No variation of physical performance and perceived exertion after adrenal gland stimulation by synthetic ACTH (Synacthen®) in cyclists

European Journal of Applied Physiology

Volumn 104, Issue 4, 2008, Pages 589-600

  Baume, Norbert ^a,f   Steel, Graeme ^b   Edwards, Tony ^c   Thorstensen, Eric ^d   Miller, Benjamin F ^e  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b Drug Free Sport NZ   (New Zealand)

^c Adidas Sports Medicine   (New Zealand)

^d THE UNIVERSITY OF AUCKLAND   (New Zealand)

^e Department of Environmental and Radiological Health Sciences   (United States)

^f Swiss Laboratory for Doping Analyses   (Switzerland)

Author keywords

ACTH; Androgens; Cortisol; Cycling; Doping

Indexed keywords

ANDROGEN; CORTICOTROPIN; PLACEBO; TETRACOSACTIDE;

ADRENAL GLAND; ADULT; ANDROGEN BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; CORTICOTROPIN TEST; CYCLING; DOPING; DRUG ABUSE; EXERCISE TEST; FATIGUE; HORMONE URINE LEVEL; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PHYSICAL PERFORMANCE; PRIORITY JOURNAL; TASK PERFORMANCE; URINALYSIS;

ADRENAL GLANDS; ADRENOCORTICOTROPIC HORMONE; ADULT; ATHLETIC PERFORMANCE; BICYCLING; CROSS-OVER STUDIES; DEHYDROEPIANDROSTERONE; DOUBLE-BLIND METHOD; GLUCOCORTICOIDS; GLUCURONIDES; HEART RATE; HUMANS; HYDROCORTISONE; MALE; PHYSICAL EXERTION; TESTOSTERONE;

EID: 53749095934     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-008-0802-y     Document Type: Article

References (50)

