메뉴 건너뛰기




Volumn 33, Issue 9, 2008, Pages 523-531

Ixabepilone (Ixempra), a therapeutic option for locally advanced or metastatic breast cancer

Author keywords

Anthracyclines; Breast cancer; Capecitabine; Epothilones; Ixabepilone; Locally advanced; Metastatic; Taxanes

Indexed keywords

AMPRENAVIR; ANTHRACYCLINE; ANTHRACYCLINE DERIVATIVE; BETA TUBULIN; CAPECITABINE; CREMOPHOR; CYTOCHROME P450 3A4; DELAVIRDINE; DOCETAXEL; EPOTHILONE B; EPOTHILONE DERIVATIVE; FLUCONAZOLE; INDINAVIR; ITRACONAZOLE; IXABEPILONE; IXABEPILONE C 14; IXEMPRA; KETOCONAZOLE; NELFINAVIR; PACLITAXEL; RADIOISOTOPE; RITONAVIR; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; VERAPAMIL; VORICONAZOLE;

EID: 53849116502     PISSN: 10521372     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (16)

References (67)
  • 2
    • 26444607816 scopus 로고    scopus 로고
    • Survival of metastatic breast carcinoma patients over a 20-year period: A retrospective analysis based on individual patient data from six consecutive studies
    • Gennari A, Conte P, Rosso R, et al. Survival of metastatic breast carcinoma patients over a 20-year period: A retrospective analysis based on individual patient data from six consecutive studies. Cancer 2005;104:1742-1750.
    • (2005) Cancer , vol.104 , pp. 1742-1750
    • Gennari, A.1    Conte, P.2    Rosso, R.3
  • 3
    • 15544389499 scopus 로고    scopus 로고
    • Chemotherapy: What progress in the last 5 years?
    • Hamilton A, Hortobagyi G. Chemotherapy: What progress in the last 5 years? J Clin Oncol 2005;23:1760-1775.
    • (2005) J Clin Oncol , vol.23 , pp. 1760-1775
    • Hamilton, A.1    Hortobagyi, G.2
  • 4
    • 34147167656 scopus 로고    scopus 로고
    • Achievements in systemic therapies in the pregenomic era in metastatic breast cancer
    • Colozza M, de Azambuja E, Personeni N, et al. Achievements in systemic therapies in the pregenomic era in metastatic breast cancer. Oncologist 2007;12:253-270.
    • (2007) Oncologist , vol.12 , pp. 253-270
    • Colozza, M.1    de Azambuja, E.2    Personeni, N.3
  • 5
    • 27244434470 scopus 로고    scopus 로고
    • Effect of screening and adjuvant therapy on mortality from breast cancer
    • Berry DA, Cronin KA, Plevritis SK, et al. Effect of screening and adjuvant therapy on mortality from breast cancer. N Engl J Med 2005;353:1784-1792.
    • (2005) N Engl J Med , vol.353 , pp. 1784-1792
    • Berry, D.A.1    Cronin, K.A.2    Plevritis, S.K.3
  • 6
    • 0032189117 scopus 로고    scopus 로고
    • Treatment of breast cancer
    • Hortobagyi GN. Treatment of breast cancer. N Engl J Med 1998;339:974-984.
    • (1998) N Engl J Med , vol.339 , pp. 974-984
    • Hortobagyi, G.N.1
  • 7
    • 0037445120 scopus 로고    scopus 로고
    • Are anthracycline-taxane regimens the new standard of care in the treatment of metastatic breast cancer?
    • Valero V, Hortobagyi GN. Are anthracycline-taxane regimens the new standard of care in the treatment of metastatic breast cancer? J Clin Oncol 2003;21:959-962.
    • (2003) J Clin Oncol , vol.21 , pp. 959-962
    • Valero, V.1    Hortobagyi, G.N.2
  • 8
    • 9144268610 scopus 로고    scopus 로고
    • Facts and controversies in systemic treatment of metastatic breast cancer
    • Bernard-Marty C, Cardoso F, Piccart MJ. Facts and controversies in systemic treatment of metastatic breast cancer. Oncologist 2004;9:617-632.
    • (2004) Oncologist , vol.9 , pp. 617-632
    • Bernard-Marty, C.1    Cardoso, F.2    Piccart, M.J.3
  • 9
    • 13644254794 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance
    • Longley DB, Johnston PG. Molecular mechanisms of drug resistance. J Pathol 2005;205:275-292.
