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Volumn 6, Issue 20, 2008, Pages 3703-3713

Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: Structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies

(11) Ghosh, Arun K a Gemma, Sandra a Takayama, Jun a Baldridge, Abigail a Leshchenko Yashchuk, Sofiya a Miller, Heather B a Wang, Yuan Fang b Kovalevsky, Andrey Y b Koh, Yashiro c,d Weber, Irene T b Mitsuya, Hiroaki c,d,e

a PURDUE UNIVERSITY (United States)

b GEORGIA STATE UNIVERSITY (United States)

c KUMAMOTO UNIVERSITY (Japan)

d Department of Hematology and Infectious Diseases ^*

e NATIONAL CANCER INSTITUTE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATION; ESTERS; ETHERS;

ANTIVIRAL ACTIVITIES; BIOLOGICAL EVALUATION; CLINICAL ISOLATES; DIOXOLANE; HIGH AFFINITY; HIV-1 PROTEASE; HIV-1 PROTEASE INHIBITORS; STEREOCENTERS; X-RAY STRUCTURES; X-RAY STUDIES;

LIGANDS;

BICYCLO COMPOUND; LIGAND; P16 PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1; PROTEINASE; PROTEINASE INHIBITOR; URETHAN;

ARTICLE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYMOLOGY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MULTIDRUG RESISTANCE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BICYCLO COMPOUNDS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, VIRAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LIGANDS; URETHANE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 53549119919 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/b809178a Document Type: Article

Times cited : (18)

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