; SEXUAL DEVELOPMENT;

ANIMALS; FEMALE; GONADAL STEROID HORMONES; GROWTH HORMONE; MALE; ORCHIECTOMY; OVARIECTOMY; PERIODICITY; RATS; SEX CHARACTERISTICS; TRIPTORELIN;

EID: 0031990840     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1998.274.2.r437     Document Type: Article

References (75)

1. Argente, J., B. J. Chowen, R. A. Steiner, and D. K. Clifton. Somatostatin messenger RNA in hypothalamic neurons is increased by testosterone through activation of androgen receptors and not by aromatization to estradiol. Neuroendocrinology 52: 342-349, 1990.
2. Argente, J., J. A. Chowen, P. Zeitler, D. K. Clifton, and R. A. Steiner. Sexual dimorphism of growth hormone-releasing hormone and somatostatin gene expression in the hypothalamus of the rat during development. Endocrinology 128: 2369-2375, 1991.
3. Barreca, A., P. G. Artini, P. Del Monte, P. Ponzani, P. Pasquni, G. Cariola, A. Volpe, A. R. Genazzani, G. Giordano, and F. Minuto. In vivo and in vitro effect of growth hormone on estradiol secretion by human granulosa cells. J. Clin. Endocrinol. Metab. 77: 61-67, 1993.
4. Boujrad, N., O. Ogwuegbu, M. Garnier, C. H. Lee, B. M. Martin, and V. Papadopoulos. Identification of a stimulator of steroid hormone synthesis isolated from testis. Science 268: 1609-1612, 1995.
5. Carlsson, L., E. Eriksson, H. Seeman, and J. O. Jansson. Oestradiol increases baseline growth hormone levels in the male rat: possible direct action on the pituitary. Acta Physiol. Scand. 129: 393-399, 1987.
6. Carlsson, L. M. S., R. G. Clark, and I. C. A. F. Robinson. Sex difference in growth hormone feedback in the rat. J. Endocrinol. 126: 27-35, 1990.
7. Carmignac, D. F., D. M. Flavell, and I. C. A. F. Robinson. Pituitary growth hormone releasing factor receptor expression in normal and dwarf rats. Neuroendocrinology 64: 177-185, 1996.
8. Chomczynski, P., T. R. Downs, and L. A. Frohman. Feedback regulation of growth hormone releasing hormone gene expression by growth hormone in the rat hypothalamus. Mol. Endocrinol. 2: 236-241, 1988.
9. Chowen, J. A., J. Argente, S. Gonzalez-Parra, and L. M. Garcia Segura. Differential effects of the neonatal and adult sex steroid environments on the organization and activation of hypothalamic growth hormone-releasing hormone and somatostatin neurons. Endocrinology 133: 2792-2802, 1993.
10. Clark, R. G., L. M. S. Carlsson, B. Rafferty, and I. C. A. F. Robinson. The rebound release of growth hormone (GH) following somatostatin infusion in rats involves hypothalamic GH-releasing factor release. J. Endocrinol. 119: 397-404, 1988.
11. Clark, R. G., L. M. S. Carlsson, and I. C. A. F. Robinson. Growth hormone secretory profiles in conscious female rats. J. Endocrinol. 114: 399-407, 1987.
12. Clark, R. G., L. M. S. Carlsson, and I. C. A. F. Robinson. Growth hormone secretory profiles in conscious female rats. J. Endocrinol. 114: 399-407, 1987.
13. Clark, R. G., L. M. S. Carlsson, and I. C. A. F. Robinson. Growth hormone (GH) secretion in the conscious rat: negative feedback of GH on its own release. J. Endocrinol. 119: 201-209, 1988.
14. Clark, R. G., G. Chambers, J. Lewin, and I. C. A. F. Robinson. Automated repetitive microsampling of blood: growth hormone profiles in conscious male rats. Endocrinology 111: 27-35, 1986.
15. Clark, R. G., J. O. Jansson, O. Isaksson, and I. C. Robinson. Intravenous growth hormone: growth responses to patterned infusions in hypophysectomized rats. J. Endocrinol. 104: 53-61, 1985.
16. Clark, R. G., and I. C. Robinson. Paradoxical growth-promoting effects induced by patterned infusions of somatostatin in female rats. Endocrinology 122: 2675-2682, 1988.
17. Clark, R. G., and I. C. A. F. Robinson. Growth hormone responses to multiple injections of a fragment of human growth hormone-releasing factor in conscious male and female rats. J. Endocrinol. 106: 281-289, 1985.
