Concise asymmetric synthesis of (+)-febrifugine utilizing trans-selective intramolecular conjugate addition

Synthesis

Volumn , Issue 19, 2008, Pages 3081-3087

  Sukemoto, Satoshi ^a   Oshige, Miyo ^a   Sato, Masahiro ^a   Mimura, Ken Ichiro ^a   Nishioka, Hiromi ^a   Abe, Hitoshi ^b   Harayama, Takashi ^c   Takeuchi, Yasuo ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Asymmetric synthesis; Febrifugine; Intramolecular conjugate addition; Lewis acid

Indexed keywords

KETONES; ORGANIC COMPOUNDS;

ASYMMETRIC SYNTHESIS; FEBRIFUGINE; INTRAMOLECULAR CONJUGATE ADDITION; LEWIS ACID;

ACIDS;

ANTIMALARIAL AGENT; ENAMINE; FEBRIFUGINE; KETONE; LEWIS ACID;

ADDITION REACTION; ANTIMALARIAL ACTIVITY; ARTICLE; ASYMMETRIC SYNTHESIS; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ENANTIOSELECTIVITY; INTRAMOLECULAR CONJUGATE ADDITION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 53949085124     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2008-1067271     Document Type: Article

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