    • (2005) J Pathol , vol.205 , pp. 275-292
    • Longley, D.B.1    Johnston, P.G.2
  • 10
    • 28944441595 scopus 로고    scopus 로고
    • Development of novel chemotherapeutic agents to evade the mechanisms of multidrug resistance (MDR)
    • Lee JJ, Swain SM. Development of novel chemotherapeutic agents to evade the mechanisms of multidrug resistance (MDR). Semin Oncol 2005;32(Suppl 7):S22-S26.
    • (2005) Semin Oncol , vol.32 , Issue.SUPPL. 7
    • Lee, J.J.1    Swain, S.M.2
  • 11
    • 28944432804 scopus 로고    scopus 로고
    • Multidrug resistance/P-glycoprotein and breast cancer: Review and meta-analysis
    • Clarke R, Leonessa F, Trock B. Multidrug resistance/P-glycoprotein and breast cancer: Review and meta-analysis. Semin Oncol 2005;32(Suppl 7):S9-S15.
    • (2005) Semin Oncol , vol.32 , Issue.SUPPL. 7
    • Clarke, R.1    Leonessa, F.2    Trock, B.3
  • 12
    • 38449123444 scopus 로고    scopus 로고
    • Fornier M. Epothilones in breast cancer: Review of clinical experience. Ann Oncol 2007;18(Suppl 5):S16-S21.
    • Fornier M. Epothilones in breast cancer: Review of clinical experience. Ann Oncol 2007;18(Suppl 5):S16-S21.
  • 13
    • 28944436711 scopus 로고    scopus 로고
    • Microtubule targeting agents: Basic mechanisms of multidrug resistance (MDR)
    • Fojo AT, Menefee M. Microtubule targeting agents: Basic mechanisms of multidrug resistance (MDR). Semin Oncol 2005;32(Suppl 7):S3-S8.
    • (2005) Semin Oncol , vol.32 , Issue.SUPPL. 7
    • Fojo, A.T.1    Menefee, M.2
  • 14
    • 6444228081 scopus 로고    scopus 로고
    • Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer
    • Faneyte IF, Kristel PM, van de Vijver MJ. Multidrug resistance associated genes MRP1, MRP2 and MRP3 in primary and anthracycline exposed breast cancer. Anticancer Res 2004;24:2931-2939.
    • (2004) Anticancer Res , vol.24 , pp. 2931-2939
    • Faneyte, I.F.1    Kristel, P.M.2    van de Vijver, M.J.3
  • 15
    • 0037314795 scopus 로고    scopus 로고
    • RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: Correlation with chemotherapeutic response
    • Burger H, Foekens JA, Look MP, et al. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: Correlation with chemotherapeutic response. Clin Cancer Res 2003;9:827-836.
    • (2003) Clin Cancer Res , vol.9 , pp. 827-836
    • Burger, H.1    Foekens, J.A.2    Look, M.P.3
  • 16
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006;355:2733-2743.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 17
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • Miller KD, Chap LI, Holmes FA, et al. Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 2005;23:792-799.
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3
  • 18
    • 53849121106 scopus 로고    scopus 로고
    • Ixempra ixabepilone, package insert. Princeton, NJ: Bristol-Myers Squibb; October 2007
    • Ixempra (ixabepilone), package insert. Princeton, NJ: Bristol-Myers Squibb; October 2007.
  • 19
    • 34248228863 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone, a novel epothilone analogue
    • Pivot X, Dufresne A, Villanueva C. Efficacy and safety of ixabepilone, a novel epothilone analogue. Clin Breast Cancer 2007;7:543-549.
    • (2007) Clin Breast Cancer , vol.7 , pp. 543-549
    • Pivot, X.1    Dufresne, A.2    Villanueva, C.3
  • 20
    • 0029049468 scopus 로고
    • Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action
    • Bollag DM, McQueney PA, Zhu J, et al. Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. Cancer Res 1995;55:2325-2333.
    • (1995) Cancer Res , vol.55 , pp. 2325-2333
    • Bollag, D.M.1    McQueney, P.A.2    Zhu, J.3
  • 21
    • 34147112848 scopus 로고    scopus 로고
    • Targeting the microtubules in breast cancer beyond taxanes: The epothilones
    • Cortes J, Baselga J. Targeting the microtubules in breast cancer beyond taxanes: The epothilones. Oncologist 2007;12:271-280.
