Circulating tumor cells in breast cancer: Methodology and clinical repercussions

Clinical and Translational Oncology

Volumn 10, Issue 7, 2008, Pages 399-406

  Gasent Blesa, Joan Manel ^a   Alberola Candel, Vicente ^b   Esteban González, Emilio ^c   Vidal Martínez, José ^b   Gisbert Criado, Rafael ^b   Provencio Pulla, Mariano ^d   Laforga Canales, Juan ^a   Pachmann, Katharina ^e  

^a HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^b Arnau Hospital of Vilanova   (Spain)

^c HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^d HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^e FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Breast cancer; Circulating tumour cells; Clinical implications

Indexed keywords

BLOOD; BLOOD EXAMINATION; BREAST TUMOR; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMAN; IMMUNOHISTOCHEMISTRY; METHODOLOGY; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TUMOR EMBOLISM;

BREAST NEOPLASMS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOLOGIC TESTS; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM CIRCULATING CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 53749103204     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-008-0222-9     Document Type: Article

References (36)

1. Greenberg PA, Hortobagyi GN, Smith TL et al (1996) Long-term follow-up of patients with complete remission following combination chemotherapy for metastatic breast cancer. J Clin Oncol 14: 2197-2205
2. Pierga JY, Bonneton Ch, Vincent-Slamon A et al (2004) Clinical significance of immunocytochemical detection of tumor cells using digital microscopy in peripheral blood and bone marrow of breast cancer patients. Clin Can Res 10:1392-1400
3. Braun S, Pantel K, Müller P et al (2000) Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer patients. N Engl J Med 342:525-534
4. Braun S, Voglt F, Naume B et al (2005) A pooled analyses of Bone Marrow micrometastases in breast cancer. N Engl J Med 353:793-802
5. Borgen E, Naume B, Nesland JM et al (1999) Standardization of the immunocytochemical detection of cancer cells in BM and blood: I. establishment of objective criteria for the evaluation of immunostained cells. The European ISHAGE Working Group for Standardization of Tumor Cell Detection. Cytotherapy 1:377-388
6. Kagan M, Howard D, Bendele T et al (2002) A sample preparation and analysis system for identification of circulating tumor cells. J Clin Ligand Assay 25:104-110
7. Kagan M, Howard D, Bendele T et al (2002) Circulating tumor cells as cancer markers. In: Diamandis EP, Fritsche HA, Lilja H et al (eds) Tumor markers: physiology, pathobiology, technology, and clinical applications. Washington, D.C. AACC Press pp 495-498
8. Allard WJ, Matera J, Miller MC et al (2004) Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with non-malignant diseases. Clin Cancer Res 10:6897-6904
9. Stopeck A., Cristofanilli M, Budd T et al (2006) Circulating tumor cells - not serum tumor markers - predict survival in metastatic breast cancer. Proc Am Soc Clin Oncol Abst 9516
10. Pachmann K, Heiss P, Demel U, Tilz G (2001) Detection and quantification of small numbers of circulating tumour cells in peripheral blood using laser scanning cytometer (LSC). Clin Chem Lab Med 39(9):811-817
11. Pachmann K, Clement JH, Schneider CP et al (2005) Standardized quantification of circulating peripheral tumor cells from lung and breast cancer. Clin Chem Lab Med 43(6):617-627
12. Naito H, Kuzumaki N, Uchino J et al (1991) Detection of tyrosine hydroxylase mRNA and minimal neuroblastoma cells by the reverse transcription-polymerase chain reaction. Eur J Cancer 27: 762-765
13. Wood DP Jr, Banks ER, Humphreys S, et al (1994) Sensitivity of immunohistochemistry and polymerase chain reaction in detecting prostate cancer cells in bone marrow. J Histochem Cytochem 42:505-511
