Microvessel count predicts metastasis and prognosis in patients with gastric cancer

Journal of Surgical Oncology

Volumn 65, Issue 4, 1997, Pages 232-236

  Araya, Munemitsu ^a   Terashima, Masanori ^a   Takagane, Akinori ^a   Abe, Kaoru ^a   Nishizuka, Satoshi ^a   Yonezawa, Hitoshi ^a   Irinoda, Takashi ^a   Nakaya, Tsutomu ^a   Saito, Kazuyoshi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Antifactor VIII related antigen antibody; Gastric cancer; Tumor angiogenesis

Indexed keywords

ADULT; AGED; ANGIOGENESIS; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; MICROVASCULATURE; PRIORITY JOURNAL; PROGNOSIS; STOMACH CANCER; TUMOR VASCULARIZATION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; FEMALE; HUMANS; LIVER NEOPLASMS; LYMPHATIC METASTASIS; MALE; MICE; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PERITONEAL NEOPLASMS; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 0030788880     PISSN: 00224790     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9098(199708)65:4<232::AID-JSO2>3.0.CO;2-6     Document Type: Article

References (17)

1. Folkman J: What is the evidence that tumors are angiogenesis dependent. J Natl Cancer Inst 1990;82:4-6.
2. Weidner N, Semple JP, Welch WR, et al.: Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N Engl J Med 1991;324:1-8.
3. Weidner N, Folkman J, Pozza F, et al.: Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinoma. J Natl Cancer Inst 1992;84:1875-1887.
4. Bosari S, Lee AK, DeLellis RA, et al.: Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 1992;23: 755-761.
5. Macchiarini P, Fontanini G, Hardin MJ, et al.: Relation of neovascularisation to metastasis of non-small-cell lung cancer. Lancet 1992;340:145-146.
6. Hollingsworth HC, Kohn EC, Steinberg SM, et al.: Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 1995; 147:33-41.
7. Frank RE, Saclarides TJ, Leurgans S, et al.: Tumor angiogenesis as a predictor of recurrence and survival in patients with node-negative colon cancer. Ann Surg 1995;222:695-699.
8. Weidner N, Carroll PR, Flax J, et al.: Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am J Pathol 1993;143:401-409.
9. Yoshino S, Kato M, Okada K: Prognostic significance of microvessel count in low stage renal cell carcinoma. Int J Urol 1995; 2:156-160.
10. Graham CH, Rivers J, Kerbel RS, et al.: Extent of vascularization as a prognostic indicator in thin (<0.76 mm) malignant melanomas. Am J Pathol 1994;145:510-514.
11. Gasparini G, Weidner N, Maluta S, et al.: Intratumoral microvessel density and p53 protein: correlation with metastasis in head-and-neck squamous-cell carcinoma. Int J Cancer 1993;55:739-744.
12. Maeda K, Chung YS, Takatsuka S, et al.: Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J Clin Oncol 1995; 13:477-481.
13. Tanigawa N, Amaya H, Matsumura M, et al.: Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinoma. Cancer Res 1996;56:2671-2676.
14. Nishi M, Omori Y, Miwa K (eds): "Japanese Classification of Gastric Carcinoma." Tokyo: Kanehara, 1995.
15. Nagy JA, Brown LF, Senger DR, et al.: Pathogenesis of tumor stroma generation: A critical role for leaky blood vessels and fibrin deposition. Biochim Biophys Acta 1989;948:305-326.
16. Gasparini G, Weidner N, Bevilacqua P, et al.: Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol 1994;12:454-466.
17. Folkman J: Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1995;1:27-31.