    • (2007) Oncologist , vol.12 , pp. 271-280
    • Cortes, J.1    Baselga, J.2
  • 22
    • 3843053396 scopus 로고    scopus 로고
    • The binding mode of epothilone A on α,β-tubulin by electron crystallography
    • Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH. The binding mode of epothilone A on α,β-tubulin by electron crystallography. Science 2004;305:866-869.
    • (2004) Science , vol.305 , pp. 866-869
    • Nettles, J.H.1    Li, H.2    Cornett, B.3    Krahn, J.M.4    Snyder, J.P.5    Downing, K.H.6
  • 23
    • 0034895987 scopus 로고    scopus 로고
    • BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy
    • Lee FY, Borzilleri R, Fairchild CR, et al. BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy. Clin Cancer Res 2001;7:1429-1437.
    • (2001) Clin Cancer Res , vol.7 , pp. 1429-1437
    • Lee, F.Y.1    Borzilleri, R.2    Fairchild, C.R.3
  • 24
    • 0037177229 scopus 로고    scopus 로고
    • Epothilone and paclitaxel: Unexpected differences in promoting the assembly and stabilization of yeast microtubules
    • Bode CJ, Gupta ML Jr, Reiff EA, et al. Epothilone and paclitaxel: Unexpected differences in promoting the assembly and stabilization of yeast microtubules. Biochemistry 2002;41:3870-3874.
    • (2002) Biochemistry , vol.41 , pp. 3870-3874
    • Bode, C.J.1    Gupta Jr, M.L.2    Reiff, E.A.3
  • 25
    • 3242717109 scopus 로고    scopus 로고
    • Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein
    • Brooks TA, Minderman H, O'Loughlin KL, et al. Taxane-based reversal agents modulate drug resistance mediated by P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Mol Cancer Ther 2003;2:1195-1205.
    • (2003) Mol Cancer Ther , vol.2 , pp. 1195-1205
    • Brooks, T.A.1    Minderman, H.2    O'Loughlin, K.L.3
  • 26
    • 33746471989 scopus 로고    scopus 로고
    • Novel agents that target tublin and related elements
    • Rowinsky EK, Calvo E. Novel agents that target tublin and related elements. Semin Oncol 2006;33:421-435.
    • (2006) Semin Oncol , vol.33 , pp. 421-435
    • Rowinsky, E.K.1    Calvo, E.2
  • 27
    • 3042701597 scopus 로고    scopus 로고
    • Epothilones: Mechanism of action and biologic activity
    • Goodin S, Kane MP, Rubin EH. Epothilones: Mechanism of action and biologic activity. J Clin Oncol 2004;22:2015-2025.
    • (2004) J Clin Oncol , vol.22 , pp. 2015-2025
    • Goodin, S.1    Kane, M.P.2    Rubin, E.H.3
  • 28
    • 0038811741 scopus 로고    scopus 로고
    • Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days
    • Abraham J, Agrawal M, Bakke S, et al. Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days. J Clin Oncol 2003;21:1866-1873.
    • (2003) J Clin Oncol , vol.21 , pp. 1866-1873
    • Abraham, J.1    Agrawal, M.2    Bakke, S.3
  • 29
    • 12144285977 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors
    • Mani S, McDaid H, Hamilton A, et al. Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res 2004;10:1289-1298.
    • (2004) Clin Cancer Res , vol.10 , pp. 1289-1298
    • Mani, S.1    McDaid, H.2    Hamilton, A.3
  • 30
    • 0001252689 scopus 로고    scopus 로고
    • Phase 1 first-in-man study of epothilone B analog BMS-247550 in patients with advanced cancer (American Society of Clinical Oncology meeting, Abstract 428a)
    • Spriggs DR, Soignet S, Bievenu B, et al. Phase 1 first-in-man study of epothilone B analog BMS-247550 in patients with advanced cancer (American Society of Clinical Oncology meeting, Abstract 428a). Proc Am Soc Clin Oncol 2001;20.