18. Eden, S. Age- and sex-related differences in episodic growth hormone secretion in the rat. Endocrinology 105: 555-560, 1979.
19. Ekberg, S., L. Carlsson, B. Carlsson, H. Billig, and J. O. Jansson. Plasma growth hormone pattern regulates epidermal growth factor (EGF) receptor messenger ribonucleic acid levels and EGF binding in the rat liver. Endocrinology 125: 2158-2166, 1989.
20. Eriksson, L. Growth hormone in human pregnancy. Maternal 24-hour serum profiles and experimental effects of continuous GH secretion. Acta Obstet. Gynecol. Scand. 147: 1-38, 1989.
21. Frohman, L. A., T. R. Downs, I. J. Clarke, and G. B. Thomas. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep: spontaneous secretion and response to insulin-induced hypoglycemia. J. Clin. Invest. 86: 17-24, 1990.
22. Gevers, E. F., J. M. Wit, and I. C. A. F. Robinson. Effects of long-term GnRH-analogue treatment on growth, growth hormone (GH) secretion, GH receptors and GH binding protein in the rat. Pediatr. Res. In press.
23. Hartman, M. L., S. M. Pincus, M. L. Johnson, D. H. Matthews, L. M. Faunt, M. L. Vance, M. O. Thorner, and J. D. Veldhuis. Enhanced basal and disorderly growth hormone (GH) secretion distinguish acromegalic from normal pulsatile GH release. J. Clin. Invest. 94: 1277-1288, 1994.
24. Ho, K. Y., W. S. Evans, R. M. Blizzard, J. D. Veldhuis, G. R. Merriam, E. Samojlik, R. Furlanetto, A. D. Rogol, D. L. Kaiser, and M. O. Thorner. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: importance of endogenous estradiol concentrations. J. Clin. Endocrinol. Metab. 64: 51-58, 1987.
25. Jansson, J.-O., S. Eden, and O. Isaksson. Sexual dimorphism in the control of growth hormone secretion. Endocr. Rev. 6: 128-150, 1985.
26. Jansson, J.-O., S. Ekberg, S. B. Hoath, W. G. Beamer, and L. A. Frohman. Growth hormone enhances hepatic epidermal growth factor receptor concentration in mice. J. Clin. Invest. 82: 1871-1876, 1988.
27. Jansson, J.-O., S. Ekberg, O. Isaksson, A. Mode, and J. A. Gustafsson. Imprinting of growth hormone secretion, body growth, and hepatic steroid metabolism by neonatal testosterone. Endocrinology 117: 1881-1889, 1985.
28. Jansson, J.-O., and L. A. Frohman. Differential effects of neonatal and adult androgen exposure on the growth hormone secretory pattern in male rats. Endocrinology 120: 1551-1557, 1987.
29. Jansson, J.-O., and L. A. Frohman. Inhibitory effect of the ovaries on neonatal androgen imprinting of growth hormone secretion in female rats. Endocrinology 121: 1417-1423, 1987.
30. Katakami, H., A. Arimura, and L. A. Frohman. Growth hormone (GH)-releasing factor stimulates hypothalamic somatostatin release: an inhibitory feedback effect on GH secretion. Endocrinology 118: 1872-1877, 1986.
31. Katakami, H., T. R. Downs, and L. A. Frohman. Inhibitory effect of hypothalamic medial preoptic area somatostatin on growth hormone-releasing factor in the rat. Endocrinology 123: 1103-1109, 1988.
32. Kerrigan, J. R., P. M. Martha, Jr., R. J. Krieg, Jr., A. D. Rogol, and W. S. Evans. Somatostatin inhibition of growth hormone secretion by somatotropes from male, female and androgen receptor-deficient rats: evidence for differing sensitivities. Endocrinology 125: 3078-3083, 1989.
33. Kerrigan, J. R., and A. D. Rogol. The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr. Rev. 13: 281-298, 1992.
34. Korytko, A., P. Zeitler, and L. Cutler. Developmental regulation of pituitary GRF-receptor gene expression in the rat. Endocrinology 137: 1326-1331, 1996.
35. Lanzi, R., and G. S. Tannenbaum. Time course and mechanism of growth hormone's negative feedback effect on its own spontaneous release. Endocrinology 130: 780-788, 1992.
36. Maiter, D., J. I. Koenig, and L. M. Kaplan. Sexually dimorphic expression of the growth hormone-releasing hormone gene is not mediated by circulating gonadal hormones in the adult rat. Endocrinology 128: 1709-1716, 1991.