1. Abdi S, Datta S, Trescot AM, Schultz DM, Adlaka R, Atluri SL et al (2007) Epidural steroids in the management of chronic spinal pain: A systematic review. Pain Physician 10(1):185-212
2. Aguilera G, Kiss A, Liu Y, Kamitakahara A (2007) Negative regulation of corticotropin releasing factor expression and limitation of stress response. Stress 10(2):153-161. doi: 10.1080/10253890701391192
3. Bogdanov AI, Yarushkina NI (2004) The role of adrenocorticotropic hormone in the inhibition of pain reactions in conscious rats. Neurosci Behav Physiol 34:575-578. doi: 10.1023/B:NEAB.0000028287.61380.05
4. Borg GA (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14:377-381
5. Bourgogne E, Herrou V, Mathurin JC, Becchi M, de Ceaurriz J (2000) Detection of exogenous intake of natural corticosteroids by gas chromatography/combustion/isotope ratio mass spectrometry: Application to misuse in sport. Rapid Commun Mass Spectrom 14(24):2343-2347. doi:10.1002/1097-0231(20001230)14:24<2343::AID-RCM171>3.0.CO;2-Z
6. Brooks RV, Giuliani G (1964) Epitestosterone: Isolation from human urine and experiments on possible precursors. Steroids 4:101-116. doi: 10.1016/ 0039-128X(64)90028-5
7. Burke LM, Hawley JA (2002) Effects of short-term fat adaptation on metabolism and performance of prolonged exercise. Med Sci Sports Exerc 34(9):1492-1498. doi: 10.1097/00005768-200209000-00015
8. Catlin DH, Hatton CK, Starcevic SH (1997) Issues in detecting abuse of xenobiotic anabolic steroids and testosterone by analysis of athletes urine. Clin Chem 43:1280-1288
9. Clarkson PM, Thompson HS (1997) Drugs and sport: Research findings and limitations. Sports Med 24(6):366-384. doi: 10.2165/ 00007256-199724060-00003
10. Dehennin L (1993) Secretion by human testis of epitestosterone with its sulfoconjugate and precursor androgen 5-androstene-3b, 17a-diol. J Steroid Biochem Mol Biol 44:171-177. doi: 10.1016/0960-0760(93)90025-R
11. Duclos M, Corcuff JB, Pehourcq F, Tabarin A (2001) Decreased pituitary sensitivity to glucocorticoids in endurance-trained men. Eur J Endocrinol 144(4):363-368. doi: 10.1530/eje.0.1440363
12. Duclos M, Gouarne C, Bonnemaison D (2003) Acute and chronic effects of exercise on tissue sensitivity to glucocorticoids. J Appl Physiol 94(3):869-875
13. Dunn AL, Marcus BH, Kampert JB, Garcia ME, Kohl HW 3rd, Blair SN (1999) Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: A randomized trial. JAMA 281(4):327-334. doi: 10.1001/jama.281.4.327
14. Dvorak J, Feddermann N, Grimm K (2006) Glucocorticosteroids in football: use and misuse. Br J Sports Med 40(Suppl 1):i48-i54. doi: 10.1136/ bjsm.2006.027599
15. Ferrando AA, Stuart CA, Sheffield-Moore M, Wolfe RR (1999) Inactivity amplifies the catabolic response of skeletal muscle to cortisol. J Clin Endocrinol Metab 84:3515-3521. doi: 10.1210/jc.84.10.3515
16. Fitch KD (1986) The use of anti-asthmatic drugs. Do they affect sports performance? Sports Med 3:136-150. doi: 10.2165/00007256-198603020-00004
17. Horton R, Tait JF (1966) Androstenedione production and interconversion rates measured in peripheral blood and studies on the possible site of its conversion to testosterone. J Clin Invest 45:301-313. doi: 10.1172/ JCI105344
18. Johnson KL, Renn C (2006) The hypothalamic-pituitary-adrenal axis in critical illness. AACN Clin Issues 17:39-49. doi: 10.1097/ 00044067-200601000-00006
19. Kicman AT, Coutts SB, Cowan DA, Handelsman DJ, Howe CJ, Burring S et al (1999) Adrenal and gonadal contributions to urinary excretion and plasma concentration of epitestosterone in men-effect of adrenal stimulation and implications for detection of testosterone abuse. Clin Endocrinol (Oxf) 50:661-668. doi: 10.1046/j.1365-2265.1999.00742.x
20. Luger A, Deuster PA, Kyle SB, Gallucci WT, Montgomery LC, Gold PW et al (1987) Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise: Physiologic adaptations to physical training. N Engl J Med 316:1309-1315
21. Marfell-Jones M (2000) Kinanthropometric assessment. In: Bishop B, Hume P (eds) Guidelines for athlete assessment in New Zealand Sport, Sports Science New Zealand
22. Mazzarino M, Rossi F, Giacomelli L, Botrè F (2006) Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by gas chromatography-mass spectrometry. Anal Chim Acta 559:30-36. doi: 10.1016/j.aca.2005.11.002
23. Medsafe, NZ (2006) Consumer Medicine Information
24. Mujika I, Padilla S (2001) Physiological and performance characteristics of male professional road cyclists. Sports Med 31(7):479-487. doi: 10.2165/00007256-200131070-00003