    • (2001) Proc Am Soc Clin Oncol , pp. 20
    • Spriggs, D.R.1    Soignet, S.2    Bievenu, B.3
  • 31
    • 24344450233 scopus 로고    scopus 로고
    • Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design
    • Gadgeel SM, Wozniak A, Boinpally RR, et al. Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design. Clin Cancer Res 2005;11:6233-6239.
    • (2005) Clin Cancer Res , vol.11 , pp. 6233-6239
    • Gadgeel, S.M.1    Wozniak, A.2    Boinpally, R.R.3
  • 32
    • 20244376916 scopus 로고    scopus 로고
    • A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days
    • Zhuang SH, Agrawal M, Edgerly M, et al. A phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days. Cancer 2005;103:1932-1938.
    • (2005) Cancer , vol.103 , pp. 1932-1938
    • Zhuang, S.H.1    Agrawal, M.2    Edgerly, M.3
  • 33
    • 53849085995 scopus 로고    scopus 로고
    • Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients with advanced solid tumors (American Society of Clinical Oncology meeting, Abstract 427)
    • Awada A, Bleiberg H, de Valeriola D, et al. Phase I clinical and pharmacology study of the epothilone analog BMS-247550 given weekly in patients with advanced solid tumors (American Society of Clinical Oncology meeting, Abstract 427). Proc Am Soc Clin Oncol 2001;20.
    • (2001) Proc Am Soc Clin Oncol , pp. 20
    • Awada, A.1    Bleiberg, H.2    de Valeriola, D.3
  • 34
    • 53849133624 scopus 로고    scopus 로고
    • Continuous weekly administration of the epothilone-B derivative, BMS-247550 (NSC710428): A phase I and pharmacokinetic (PK) study (American Society of Clinical Oncology meeting, Abstract 411)
    • Hao D, Hammond LA, deBono JS, et al. Continuous weekly administration of the epothilone-B derivative, BMS-247550 (NSC710428): A phase I and pharmacokinetic (PK) study (American Society of Clinical Oncology meeting, Abstract 411). Proc Am Soc Clin Oncol 2002;21.
    • (2002) Proc Am Soc Clin Oncol , pp. 21
    • Hao, D.1    Hammond, L.A.2    deBono, J.S.3
  • 35
    • 53849113826 scopus 로고    scopus 로고
    • Phase I study of the novel epothilone BMS-247550 administered weekly in patients with advanced malignancies (American Society of Clinical Oncology meeting, Abstract 412)
    • Burris HA, Awada A, Jones S, et al. Phase I study of the novel epothilone BMS-247550 administered weekly in patients with advanced malignancies (American Society of Clinical Oncology meeting, Abstract 412). Proc Am Soc Clin Oncol 2002; 21.
    • (2002) Proc Am Soc Clin Oncol , pp. 21
    • Burris, H.A.1    Awada, A.2    Jones, S.3
  • 36
    • 34548157209 scopus 로고    scopus 로고
    • Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine
    • Perez EA, Lerzo G, Pivot X, et al. Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine. J Clin Oncol 2007;25:3407-3414.
    • (2007) J Clin Oncol , vol.25 , pp. 3407-3414
    • Perez, E.A.1    Lerzo, G.2    Pivot, X.3
  • 37
    • 34548187738 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer
    • Thomas E, Tabernero J, Fornier M, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer. J Clin Oncol 2007;25:3399-3406.
    • (2007) J Clin Oncol , vol.25 , pp. 3399-3406
    • Thomas, E.1    Tabernero, J.2    Fornier, M.3
  • 38
    • 21044441003 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer
    • Low JA, Wedam SB, Lee JJ, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer. J Clin Oncol 2005;23:2726-2734.
    • (2005) J Clin Oncol , vol.23 , pp. 2726-2734
    • Low, J.A.1    Wedam, S.B.2    Lee, J.J.3
  • 39
    • 34548179878 scopus 로고    scopus 로고
    • Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy
    • Roché H, Yelle L, Cognetti F, et al. Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy. J Clin Oncol 2007;25:3415-3420.
    • (2007) J Clin Oncol , vol.25 , pp. 3415-3420
    • Roché, H.1    Yelle, L.2    Cognetti, F.3
  • 40
    • 34548169630 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes
    • Denduluri N, Low JA, Lee JJ, et al. Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes. J Clin Oncol 2007;25:3421-3427.
