메뉴 건너뛰기




Volumn 597, Issue 1-3, 2008, Pages 1-5

BAFF-targeting therapy, a promising strategy for treating autoimmune diseases

Author keywords

Autoimmune disease; BAFF; Rituximab; Therapy

Indexed keywords

ATACICEPT; B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; BELIMUMAB; MONOCLONAL ANTIBODY; RITUXIMAB; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 53449084380     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.08.027     Document Type: Review
Times cited : (31)

References (53)
  • 1
    • 0942290441 scopus 로고    scopus 로고
    • Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells
    • Allman D., Srivastava B., and Lindsley R.C. Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells. Immunol. Rev. 197 (2004) 147-160
    • (2004) Immunol. Rev. , vol.197 , pp. 147-160
    • Allman, D.1    Srivastava, B.2    Lindsley, R.C.3
  • 2
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
    • Arkin M.R., and Wells J.A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3 (2004) 301-317
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 4
    • 33747837100 scopus 로고    scopus 로고
    • BAFF, APRIL and their receptors: structure, function and signaling
    • Bossen C., and Schneider P. BAFF, APRIL and their receptors: structure, function and signaling. Semin. Immunol. 18 (2006) 263-275
    • (2006) Semin. Immunol. , vol.18 , pp. 263-275
    • Bossen, C.1    Schneider, P.2
  • 5
    • 46849096714 scopus 로고    scopus 로고
    • B cell depletion therapy in systemic lupus erythematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response
    • Cambridge G., Isenberg D.A., Edwards J.C., Leandro M.J., Migone T.S., Teodorescu M., and Stohl W. B cell depletion therapy in systemic lupus erythematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response. Ann. Rheum. Dis. 67 (2008) 1011-1016
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1011-1016
    • Cambridge, G.1    Isenberg, D.A.2    Edwards, J.C.3    Leandro, M.J.4    Migone, T.S.5    Teodorescu, M.6    Stohl, W.7
  • 6
    • 0034972257 scopus 로고    scopus 로고
    • Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases
    • Cheema G.S., Roschke V., Hilbert D.M., and Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis Rheum. 44 (2001) 1313-1319
    • (2001) Arthritis Rheum. , vol.44 , pp. 1313-1319
    • Cheema, G.S.1    Roschke, V.2    Hilbert, D.M.3    Stohl, W.4
  • 7
    • 0036794398 scopus 로고    scopus 로고
    • BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells
    • Claudio E., Brown K., Park S., Wang H., and Siebenlist U. BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells. Nat. Immunol. 3 (2002) 958-965
    • (2002) Nat. Immunol. , vol.3 , pp. 958-965
    • Claudio, E.1    Brown, K.2    Park, S.3    Wang, H.4    Siebenlist, U.5
  • 8
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • REFLEX Trial Group
    • Cohen S.B., Emery P., Greenwald M.W., Dougados M., Furie R.A., Genovese M.C., Keystone E.C., Loveless J.E., Burmester G.R., Cravets M.W., Hessey E.W., Shaw T., Totoritis M.C., and REFLEX Trial Group. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54 (2006) 2793-2806
    • (2006) Arthritis Rheum. , vol.54 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3    Dougados, M.4    Furie, R.A.5    Genovese, M.C.6    Keystone, E.C.7    Loveless, J.E.8    Burmester, G.R.9    Cravets, M.W.10    Hessey, E.W.11    Shaw, T.12    Totoritis, M.C.13
  • 9
    • 0038142395 scopus 로고    scopus 로고
    • Macrophage- and dendritic cell-dependent regulation of human B cell proliferation requires the TNF family ligand BAFF
    • Craxton A., Magaletti D., Ryan E.J., and Clark E.A. Macrophage- and dendritic cell-dependent regulation of human B cell proliferation requires the TNF family ligand BAFF. Blood 101 (2003) 4464-4471
    • (2003) Blood , vol.101 , pp. 4464-4471
    • Craxton, A.1    Magaletti, D.2    Ryan, E.J.3    Clark, E.A.4
  • 10
    • 27944476444 scopus 로고    scopus 로고
    • BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway
    • Craxton A., Draves K.E., Gruppi A., and Clark E.A. BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. J. Exp. Med. 202 (2005) 1363-1374
    • (2005) J. Exp. Med. , vol.202 , pp. 1363-1374
    • Craxton, A.1    Draves, K.E.2    Gruppi, A.3    Clark, E.A.4
  • 11
    • 16844373775 scopus 로고    scopus 로고
    • Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands
    • Crowley J.E., Treml L.S., Stadanlick J.E., Carpenter E., and Cancro M.P. Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin. Immunol. 17 (2005) 193-199
    • (2005) Semin. Immunol. , vol.17 , pp. 193-199
    • Crowley, J.E.1    Treml, L.S.2    Stadanlick, J.E.3    Carpenter, E.4    Cancro, M.P.5
  • 12
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial
    • Dall Era M., Chakravarty E., Wallace D., Genovese M., Weisman M., Kavanaugh A., Kalunian K., Dhar P., Vincent E., Pena-Rossi C., and Wofsy D. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating trial. Arthritis Rheum. 56 (2007) 4142-4150
    • (2007) Arthritis Rheum. , vol.56 , pp. 4142-4150
    • Dall Era, M.1    Chakravarty, E.2    Wallace, D.3    Genovese, M.4    Weisman, M.5    Kavanaugh, A.6    Kalunian, K.7    Dhar, P.8    Vincent, E.9    Pena-Rossi, C.10    Wofsy, D.11
  • 13
    • 0035093233 scopus 로고    scopus 로고
    • Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes
    • Edwards J.C., and Cambridge G. Sustained improvement in rheumatoid arthritis following a protocol designed to deplete B lymphocytes. Rheumatology (Oxford). 40 (2001) 205-211
    • (2001) Rheumatology (Oxford). , vol.40 , pp. 205-211
    • Edwards, J.C.1    Cambridge, G.2
  • 16
    • 0141959215 scopus 로고    scopus 로고
    • Loss of the proapoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells
    • Enders A., Bouillet P., Puthalakath H., Xu Y., Tarlinton D.M., and Strasser A. Loss of the proapoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J. Exp. Med. 198 (2003) 1119-1126
    • (2003) J. Exp. Med. , vol.198 , pp. 1119-1126
    • Enders, A.1    Bouillet, P.2    Puthalakath, H.3    Xu, Y.4    Tarlinton, D.M.5    Strasser, A.6
  • 21
    • 0034254525 scopus 로고    scopus 로고
    • TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase
    • Hatzoglou A., Roussel J., Bourgeade M.F., Rogier E., Madry C., Inoue J., Devergne O., and Tsapis A. TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J. Immunol. 165 (2000) 1322-1330
    • (2000) J. Immunol. , vol.165 , pp. 1322-1330
    • Hatzoglou, A.1    Roussel, J.2    Bourgeade, M.F.3    Rogier, E.4    Madry, C.5    Inoue, J.6    Devergne, O.7    Tsapis, A.8
  • 23
    • 34447535192 scopus 로고    scopus 로고
    • Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion
    • Katsenelson N., Kanswal S., Puig M., Mostowski H., Verthelyi D., and Akkoyunlu M. Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion. Eur. J. Immunol. 37 (2007) 1785-1795
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1785-1795
    • Katsenelson, N.1    Kanswal, S.2    Puig, M.3    Mostowski, H.4    Verthelyi, D.5    Akkoyunlu, M.6
  • 25
    • 32444447885 scopus 로고    scopus 로고
    • Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    • Leandro M.J., Cambridge G., Ehrenstein M.R., and Edwards J.C. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum. 54 (2006) 613-620
    • (2006) Arthritis Rheum. , vol.54 , pp. 613-620
    • Leandro, M.J.1    Cambridge, G.2    Ehrenstein, M.R.3    Edwards, J.C.4
  • 27
    • 1842633887 scopus 로고    scopus 로고
    • Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF
    • Lesley R., Xu Y., Kalled S.L., Hess D.M., Schwab S.R., Shu H.B., and Cyster J.G. Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity 20 (2004) 441-453
    • (2004) Immunity , vol.20 , pp. 441-453
    • Lesley, R.1    Xu, Y.2    Kalled, S.L.3    Hess, D.M.4    Schwab, S.R.5    Shu, H.B.6    Cyster, J.G.7
  • 29
    • 33646198040 scopus 로고    scopus 로고
    • B cell immunobiology in disease: evolving concepts from the clinic
    • Martin F., and Chan A.C. B cell immunobiology in disease: evolving concepts from the clinic. Ann. Rev. Immunol. 24 (2006) 467-496
    • (2006) Ann. Rev. Immunol. , vol.24 , pp. 467-496
    • Martin, F.1    Chan, A.C.2
  • 30
    • 2442433618 scopus 로고    scopus 로고
    • Pathogenic roles of B cells in human autoimmunity; insights from the clinic
    • Martin F., and Chan A.C. Pathogenic roles of B cells in human autoimmunity; insights from the clinic. Immunity 20 (2004) 517-527
    • (2004) Immunity , vol.20 , pp. 517-527
    • Martin, F.1    Chan, A.C.2
  • 31
    • 4644240851 scopus 로고    scopus 로고
    • Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling
    • Mecklenbrouker I., Kalled S.L., Leitges M., Mackay F., and Tarakhovsky A. Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature 431 (2004) 456-461
    • (2004) Nature , vol.431 , pp. 456-461