25. Nichols AW (2005) Complications associated with the use of corticosteroids in the treatment of athletic injuries. Clin J Sport Med 15:370-375. doi: 10.1097/01.jsm.0000179233.17885.18
26. Nieman LK, Chanco Turner ML (2006) Addison's disease. Clin Dermatol 24(4):276-280. doi: 10.1016/j.clindermatol.2006.04.006
27. Palmer GS, Dennis SC, Noakes TD, Hawley JA (1996) Assessment of the reproducibility of performance testing on an air-braked cycle ergometer. Int J Sports Med 17(4):293-298. doi: 10.1055/s-2007-972849
28. Palonek E, Gottlieb C, Garle M, Björkhem I, Carlström K (1995) Serum and urinary markers of exogenous testosterone administration. J Steroid Biochem Mol Biol 55:121-127. doi: 10.1016/0960-0760(95)00146-Q
29. Phillipov G (1998) Effect of hypercortisolism and ACTH on the metabolism of cortisol. Exp Clin Endocrinol Diabetes 106:57-60
30. Polettini A, Marrubini Bouland G, Montagna M (1998) Development of a coupled-column liquid chromatographic-tandem mass spectrometric method for the direct determination of betamethasone in urine. J Chromatogr B Biomed Sci Appl 713(2):339-352. doi: 10.1016/S0378-4347(98)00177-7
31. Reed MJ, Beranek PA, Cheng RW, Few JD, James VH (1987) The effect of cortisol or ACTH on plasma concentrations of free fatty acids. In Vivo 1:181-184
32. Ricketts ML, Verhaeg JM, Bujalska I, Howie AJ, Rainey WE, Stewart PM (1998) Immunohistochemical localization of type 1 11beta-hydroxysteroid dehydrogenase in human tissues. J Clin Endocrinol Metab 83:1325-1335. doi: 10.1210/jc.83.4.1325
33. Rook GA (1999) Glucocorticoids and immune function. Best Pract Res Clin Endocrinol Metab 13:567-581. doi: 10.1053/beem.1999.0044
34. Sapolsky RM, Romero LM, Munck AU (2000) How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21(1):55-89. doi: 10.1210/er.21.1.55
35. Schabort EJ, Hawley JA, Hopkins WG, Mujika I, Noakes TD (1998) A new reliable laboratory test of endurance performance for road cyclists. Med Sci Sports Exerc 30:1744-1750. doi: 10.1097/00005768-199812000-00014
36. Schaison G, Durand F, Mowszowicz I (1978) Effect of glucocorticoids on plasma testosterone in men. Acta Endorcinol. 89:126-131
37. Sewer MB, Waterman MR (2003) ACTH modulation of transcription factors responsible for steroid hydroxylase gene expression in the adrenal cortex. Microsc Res Tech 61:300-307. doi: 10.1002/jemt.10339
38. Soetens E, De Meirleir K, Hueting JE (1995) No influence of ACTH on maximal performance. Psychopharmacology (Berl) 118:260-266. doi: 10.1007/ BF02245953
39. Sottas PE, Saudan C, Schweizer C, Baume N, Mangin P, Saugy M (2008) From population- to subject-based limits of T/EPIT ratio to detect testosterone abuse in elite sports. Forensic Sci Int 174(2-3):166-172. doi: 10.1016/j.forsciint.2007.04.001
40. Tamm J, Apostolakis M, Voigt KD (1966) The effects of ACTH and HCG on the urinary excretion of testosterone in male patients with various endocrine disorders. Acta Endocrinol (Copenh) 53:61-72
41. Thevis M, Bredehoft M, Geyer H, Kamber M, Delahaut P, Schanzer W (2006) Determination of Synacthen in human plasma using immunoaffinity purification and liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 20:3551-3556. doi: 10.1002/rcm.2774
42. Tremblay MS, Copeland JL, Van Helder W (2005) Influence of exercise duration on post-exercise steroid hormone responses in trained males. Eur J Appl Physiol 94(5-6):505-513. doi: 10.1007/s00421-005-1380-x
43. Viru A, Viru M (2004) Cortisol - essential adaptation hormone in exercise. Int J Sports Med 25(6):461-464. doi: 10.1055/s-2004-821068
44. Vogeser M, Zachoval R, Jacob K (2001) Serum cortisol/cortisone ratio after Synacthen stimulation. Clin Biochem 34:421-425. doi: 10.1016/ S0009-9120(01)00251-X
45. Voigt K, Ziegler M, Grunert-Fuchs M, Bickel U, Fehm-Wolfsdorf G (1990) Hormonal responses to exhausting physical exercise: The role of predictability and controllability of the situation. Psychoneuroendocrinology 15:173-184. doi: 10.1016/0306-4530(90)90028-8
46. WADA (2004) WADA Technical Document: Reporting and evaluation guidance for testosterone, epitestosterone, T/E ratio and other endogenous steroids, http://www.wada-ama.org.
47. WADA (2008) The 2008 prohibited list. The World Anti-Doping Code 2008. http://www.wada-ama.org
48. Weitzman ED, Fukushima C, Nogeire C (1971) Twenty-four-hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 33:14-22
49. Wilson H, Lipsett MB (1966) Metabolism of epitestosterone in man. J Clin Endocrinol 26:902-914
50. Wood JB, Frankland AW, James VH, Landon J (1965) A Rapid test of adrenocortical function. Lancet 191:243-245. doi: 10.1016/ S0140-6736(65)91526-6