    • (2007) J Clin Oncol , vol.25 , pp. 3421-3427
    • Denduluri, N.1    Low, J.A.2    Lee, J.J.3
  • 41
    • 53849146572 scopus 로고    scopus 로고
    • Baselga J, Gianni L, Llombart A, et al. Predicting response to ixabepilone: Genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (San Antonio Breast Cancer Symposium, Abstract 305). Breast Cancer Res Treat 2005;94(Suppl 1).
    • Baselga J, Gianni L, Llombart A, et al. Predicting response to ixabepilone: Genomics study in patients receiving single agent ixabepilone as neoadjuvant treatment for breast cancer (San Antonio Breast Cancer Symposium, Abstract 305). Breast Cancer Res Treat 2005;94(Suppl 1).
  • 42
    • 33750456160 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer
    • Denduluri N, Lee JJ, Walshe J, et al. Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer. Invest New Drugs 2007;25:63-67.
    • (2007) Invest New Drugs , vol.25 , pp. 63-67
    • Denduluri, N.1    Lee, J.J.2    Walshe, J.3
  • 43
    • 36849056385 scopus 로고    scopus 로고
    • Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts (American Society of Clinical Oncology meeting, Abstract 12017)
    • Lee FY, Camuso A, Castenada S, et al. Preclinical efficacy evaluation of ixabepilone (BMS-247550) in combination with cetuximab or capecitabine in human colon and lung carcinoma xenografts (American Society of Clinical Oncology meeting, Abstract 12017). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Lee, F.Y.1    Camuso, A.2    Castenada, S.3
  • 44
    • 36849071808 scopus 로고    scopus 로고
    • Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment
    • Thomas ES, Gomez HL, Li RK, et al. Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment. J Clin Oncol 2007;25:5210-5217.
    • (2007) J Clin Oncol , vol.25 , pp. 5210-5217
    • Thomas, E.S.1    Gomez, H.L.2    Li, R.K.3
  • 45
    • 42549115041 scopus 로고    scopus 로고
    • Phase I/II trial in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline: Final safety data (American Society of Clinical Oncology meeting, Abstract 1006)
    • Vahdat L, Klimovsky J, Bunnell C. Phase I/II trial in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline: Final safety data (American Society of Clinical Oncology meeting, Abstract 1006). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Vahdat, L.1    Klimovsky, J.2    Bunnell, C.3
  • 46
    • 34247848547 scopus 로고    scopus 로고
    • Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline (American Society of Clinical Oncology meeting, Abstract 10511)
    • Bunnell C, Klimovsky J, Thomas E. Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline (American Society of Clinical Oncology meeting, Abstract 10511). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Bunnell, C.1    Klimovsky, J.2    Thomas, E.3
  • 47
    • 34548158974 scopus 로고    scopus 로고
    • Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non-small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy
    • Vansteenkiste J, Lara PN Jr, Le Chevalier T, et al. Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non-small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy. J Clin Oncol 2007;25:3448-3455.
    • (2007) J Clin Oncol , vol.25 , pp. 3448-3455
    • Vansteenkiste, J.1    Lara Jr, P.N.2    Le Chevalier, T.3
  • 48
    • 53849129062 scopus 로고    scopus 로고
    • A randomized phase II study of BMS-247550 (ixabepilone) given daily x 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck (American Society of Clinical Oncology meeting, Abstract 5532)
    • Burtness B, Goldwasser MA, Axelrod R, et al. A randomized phase II study of BMS-247550 (ixabepilone) given daily x 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck (American Society of Clinical Oncology meeting, Abstract 5532). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Burtness, B.1    Goldwasser, M.A.2    Axelrod, R.3
  • 49
    • 34547119271 scopus 로고    scopus 로고
    • Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: Randomized phase 2 study of ixabepilone or mitoxantrone and prednisone
    • Rosenberg JE, Weinberg VK, Kelly WK, et al. Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients: Randomized phase 2 study of ixabepilone or mitoxantrone and prednisone. Cancer 2007;110:556-563.
    • (2007) Cancer , vol.110 , pp. 556-563
    • Rosenberg, J.E.1    Weinberg, V.K.2    Kelly, W.K.3
  • 50
    • 53849138539 scopus 로고    scopus 로고
    • A phase II study of a weekly schedule of BMS-247550 for patients with hormone-refractory prostate cancer: A trial of the Eastern Cooperative Oncology Group (E3803) (American Society of Clinical Oncology meeting, Abstract 4618)
    • Liu G, Wang W, Dipaola R, et al. A phase II study of a weekly schedule of BMS-247550 for patients with hormone-refractory prostate cancer: A trial of the Eastern Cooperative Oncology Group (E3803) (American Society of Clinical Oncology meeting, Abstract 4618). J Clin Oncol 2007;24(Suppl 18S).
