Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis

Clinical Immunology

Volumn 129, Issue 2, 2008, Pages 286-294

  Meloni, Francesca ^a   Accapezzato, Daniele ^a   Agresti, Cristina ^b   Aloisi, Francesca ^b   Ristori, Giovanni ^c   Salvetti, Marco ^c   Furlan, Roberto ^d   Martino, Gianvito ^d   Barnaba, Vincenzo ^a   Paroli, Marino ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Apoptosis; Dendritic cells; Multiple sclerosis; Myelin basic protein; Oligodendrocytes; T lymphocytes

Indexed keywords

GAMMA INTERFERON; MYELIN BASIC PROTEIN;

ADULT; AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; HUMAN; HUMAN CELL; MALE; MULTIPLE SCLEROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OLIGODENDROGLIA; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

ADULT; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELLS, CULTURED; CYTOKINES; DENDRITIC CELLS; EPITOPES, T-LYMPHOCYTE; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-DR ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; RATS;

EID: 53749107494     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2008.07.017     Document Type: Article

References (32)

1. Hafler D.A. Multiple sclerosis. J. Clin. Invest. 113 (2004) 788-794
2. Sospedra M., and Martin R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23 (2005) 683-747
3. Olsson T., Sun J., Hillert J., Hojeberg B., Ekre H.P., Andersson G., Olerup O., and Link H. Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis. Eur. J. Immunol. 22 (1992) 1083-1087
4. Lang H.L., Jacobsen H., Ikemizu S., Andersson C., Harlos K., Madsen L., Hjorth P., Sondergaard L., Svejgaard A., Wucherpfennig K., Stuart D.I., Bell J.I., Jones E.Y., and Fugger L. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat. Immunol. 3 (2002) 940-943
5. Bielekova B., Goodwin B., Richert N., Cortese I., Kondo T., Afshar G., Gran B., Eaton J., Antel J., Frank J.A., McFarland H.F., and Martin R. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand. Nat. Med. 6 (2000) 1167-1175
6. Watts C. Capture and processing of exogenous antigens for presentation on MHC molecules. Annu. Rev. Immunol. 15 (1997) 821-850
7. Kivisakk P., Mahad D.J., Callahan M.K., Sikora K., Trebst C., Tucky B., Wujek J., Ravid R., Staugaitis S.M., Lassmann H., and Ransohoff R.M. Expression of CCR7 in multiple sclerosis: implications for CNS immunity. Ann. Neurol. 55 (2004) 627-638
8. Pashenkov M., Huang Y.M., Kostulas V., Haglund M., Soderstrom M., and Link H. Two subsets of dendritic cells are present in human cerebrospinal fluid. Brain 124 (2001) 480-492
9. de Vos A.F., van Meurs M., Brok H.P., Boven L.A., Hintzen R.Q., van der Valk P., Ravid R., Rensing S., Boon L., t Hart B.A., and Laman J.D. Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs. J. Immunol. 169 (2002) 5415-5423
10. Greter M., Heppner F.L., Lemos M.P., Odermatt B.M., Goebels N., Laufer T., Noelle R.J., and Becher B. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11 (2005) 328-334
11. Polman C.H., Reingold S.C., Edan G., Filippi M., Hartung H.P., Kappos L., Lublin F.D., Metz L.M., McFarland H.F., O'Connor P.W., Sandberg-Wollheim M., Thompson A.J., Weinshenker B.G., and Wolinsky J.S. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 58 (2005) 840-846
12. Sturniolo T., Bono E., Ding J., Raddrizzani L., Tuereci O., Sahin U., Braxenthaler M., Gallazzi F., Protti M.P., Sinigaglia F., and Hammer J. Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices. Nat. Biotechnol. 17 (1999) 555-561
13. Singh H., and Raghava G.P. ProPred: prediction of HLA-DR binding sites. Bioinformatics 17 (2001) 1236-1237
