Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9554-9573

  Barrett, Irene ^a   Meegan, Mary J ^a   Hughes, Rosario B ^a   Carr, Miriam ^a   Knox, Andrew J S ^a   Artemenko, Natalia ^a   Golfis, Georgia ^a   Zisterer, Daniela M ^a   Lloyd, David G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Antiproliferative activity; Benzoxepin; Docking; Estrogen receptor antagonist; QSAR

Indexed keywords

4 (4 HYDROXYPHENYL) 5 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 2,3 DIHYDROBENZO[B]OXEPIN 8 OL; 4 [8 FLUORO 5 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 2,3 DIHYDROBENZO[B]OXEPIN 4 YL]PHENOL; 4 HYDROXYTAMOXIFEN; [4 [8 FLUORO 4 [4 (2 PYRROLIDIN 1 YLETHOXY)PHENYL] 2,3 DIHYDROBENZO[B]OXEPIN 5 YL]PHENOL; BENZOXEPIN DERIVATIVE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ETHYLENE DERIVATIVE; FLUORINE DERIVATIVE; FUNCTIONAL GROUP; HETEROCYCLIC COMPOUND; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LIPOPHILICITY; MOLECULAR DOCKING; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR AFFINITY;

BENZOXEPINS; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGEN RECEPTOR MODULATORS; FEMALE; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TUMOR CELLS, CULTURED;

EID: 53749107256     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.035     Document Type: Article

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