Synthesis and evaluation of two 18F-labeled imidazo[1,2-a]pyridine analogues as potential agents for imaging β-amyloid in Alzheimer's disease

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 11, 2006, Pages 3015-3018

  Zeng, Fanxing ^a   Southerland, Jeanine A ^a   Voll, Ronald J ^a   Votaw, John R ^a   Williams, Larry ^a   Ciliax, Brian J ^a   Levey, Allan I ^a   Goodman, Mark M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid; Alzheimer's disease; Fluorine 18; PET imaging

Indexed keywords

6 (2' FLUOROETHYL) 2 (4' DIMETHYLAMINO)PHENYLIMIDAZO[1,2 A]PYRIDINE F 18; 6 (3' FLUOROPROPYL) 2 (4' DIMETHYLAMINO)PHENYLIMIDAZO[1,2 A]PYRIDINE F 18; AMYLOID BETA PROTEIN; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; FLUORINE; IMIDAZO(1,2 A)PYRIDINE; IMIDAZO(1,2-A)PYRIDINE; PYRIDINE DERIVATIVE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; ISOTOPE LABELING; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; MACACA; METABOLISM; SYNTHESIS;

ANIMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; FLUORINE RADIOISOTOPES; HUMANS; MACACA MULATTA; MOLECULAR STRUCTURE; PYRIDINES;

EID: 33646017368     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.02.055     Document Type: Article

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