14. Fazekas De St. Groth S. The evaluation of limiting dilution assays. J. Immunol. Methods 49 (1982) R11-R23
15. Agresti C., Aloisi F., and Levi G. Heterotypic and homotypic cellular interactions influencing the growth and differentiation of bipotential oligodendrocyte-type-2 astrocyte progenitors in culture. Dev. Biol. 144 (1991) 16-29
16. Agresti C., D'Urso D., and Levi G. Reversible inhibitory effects of interferon-gamma and tumour necrosis factor-alpha on oligodendroglial lineage cell proliferation and differentiation in vitro. Eur. J. Neurosci. 8 (1996) 1106-1116
17. Heath W.R., and Carbone F.R. Cross-presentation in viral immunity and self-tolerance. Nat. Rev. Immunol. 1 (2001) 126-134
18. Guermonprez P., Valladeau J., Zitvogel L., Thery C., and Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20 (2002) 621-667
19. Rawson P.M., Molette C., Videtta M., Altieri L., Franceschini D., Donato T., Finocchi L., Propato A., Paroli M., Meloni F., Mastroianni C.M., d'Ettorre G., Sidney J., Sette A., and Barnaba V. Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection. Nat. Med. 13 (2007) 1431-1439
20. Inaba K., Turley S., Yamaide F., Iyoda T., Mahnke K., Inaba M., Pack M., Subklewe M., Sauter B., Sheff D., Albert M., Bhardwaj N., Mellman I., and Steinman R.M. Efficient presentation of phagocytosed cellular fragments on the major histocompatibility complex class II products of dendritic cells. J. Exp. Med. 188 (1998) 2163-2173
21. Blachere N.E., Darnell R.B., and Albert M.L. Apoptotic cells deliver processed antigen to dendritic cells for cross-presentation. PLoS Biol. 3 (2005) e185
22. Cella M., Sallusto F., and Lanzavecchia A. Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9 (1997) 10-16
23. Rescigno M., Winzler C., Delia D., Mutini C., Lutz M., and Ricciardi-Castagnoli P. Dendritic cell maturation is required for initiation of the immune response. J. Leukoc. Biol. 61 (1997) 415-421
24. Lanzavecchia A., and Sallusto F. Regulation of T cell immunity by dendritic cells. Cell 106 (2001) 263-266
25. Propato A., Cutrona G., Francavilla V., Ulivi M., Schiaffella E., Landt O., Dunbar R., Cerundolo V., Ferrarini M., and Barnaba V. Apoptotic cells overexpress vinculin and induce vinculin-specific cytotoxic T-cell cross-priming. Nat. Med. 7 (2001) 807-813
26. Murry C.E., and Keller G. Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell 132 (2008) 661-680
27. Savill J. Recognition and phagocytosis of cells undergoing apoptosis. Br. Med. Bull. 53 (1997) 491-508
28. Albert M.L., Pearce S.F., Francisco L.M., Sauter B., Roy P., Silverstein R.L., and Bhardwaj N. Immature dendritic cells phagocytose apoptotic cells via alphavbeta5 and CD36, and cross-present antigens to cytotoxic T lymphocytes. J. Exp. Med. 188 (1998) 1359-1368
29. Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., Giuliani F., Arbour N., Becher B., and Prat A. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13 (2007) 1173-1175
30. Casha S., Yu W.R., and Fehlings M.G. Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat. Neuroscience 103 (2001) 203-218
31. Hisahara S., Yuan J., Momoi T., Okano H., and Miura M. Caspase-11 mediates oligodendrocyte cell death and pathogenesis of autoimmune-mediated demyelination. J. Exp. Med. 193 (2001) 111-122
32. Krogsgaard M., Wucherpfennig K.W., Cannella B., Hansen B.E., Svejgaard A., Pyrdol J., Ditzel H., Raine C., Engberg J., and Fugger L. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex. J. Exp. Med. 191 (2000) 1395-1412