14. Sabbatini R, Federico M, Morselli M et al (2000) Detection of circulating tumor cells by reverse transcriptase polymerase chain reaction of maspin in patients with breast cancer undergoing conventional-dose chemotherapy. J Clin Oncol 14:1914-1920
15. Smith BM, Slade MJ, English J et al (2000) Response of circulating tumor cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques. J Clin Oncol 18:1432-1439
16. Umetani N, Giuliano LE, Hiramatsu SH et al (2006) Prediction of breast tumor progression by integrity of free-circulating DNA in serum. J Clin Oncol 24: 4270-4276
17. Lander ES, Linton LM, Birren B et al (2001) Initial sequencing and analysis of the human genome. Nature 409:860-921
18. Smirnov DA, Zweitig DR, Foulk OPW et al (2005) Global gene expression profiling of circulating tumor cells. Cancer Res 65:4993-4997
19. Smerage JB, Hayes DF, Doyle GV et al (2006) Assessment of circulating tumor cells in breast cancer patients undergoing neoadjuvant chemotherapy. Proc Am Soc Clin Oncol Abst 10079
20. Pierga JY, Mathiot C, Extra JM et al (2006). Circulating tumor cells (CTCs) detection in a randomized phase II trial of neoadjuvant chemotherapy for large operable and locally advanced breast cancer (REMAGUS 02): Preliminary results. Proc Am Soc Clin Oncol Abstr 10637
21. Camara O, Rengesberger M, Egbe A et al (2007). The relevance of circulating epithelial tumor cells (CETC) for therapy monitoring during neoadjuvant (primary systemic) chemotherapy in breast cancer. Ann Oncol 18:1484-1492
22. Müller V, Stahmann N, Riethdorf S et al (2005) Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity. 11:3678-3685
23. Pachmann K, Camara O, Lobodasch K et al (2006) Circulating tumor cells, tools for monitoring and targets for therapy. J Clin Oncol 24(18S): 32
24. Pachmann K, Camara O, Kavallaris A et al (2008) Monitoring the response of circulating epithelial tumor cells (CETC) to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse. J Clin Oncol 26(8):1208-1215
25. Xenidis N, Mavroudis D, Apostolaki S et al (2006) Effect of adjuvant treatment on the circulating ck-19 mRNA-positive tumor cells in patients with early breast cancer. Proc Am Soc Clin Oncol Abstr 20012
26. Lobodasch K, Fröhlich F, Rengsberger M et al (2007) Quantification of circulating tumour cells for the monitoring of adjuvant therapy in breast cancer: an increase in cell number at completion of therapy is a predictor of early relapse. Breast 6: 211-218
27. Meng S, Tripathy D, Eugene P et al (2004) Circulating tumor cells in patients with breast cancer dormancy. Clin Can Res 10:8152-8162
28. Pachmann CCR, Pachmann K (2005) Longtime recirculating tumor cells in breast cancer patients. Clin Can Res 11:5657-5658
29. Cristofanilli M, Budd Th, Ellis M J et al (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351:781-791
30. Cistofanilli M, Hayes D, Budd Th et al (2005) Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 23:1420-1430
31. Budd Th, Cristofanilli M, Ellis MJ et al (2006) Circulating tumor cells versus imaging, predicting overall survival in metastatic breast cancer. Clin Can Res 12:6403, 6409
32. Cristofanilli M, Guarneri V, Valero V et al (2006) Circulating tumour cells (CTC's) in metastatic breast cancer: Biological value beyond tumour burden. Proc Am Soc Clin Oncol (Abstr) 615
33. Meng S, Tripathy D, Shete S et al (2004) HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci 101:9393-9398
34. Datta YH, Adams PT, Drobyski WR et al (1994) Sensitive detectionof occult breast cancer by reverse-transcriptase polymerase chain reaction. J Clin Oncol 12:475-482
35. Zippelius A, Kufer P, Honold G et al (1997) Limitations of reverse transcriptase polymerase chain reaction analysis for detection of micrometastatic epithelial cancer cells in bone marrow. J Clin Oncol 15:2701-2708
36. Harris L, Fritsche H, Mennel R (2007) American Society of Clinical Oncology. Update of recommendations for the use of tumor markers in breast cancer. J Clin Onc 5287-5312