Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: A controlled clinical study

Journal of Clinical Periodontology

Volumn 30, Issue 6, 2003, Pages 496-504

  Wachtel, Hannes ^a,b   Schenk, Günther ^b   Böhm, Sonja ^b,c   Weng, Dietmar ^d,e   Zuhr, Otto ^b   Hürzeler, Markus B ^b,d,f  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Priv Inst Periodontol I   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

^d UNIVERSITY OF TEXAS   (United States)

^e UNIVERSITY OF WÜRZBURG   (Germany)

^f UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Controlled clinical study; Early wound healing index; Emdogain ; Enamel matrix derivative; Intrabony defects; Microsurgical access flap; Periodontal regeneration

Indexed keywords

ADULT; ARTICLE; BONE DEFECT; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ENAMEL; EVALUATION; FEMALE; HUMAN; MALE; MICROSURGERY; MOUTH HYGIENE; PERIODONTAL DISEASE; PERIODONTICS; RANDOMIZATION; WOUND HEALING; ANALYSIS OF VARIANCE; GINGIVA DISEASE; METHODOLOGY; MIDDLE AGED; ORAL SURGERY; OSTEOLYSIS; PLASTIC SURGERY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TOOTH PLAQUE;

ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN;

ADULT; ALVEOLAR BONE LOSS; ANALYSIS OF VARIANCE; DENTAL ENAMEL PROTEINS; DENTAL PLAQUE INDEX; FEMALE; GINGIVAL RECESSION; HUMANS; MALE; MICROSURGERY; MIDDLE AGED; ORAL SURGICAL PROCEDURES; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL INDEX; PROSPECTIVE STUDIES; SINGLE-BLIND METHOD; SURGICAL FLAPS; WOUND HEALING;

EID: 0042883866     PISSN: 03036979     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-051X.2003.00013.x     Document Type: Article

References (39)