37. Mayo, K. E. Molecular cloning and expression of a pituitary-specific receptor for growth hormone releasing hormone. Mol. Endocrinol. 6: 1734-1744, 1992.
38. Painson, J. C., and G. S. Tannenbaum. Sexual dimorphism of somatostatin and growth hormone-releasing factor signaling in the control of pulsatile growth hormone secretion in the rat. Endocrinology 128: 2858-2866, 1991.
39. Pincus, S. M. Approximate entropy as a measure of system complexity. Proc. Natl. Acad. Sci. USA 88: 2297-2301, 1991.
40. Pincus, S. M. Approximating Markov chains. Proc. Natl. Acad. Sci. USA 89: 4432-4436, 1992.
41. Pincus, S. M. Greater signal regularity may indicate increased system isolation. Math. Biosci. 122: 161-181, 1994.
42. Pincus, S. M. Approximate entropy (ApEn) as a complexity measure. Chaos 5: 110-117, 1995.
43. Pincus, S. M., T. R. Cummins, and G. G. Haddad. Heart rate control in normal and aborted SIDS infants. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R638-R646, 1993.
44. Pincus, S. M., E. Gevers, I. C. A. Robinson, F. Roelfsema, M. L. Hartman, and J. D. Veldhuis. Females secrete growth hormone with more process irregularity than males in both human and rat. Am. J. Physiol. 270 (Endocrinol. Metab. 33): E107-E115, 1996.
45. Pincus, S. M., and A. L. Goldberger. Physiological time-series analysis: what does regularity quantify? Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H1643-H1656, 1994.
46. Pincus, S. M., and W. M. Huang. Approximate entropy: statistical properties and applications. Commun. Stat. Theory Methods 21: 3061-3077, 1992.
47. Pincus, S. M., and R. E. Kalman. Not all (possibly) "random" sequences are created equal. Proc. Natl. Acad. Sci. USA 94: 3513-3518, 1997.
48. Pincus, S. M., and D. L. Keefe. Quantification of hormone pulsatility via an approximate entropy algorithm. Am. J. Physiol. 262 (Endocrinol. Metab. 25): E741-E754, 1992.
49. Pincus, S. M., T. Mulligan, A. Iranmanesh, S. Gheorghiu, M. Godschalk, and J. D. Veldhuis. Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males: dual novel facets. Proc. Natl. Acad. Sci. USA 93: 14100-14105, 1996.
50. Pincus, S. M., and B. H. Singer. Randomness and degrees of irregularity. Proc. Natl. Acad. Sci. USA 93: 2083-2088, 1996.
51. Pincus, S. M., and R. R. Viscarello. Approximate entropy: a regularity measure for fetal heart rate analysis. Obstet. Gynecol. 79: 249-255, 1992.
52. Plotsky, P. M., and W. Vale. Patterns of growth hormone-releasing factor and somatostatin secretion into the hypophysial-portal circulation of the rat. Science 230: 461-465, 1985.
53. Sato, M., and L. A. Frohman. Differential effects of central and peripheral administration of growth hormone (GH) and insulin-like growth factor on hypothalamic GH-releasing hormone and somatostatin gene expression in GH-deficient dwarf rats. Endocrinology 133: 793-799, 1993.
54. Siragy, H. M., W. V. R. Vieweg, S. M. Pincus, and J. D. Veldhuis. Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism. J. Clin. Endocrinol. Metab. 80: 28-33, 1995.
55. Straume, M., L. Chen, M. L. Johnson, and J. D. Veldhuis. Systems-level analysis of physiological regulation interactions controlling complex secretory dynamics of growth hormone axis: a connectionist network model. Methods Neurosci. 28: 270-310, 1995.
56. Sundseth, S. S., J. A. Alberta, and D. J. Waxman. Sex-specific, growth hormone-regulated transcription of the cytochrome p450 2C11 and 2C12 genes. J. Biol. Chem. 267: 3907-3914, 1992.
57. Tannenbaum, G. S. Neuroendocrine control of growth hormone secretion. Acta Paediatr. Scand. Suppl. 372: 5-16, 1991.
58. Tannenbaum, G. S. Multiple levels of cross-talk between somatostatin (SRIF) and growth hormone (GH)-releasing factor in genesis of pulsatile GH secretion. Clin. Pediatr. (Phila.) 3: 97-110, 1994.
59. Tannenbaum, G. S., W. Gurd, M. Lapointe, and M. Pollak. Tamoxifen attenuates pulsatile growth hormone secretion: mediation in part by somatostatin. Endocrinology 130: 3395-3401, 1992.