    • (2007) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Liu, G.1    Wang, W.2    Dipaola, R.3
  • 51
    • 33644843604 scopus 로고    scopus 로고
    • Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: A Southwest Oncology Group trial S0111
    • Hussain M, Tangen CM, Lara PN Jr, et al. Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: A Southwest Oncology Group trial S0111. J Clin Oncol 2005;23:8724-8729.
    • (2005) J Clin Oncol , vol.23 , pp. 8724-8729
    • Hussain, M.1    Tangen, C.M.2    Lara Jr, P.N.3
  • 52
    • 34547865354 scopus 로고    scopus 로고
    • Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): A trial of the Eastern Cooperative Oncology Group
    • Dreicer R, Li S, Manola J, et al. Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): A trial of the Eastern Cooperative Oncology Group. Cancer 2007;110:759-763.
    • (2007) Cancer , vol.110 , pp. 759-763
    • Dreicer, R.1    Li, S.2    Manola, J.3
  • 53
    • 53849091889 scopus 로고    scopus 로고
    • A phase II clinical trial of BMS-247550 (ixabepilone), a microtubule-stabilizing agent in renal cell cancer (American Society of Clinical Oncology meeting, Abstract 4550)
    • Zhuang SH, Menefee M, Kotz H, et al. A phase II clinical trial of BMS-247550 (ixabepilone), a microtubule-stabilizing agent in renal cell cancer (American Society of Clinical Oncology meeting, Abstract 4550). J Clin Oncol 2004;22(Suppl 14S).
    • (2004) J Clin Oncol , vol.22 , Issue.SUPPL. 14S
    • Zhuang, S.H.1    Menefee, M.2    Kotz, H.3
  • 54
    • 34547702867 scopus 로고    scopus 로고
    • Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors
    • Feldman DR, Kondagunta GV, Ginsberg MS, et al. Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors. Invest New Drugs 2007;25:487-490.
    • (2007) Invest New Drugs , vol.25 , pp. 487-490
    • Feldman, D.R.1    Kondagunta, G.V.2    Ginsberg, M.S.3
  • 55
    • 33747689092 scopus 로고    scopus 로고
    • A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone in patients with advanced pancreas cancer: A Southwest Oncology Group study
    • Whitehead RP, McCoy S, Rivkin SE, et al. A phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone in patients with advanced pancreas cancer: A Southwest Oncology Group study. Invest New Drugs 2006;24:515-520.
    • (2006) Invest New Drugs , vol.24 , pp. 515-520
    • Whitehead, R.P.1    McCoy, S.2    Rivkin, S.E.3
  • 56
    • 33745052354 scopus 로고    scopus 로고
    • A multicenter phase II study of BMS-247550 (ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane
    • Ajani JA, Safran H, Bokemeyer C, et al. A multicenter phase II study of BMS-247550 (ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane. Invest New Drugs 2006;24:441-446.
    • (2006) Invest New Drugs , vol.24 , pp. 441-446
    • Ajani, J.A.1    Safran, H.2    Bokemeyer, C.3
  • 57
    • 53849089776 scopus 로고    scopus 로고
    • A phase II trial of the epothilone B analog BMS-247550 in patients with hepatobiliary cancer (HBC): An updated analysis (American Society of Clinical Oncology meeting, Abstract 14050)
    • Singh DA, Taber D, Ansari R, et al. A phase II trial of the epothilone B analog BMS-247550 in patients with hepatobiliary cancer (HBC): An updated analysis (American Society of Clinical Oncology meeting, Abstract 14050). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Singh, D.A.1    Taber, D.2    Ansari, R.3
  • 58
    • 53849125618 scopus 로고    scopus 로고
    • A phase II study of epothilone B analog BMS-247550 (NSC 710426) in patients with relapsed aggressive non-Hodgkin's lymphomas (American Society of Clinical Oncology meeting, Abstract 6625)
    • Smith SM, Pro B, van Besien K, et al. A phase II study of epothilone B analog BMS-247550 (NSC 710426) in patients with relapsed aggressive non-Hodgkin's lymphomas (American Society of Clinical Oncology meeting, Abstract 6625). J Clin Oncol 2005;23(Suppl 16S).
