Total synthesis of dl-febrifugine and dl-isofebrifugine

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 6, 1999, Pages 905-906

  Takeuchi, Yasuo ^a   Abe, Hitoshi ^a   Harayama, Takashi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Antimalarial activity; Claisen rearrangement; Febrifugine; Stereoselective reduction; Total synthesis

Indexed keywords

ANTIMALARIAL AGENT; FEBRIFUGINE; ISOFEBRIFUGINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG SYNTHESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

EID: 0032975193     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.905     Document Type: Article

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20. 11)) δ: 19.99 (20.1), 26.71 (26.8), 43.24 (43.4), 44.46 (44.6), 49.77 (50.0), 55.62 (55.8), 77.25 (77.0), 105.38 (105.6), 121.82 (122.1), 126.79 (127.1), 127.42 (127.3), 128.26 (127.7), 134.24 (134.6), 147.97 (148.3), 148.14 (148.5), 161.37 (161.8).
21. 11)) δ: 25.83 (25.6), 34.26 (34.5), 43.75 (44.0), 45.62 (46.0), 54.70 (55.0), 60.12 (60.2), 70.76 (72.3), 121.39 (122.1), 126.06 (127.0), 127.18 (127.7), 127.26 (127.8), 134.52 (134.8), 148.00 (146.7), 148.11 (148.5), 159.99 (161.3), 203.90 (203.1).