[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrils

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5701-5704

  Lee, Ji Hoon ^a,b   Byeon, Seong Rim ^a   Kim, YoungSoo ^a   Lim, Soo Jeong ^c   Oh, Seung Jun ^c   Moon, Dae Hyuk ^c   Yoo, Kyung Ho ^a   Chung, Bong Young ^b   Kim, Dong Jin ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Korea University   (South Korea)

^c Asan Medical Center   (South Korea)

Author keywords

18F labeled; Alzheimer's Disease; Imaging probe; PET

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN[1-42]; FLUORINE 18; INDOLE DERIVATIVE; ISOINDOL 1 ONE DERIVATIVE; ISOINDOL 1,3 DIONE DERIVATIVE; ISOINDOLE DERIVATIVE; N MONOMETHYLISOINDOLE DERIVATIVE; N,N DIMETHYLISOINDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING COMPETITION; DIAGNOSTIC IMAGING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; POSITRON EMISSION TOMOGRAPHY; PROTEIN DETERMINATION;

AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; BINDING, COMPETITIVE; BRAIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; FLUORINE RADIOISOTOPES; HUMANS; ISOINDOLES; KINETICS; MICE; MODELS, CHEMICAL; POSITRON-EMISSION TOMOGRAPHY; SENILE PLAQUES;

EID: 53549126618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.019     Document Type: Article

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