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. 16S
    • Smith, S.M.1    Pro, B.2    van Besien, K.3
  • 59
    • 53849124530 scopus 로고    scopus 로고
    • Targeting the microtubule apparatus in indolent and mantle cell lymphoma with the novel epothilone analog BMS 247550 induces major and durable remissions in very drug resistant disease (American Society of Clinical Oncology meeting, Abstract 6569)
    • O'Connor O, Straus D, Moskowitz C, et al. Targeting the microtubule apparatus in indolent and mantle cell lymphoma with the novel epothilone analog BMS 247550 induces major and durable remissions in very drug resistant disease (American Society of Clinical Oncology meeting, Abstract 6569). J Clin Oncol 2005;23(Suppl 16S).
    • (2005) J Clin Oncol , vol.23 , Issue.SUPPL. 16S
    • O'Connor, O.1    Straus, D.2    Moskowitz, C.3
  • 60
    • 34047212584 scopus 로고    scopus 로고
    • Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas
    • Aghajanian C, Burris HA III, Jones S, et al. Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas. J Clin Oncol 2007;25:1082-1088.
    • (2007) J Clin Oncol , vol.25 , pp. 1082-1088
    • Aghajanian, C.1    Burris III, H.A.2    Jones, S.3
  • 61
    • 53849107647 scopus 로고    scopus 로고
    • A phase I pharmacokinetic (PK) study of the epothilone B analogue, ixabepilone (BMS-247550), in patients with advanced malignancies and varying degrees of hepatic impairment: A Southwest Oncology Group Early Therapeutics Committee and NCI Organ Dysfunction Working Group trial (American Society of Clinical Oncology meeting, Abstract 2004)
    • Takimoto CH, Liu PY, Lenz H, et al. A phase I pharmacokinetic (PK) study of the epothilone B analogue, ixabepilone (BMS-247550), in patients with advanced malignancies and varying degrees of hepatic impairment: A Southwest Oncology Group Early Therapeutics Committee and NCI Organ Dysfunction Working Group trial (American Society of Clinical Oncology meeting, Abstract 2004). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Takimoto, C.H.1    Liu, P.Y.2    Lenz, H.3
  • 62
    • 1542324835 scopus 로고    scopus 로고
    • Management of toxicities associated with the administration of taxanes
    • Markman M. Management of toxicities associated with the administration of taxanes. Expert Opin Drug Saf 2003;2:141-146.
    • (2003) Expert Opin Drug Saf , vol.2 , pp. 141-146
    • Markman, M.1
  • 63
    • 35548983383 scopus 로고    scopus 로고
    • Management and preparedness for infusion and hypersensitivity reactions
    • Lenz HJ. Management and preparedness for infusion and hypersensitivity reactions. Oncologist 2007;12:601-609.
    • (2007) Oncologist , vol.12 , pp. 601-609
    • Lenz, H.J.1
  • 64
    • 34250637078 scopus 로고    scopus 로고
    • Effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone (American Society of Clinical Oncology meeting, Abstract 2005)
    • Goel S, Goldberg G, Iacono LC, et al. Effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone (American Society of Clinical Oncology meeting, Abstract 2005). J Clin Oncol 2006;24(Suppl 18S).
    • (2006) J Clin Oncol , vol.24 , Issue.SUPPL. 18S
    • Goel, S.1    Goldberg, G.2    Iacono, L.C.3
  • 65
    • 34548169077 scopus 로고    scopus 로고
    • Ixabepilone and the narrow path to developing new cytotoxic drugs
    • Gianni L. Ixabepilone and the narrow path to developing new cytotoxic drugs. J Clin Oncol 2007;25:3389-3391.
    • (2007) J Clin Oncol , vol.25 , pp. 3389-3391
    • Gianni, L.1
  • 66
    • 38149032036 scopus 로고    scopus 로고
    • U.S, Available at:, Accessed October 2007
    • ClinicalTrials.gov: a service of the U.S. National Institutes of Health. Available at: www.clinicaltrials.gov. Accessed October 2007.
    • ClinicalTrials.gov: A service of the


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.