    • Mecklenbrouker, I.1    Kalled, S.L.2    Leitges, M.3    Mackay, F.4    Tarakhovsky, A.5
  • 32
    • 38749090153 scopus 로고    scopus 로고
    • Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation
    • Meyer-Bahlburg A., Andrews S.F., Yu K.O., Porchelli S.A., and Rawlings D.J. Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. J. Exp. Med. 205 (2008) 155-168
    • (2008) J. Exp. Med. , vol.205 , pp. 155-168
    • Meyer-Bahlburg, A.1    Andrews, S.F.2    Yu, K.O.3    Porchelli, S.A.4    Rawlings, D.J.5
  • 33
    • 39549105619 scopus 로고    scopus 로고
    • B cell autonomous TLR signaling and autoimmunity
    • Meyer-Bahlburg A., and Rawlings D.J. B cell autonomous TLR signaling and autoimmunity. Autoimmunity 7 (2008) 313-316
    • (2008) Autoimmunity , vol.7 , pp. 313-316
    • Meyer-Bahlburg, A.1    Rawlings, D.J.2
  • 36
    • 4344597627 scopus 로고    scopus 로고
    • Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus
    • Ramanujam M., Wang X., Huang W., Schiffer L., Grimaldi C., Akkerman A., Diamond B., Madaio M.P., and Davidson A. Mechanism of action of transmembrane activator and calcium modulator ligand interactor-Ig in murine systemic lupus erythematosus. J. Immunol. 173 (2004) 3524-3534
    • (2004) J. Immunol. , vol.173 , pp. 3524-3534
    • Ramanujam, M.1    Wang, X.2    Huang, W.3    Schiffer, L.4    Grimaldi, C.5    Akkerman, A.6    Diamond, B.7    Madaio, M.P.8    Davidson, A.9
  • 39
    • 0034255259 scopus 로고    scopus 로고
    • B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1
    • Shu H.B., and Johnson H. B cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 9156-9161
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 9156-9161
    • Shu, H.B.1    Johnson, H.2
  • 40
    • 0032915632 scopus 로고    scopus 로고
    • TALL-1 is a novel member of the TNF family that is down-regulated by mitogens
    • Shu H.B., Hu W.H., and Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J. Leukoc. Biol. 65 (1999) 680-683
    • (1999) J. Leukoc. Biol. , vol.65 , pp. 680-683
    • Shu, H.B.1    Hu, W.H.2    Johnson, H.3
  • 41
    • 33745417203 scopus 로고    scopus 로고
    • A novel BLyS antagonist peptide designed based on the 3-D complex structure of BCMA and BLyS
    • Sun J., Feng J., Li Y., and Shen F. A novel BLyS antagonist peptide designed based on the 3-D complex structure of BCMA and BLyS. Biochem. Biophys. Res. Commun. 346 (2006) 1158-1162
    • (2006) Biochem. Biophys. Res. Commun. , vol.346 , pp. 1158-1162
    • Sun, J.1    Feng, J.2    Li, Y.3    Shen, F.4
  • 42
    • 33750209982 scopus 로고    scopus 로고
    • Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas
    • Sutherland A.P., Mackay F., and Mackay C.R. Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. Pharmacol. Ther. 112 (2006) 774-786
    • (2006) Pharmacol. Ther. , vol.112 , pp. 774-786
    • Sutherland, A.P.1    Mackay, F.2    Mackay, C.R.3
  • 44
  • 45
    • 2942518502 scopus 로고    scopus 로고
    • Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches
    • Thien M., Phan T.G., Gardam S., Amesbury M., Basten A., Mackay F., and Brink R. Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches. Immunity 20 (2004) 785-798
    • (2004) Immunity , vol.20 , pp. 785-798
    • Thien, M.1    Phan, T.G.2    Gardam, S.3    Amesbury, M.4    Basten, A.5    Mackay, F.6    Brink, R.7
  • 46
    • 24944538805 scopus 로고    scopus 로고
    • c-Myb is critical for B cell development and maintenance of follicular B cells
    • Thomas M.D., Kremer C.S., Ravichandran K.S., Rajewsky K., and Bender T.P. c-Myb is critical for B cell development and maintenance of follicular B cells. Immunity 23 (2005) 275-286
    • (2005) Immunity , vol.23 , pp. 275-286
    • Thomas, M.D.1    Kremer, C.S.2    Ravichandran, K.S.3    Rajewsky, K.4    Bender, T.P.5
  • 48
    • 2942525068 scopus 로고    scopus 로고
    • B cells, be gone-B-cell depletion in the treatment of rheumatoid arthritis
    • Tsokos G.C. B cells, be gone-B-cell depletion in the treatment of rheumatoid arthritis. N. Engl. J. Med. 350 (2004) 2546-2548
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2546-2548
    • Tsokos, G.C.1
  • 53
    • 0037114130 scopus 로고    scopus 로고
    • TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production
    • Xu L.G., and Shu H.B. TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J. Immunol. 169 (2002) 6883-6889
    • (2002) J. Immunol. , vol.169 , pp. 6883-6889
    • Xu, L.G.1    Shu, H.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.