1. Cortellini, P., Pini Prato, G. & Tonetti, M. (1993) Periodontal regeneration of human intrabony defects. I. Clinical measures. Journal of Periodontology 64, 254-260.
2. Cortellini, P., Pini Prato, G. & Tonetti, M. (1995a) Periodontal regeneration of human intrabony defects with titanium reinforced membranes. Journal of Periodontology 66, 797-803.
3. Cortellini, P., Pini Prato, G. & Tonetti, M. (1995b) The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. Journal of Periodontology 66, 261-266.
4. Cortellini, P., Pini Prato, G. & Tonetti, M. (1996) Periodontal regeneration of human intrabony defects with bioresorbable membranes. Journal of Periodontology 67, 217-223.
5. Cortellini, P., Pini Prato, G. & Tonetti, M. (1999) The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. International Journal of Periodontics & Restorative Dentistry 19, 589-599.
6. Cortellini, P. & Tonetti, M. S. (2001) Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. Journal of Periodontology 72, 559-569.
7. De Sanctis, M., Zucchelli, G. & Clauser, C. (1996a) Bacterial colonization of barrier material and periodontal regeneration. Journal of Clinical Periodontology 23, 1039-1046.
8. De Sanctis, M., Zucchelli, G. & Clauser, C. (1996b) Bacterial colonization of bioabsorbable barrier material and periodontal regeneration. Journal of Periodontology 67, 1193-1200.
9. Falk, H., Laurell, L., Ravald, N., Teiwik, A. & Persson, R. (1997) Guided tissue regeneration therapy of 203 consecutively treated intrabony defects using a bioabsorbable matrix barrier. Clinical and radiographic findings. Journal of Periodontology 68, 571-581.
10. Froum, S., Weinberg, M., Rosenberg, E. & Tarnow, D. (2001) A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: a 12-month re-entry study. Journal of Periodontology 72, 25-34.
11. Gottlow, J., Nyman, S., Lindhe, J., Karring, T. & Wennström, J. (1986) New attachment formation in the human periodontium by guided tissue regeneration. Case reports. Journal of Clinical Periodontology 13, 604-616.
12. Hammarström, L. (1997) Enamel matrix, cementum development and regeneration. Journal of Clinical Periodontology 24, 658-668.
13. Hammarström, L., Heijl, L. & Gestrelius, S. (1997) Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. Journal of Clinical Periodontology 24, 669-677.
14. Heden, G., Wennström, J. & Lindhe, J. (1999) Periodontal tissue alterations following Emdogain® treatment of periodontal sites with angular bone defects. A series of case reports. Journal of Clinical Periodontology 26, 855-860.
15. Heijl, L., Heden, G., Svärdström, G. & Östgren, A. (1997) Enamel matrix derivative (EMDOGAIN®) in the treatment of intrabony periodontal defects. Journal of Clinical Periodontology 24, 705-714.
16. Hugoson, A., Ravald, N., Fornell, J., Johard, G., Teiwik, A. & Gottlow, J. (1995) Treatment of class II furcation involvements in humans with bioresorbable and non-resorbable guided tissue regeneration barriers. A randomized multi-center study. Journal of Periodontology 66, 624-634.
17. Kornman, K. & Robertson, P. (2000) Fundamental principles affecting the outcomes of therapy for osseous lesions. Periodontology 2000 22, 22-43.
18. Lange, D., Plagmann, H., Eenboom, A. & Promesberger, A. (1977) Clinical methods for the objective evaluation of oral hygiene. Deutsche Zahnärztliche Zeitschrift 32, 44-47.
19. Laurell, L., Gottlow, J., Zybutz, M. & Persson, R. (1998) Treatment of intrabony defects by different surgical procedures. A literature review. Journal of Periodontology 69, 303-313.
20. Machtei, E., Cho, M., Dunford, R., Norderyd, J., Zambon, J. & Genco, R. (1994) Clinical, microbiological, and histological factors which influence the success of regenerative periodontal therapy. Journal of Periodontology 65, 154-161.
21. Mellonig, J. (1999) Enamel matrix derivative for periodontal reconstructive surgery: Technique and clinical and histologic case report. International Journal of Periodontics & Restorative Dentistry 19, 9-19.
22. Nowzari, H., Matian, F. & Slots, J. (1995) Periodontal pathogens on polytetrafluoroethylene membrane for guided tissue regeneration inhibit healing. Journal of Clinical Periodontology 22, 469-474.
23. Nyman, S., Gottlow, J., Karring, T. & Lindhe, J. (1982a) The regenerative potential of the periodontal ligament. An experimental study in the monkey. Journal of Clinical Periodontology 9, 257-265.
24. Nyman, S., Lindhe, J., Karring, T. & Rylander, H. (1982b) New attachment following surgical treatment of human periodontal disease. Journal of Clinical Periodontology 9, 290-296.
25. Okuda, K., Momose, M., Miyazaki, A., Murata, M., Yokoyama, S., Yonezawa, Y., Wolff, L. & Yoshie, H. (2000) Enamel matrix derivative in the treatment of human intrabony osseous defects. Journal of Periodontology 71, 1821-1828.
26. Pontoriero, R., Wennström, J. & Lindhe, J. (1999) The use of barrier membranes and enamel matrix proteins in the treatment of angular bone defects. A prospective controlled clinical study. Journal of Clinical Periodontology 26, 833-840.
27. Sculean, A., Chiantella, G., Windisch, P. & Donos, N. (2000) Clinical and histologic evaluation of treatment of intrabony defects with an enamel matrix protein derivative Emdogain®. International Journal of Periodontics & Restorative Dentistry 20, 375-381.
28. Sculean, A., Donos, N., Blaes, A., Lauermann, M., Reich, E. & Brecx, M. (1999a) Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony defects. A split-mouth study. Journal of Periodontology 70, 255-262.
29. Sculean, A., Donos, N., Windisch, P., Gera, I., Brecx, M., Reich, E. & Karring, T. (1999b) Healing of human intrabony defects following treatment with enamel matrix proteins or guided tissue regeneration. Journal of Periodontal Research 34, 310-322.
30. Sculean, A., Windisch, P., Chiantella, G., Donos, N., Brecx, M. & Reich, E. (2001) Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study. Journal of Clinical Periodontology 28, 397-403.
31. Selvig, K., Kersten, B., Chamberlain, A., Wikesjö, U. & Nilveus, R. (1992) Regenerative surgery of intrabony periodontal defects using ePTFE barrier membranes. Scanning electron microscopic evaluation of retrieved membranes versus clinical healing. Journal of Periodontology 63, 974-978.
32. Takei, H., Han, T., Carranza, F. Jr., Kenney, E. & Lekovic, V. (1985) Flap technique for periodontal bone implants. Papilla preservation technique. Journal of Periodontology 56, 204-210.
33. Tibbetts, L. S. & Shanelec, D. (1998) Periodontal microsurgery. Dental Clinics of North America 42, 339-359.
34. Tonetti, M., Pini Prato, G. & Cortellini, P. (1993) Periodontal regeneration of human intrabony defects. IV. Determinants of the healing response. Journal of Periodontology 64, 934-940.
35. Tonetti, M., Pini Prato, G. & Cortellini, P. (1995) Effect of cigarette smoking on periodontal healing following GTR in infrabony defects. A preliminary retrospective study. Journal of Clinical Periodontology 22, 229-234.
36. Tonetti, M., Pini Prato, G. & Cortellini, P. (1996) Factors affecting the healing response of intrabony defects following guided tissue regeneration and access flap surgery. Journal of Clinical Periodontology 23, 548-556.
37. Van der Pauw, M., Van den Bos, T., Everts, V. & Beertsen, W. (2000) Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor β1 release of periodontal ligament and gingival fibroblasts. Journal of Periodontology 71, 31-43.
38. Yukna, R. & Mellonig, J. (2000) Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series. Journal of Periodontology 71, 752-759.
39. Zucchelli, G., De Sanctis, M. & Clauser, C. (1997) Integrated connective tissue in bioabsorbable barrier material and periodontal regeneration. Journal of Periodontology 68, 996-1004.