60. Tannenbaum, G. S., and N. Ling. The interrelationship of growth hormone (GH)-releasing factor and somatostatin in generation of the ultradian rhythm of GH secretion. Endocrinology 115: 1952-1957, 1984.
61. Tannenbaum, G. S., and J. B. Martin. Evidence for an endogenous ultradian rhythm governing growth hormone secretion in the rat. Endocrinology 98: 562-570, 1976.
62. Tannenbaum, G. S., J. C. Painson, A. M. Lengyel, and P. Brazeau. Paradoxical enhancement of pituitary growth hormone (GH) responsiveness to GH-releasing factor in the face of high somatostatin tone. Endocrinology 124: 1380-1388, 1989.
63. Turner, J. P., and G. S. Tannenbaum. In vivo evidence of a positive role for somatostatin to optimize pulsatile growth hormone secretion. Am. J. Physiol. 269 (Endocrinol. Metab. 32): E683-E690, 1995.
64. Van den Berg, G., S. M. Pincus, J. D. Veldhuis, M. Frolich, and F. Roelfsema. Greater disorderliness of adrenocorticotropin and cortisol release accompanies pituitary-dependent Cushing's Disease. Eur. J. Endocrinol. 136: 394-400, 1997.
65. Van den Berg G., J. D. Veldhuis, M. Frolich, and F. Roelfsema. An amplitude-specific divergence in the pulsatile mode of GH secretion underlies the gender difference in mean GH concentrations in men and premenopausal women. J. Clin. Endocrinol. Metab. 81: 2460-2466, 1996.
66. Veldhuis, J. D., A. Y. Liem, S. South, A. Weltman, J. Weltman, D. A. Clemmons, R. Abbott, T. Mulligan, M. L. Johnson, S. M. Pincus, M. Straume, and A. Iranmanesh. Differential impact of age, sex-steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay. J. Clin. Endocrinol. Metab. 80: 3209-3222, 1995.
67. Veldhuis, J. D, D. L. Metzger, P. M. Martha, Jr., N. Mauras, J. R. Kerrigan, B. Keenan, A. D. Rogol, and S. M. Pincus. Estrogen and testosterone, but not a non-aromatizable androgen, direct network integration of the hypothalamo-somatotrope (GH)-IGF-I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J. Clin. Endocrinol. Metab. 82: 3414-3420, 1997.
68. Waxman, D. J., N. A. Pampori, P. A. Ram, A. K. Agrawal, and B. H. Shapiro. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc. Natl. Acad. Sci. USA 88: 6868-6872, 1991.
69. Waxman, D. J., P. A. Ram, S. H. Park, and H. K. Choi. Intermittent plasma growth hormone triggers tyrosine phophorylation and nuclear translocation of a liver-expressed, STAT 5-related DNA binding protein. J. Biol. Chem. 270: 13262-13270, 1995.
70. Wehrenberg, W. B., and A. Giustina. Basic counterpoint: mechanisms and pathways of gonadal steroid modulation of growth hormone secretion. Endocr. Rev. 13: 299-308, 1992.
71. Wells, T., A. Mode, E. Floby, and I. C. Robinson. The sensitivity of hepatic CYP2C gene expression in baseline growth hormone (GH) bioactivity in dwarf rats: effects of GH-binding protein in vivo. Endocrinology 134: 2135-2141, 1994.
72. Werner, H., Y. Koch, F. Baldino, and I. Gozes. Steroid regulation of somatostatin mRNA in the rat hypothalamus. J. Biol. Chem. 263: 7666-7671, 1988.
73. Xu, Y., M. Berelowitz, and J. F. Bruno. Dexamethasone regulates somatostatin receptor subtype messenger ribonucleic acid expression in rat pituitary GH4C1 cells. Endocrinology 136: 5070-5075, 1995.
74. Zeitler, P., J. Argente, J. A. Chowen-Breed, D. K. Clifton, and R. A. Steiner. Growth hormone-releasing hormone messenger ribonucleic acid in the hypothalamus of the adult male rat is increased by testosterone. Endocrinology 127: 1362-1368, 1990.
75. Zeitler, P., G. S. Tannenbaum, D. K. Clifton, and R. A. Steiner. Ultradian oscillations in somatostatin and growth hormone-releasing hormone mRNAs in the brains of adult male rats. Proc. Natl. Acad. Sci. USA 88: 8920-8924, 1991.