Effects of enzyme sources on midazolam 1′-hydroxylation activity catalyzed by recombinant cytochrome P450 3A4 in combination with NADPH-cytochrome P450 reductase

Drug Metabolism Letters

Volumn 2, Issue 3, 2008, Pages 190-192

  Emoto, Chie ^a   Murayama, Norie ^a   Yamazaki, Hiroshi ^a  

^a SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Bicistronic expression; CYP3A4; E. coli membranes; Human; Lipid mixtures; NADPH P450 reductase

Indexed keywords

CYTOCHROME P450 3A4; MIDAZOLAM; PHOSPHOLIPID; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE;

ARTICLE; BACTERIAL MEMBRANE; CATALYSIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ESCHERICHIA COLI; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL MEMBRANE; CYTOCHROME P-450 CYP3A; DNA, COMPLEMENTARY; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; HYDROXYLATION; MIDAZOLAM; NADPH-FERRIHEMOPROTEIN REDUCTASE; PHOSPHOLIPIDS;

EID: 53749101365     PISSN: 18723128     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231208785425737     Document Type: Article

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