Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines

Neuropharmacology

Volumn 47, Issue 5, 2004, Pages 706-713

  Graber, S ^a   Maiti, S ^a   Halpain, Shelley ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Actin filament; Cysteine protease; Cytoskeleton; Excitotoxicity; Glutamate receptor; Lyosome; Synapse

Indexed keywords

ALOXISTATIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CA 074 ME; CALPASTATIN; CALPEPTIN; CASPASE 8 INHIBITOR; CATHEPSIN B; CATHEPSIN L; CATHEPSIN L INHIBITOR 1; CYSTEINE PROTEINASE INHIBITOR; F ACTIN; LACTACYSTIN; LATRUNCULIN A; MARCKS PROTEIN; N METHYL DEXTRO ASPARTIC ACID; PEPTIDE HYDROLASE INHIBITOR; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CELL PROTECTION; CYTOSKELETON; CYTOTOXICITY; DENDRITIC SPINE; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SUBSTRATE; IMMUNOBLOTTING; IMMUNOREACTIVITY; INCUBATION TIME; LYSOSOME; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEINASE INHIBITION; STATISTICAL SIGNIFICANCE; STIMULATION; SYMPATHETIC BLOCKING;

ANIMALS; CATHEPSIN B; CELL SURVIVAL; CELLS, CULTURED; DENDRITES; FLOW CYTOMETRY; HIPPOCAMPUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MEMBRANE PROTEINS; N-METHYLASPARTATE; NEURONS; PROTEASE INHIBITORS; RATS;

EID: 5344224076     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.08.004     Document Type: Article

References (34)

1. Allison D.W., Gelfand V.I., Spector I., Craig A.M. Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors. J. Neurosci. 18:1998;2423-2436
2. Arbuzova A., Schmitz A.A., Vergeres G. Cross-talk unfolded: MARCKS proteins. Biochem. J. 362:2002;1-12
3. Betarbet R., Sherer T.B., Di Monte D.A., Greenamyre J.T. Mechanistic approaches to Parkinson's disease pathogenesis. Brain Pathol. 12:2002;499-510
4. Blanpied T.A., Ehlers M.D. Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease. Biol. Psychiatry. 55:2004;1121-1127
5. Chan S.L., Mattson M.P. Caspase and calpain substrates: roles in synaptic plasticity and cell death. J. Neurosci. Res. 58:1999;167-190
6. Cline H. Synaptic plasticity: importance of proteasome-mediated protein turnover. Curr. Biol. 13:2003;R514-R516
7. Felbor U., Kessler B., Mothes W., Goebel H.H., Ploegh H.L., Bronson R.T., Olsen B.R. Neuronal loss and brain atrophy in mice lacking cathepsins B and L. Proc. Natl. Acad. Sci. USA. 99:2002;7883-7888
8. Goslin K., Asmussen H., Banker G.A. Rat hippocampal neurons in low-density culture. Banker G.A., Goslin K. Culturing Nerve Cells. 1998;339-370 The MIT Press, Cambridge, MA
9. Halpain, S., Spencer, K., Graber, S., in press. Dynamics and pathology of dendritic spines. Prog. Brain Res.
10. Halpain S., Hipolito A., Saffer L. Regulation of F-actin stability in dendritic spines by glutamate receptors and calcineurin. J. Neurosci. 18:1998;23
11. Hartwig J.H., Thelen M., Rosen A., Janmey P.A., Nairn A.C., Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature. 356:1992;618-622
12. Hering H., Sheng M. Dendritic spines: structure, dynamics and regulation. Nat. Rev. Neurosci. 2:2001;880-888
13. Keppler D., Sameni M., Moin K., Mikkelsen T., Diglio C.A., Sloane B.F. Tumor progression and angiogenesis: cathepsin B & Co. Biochem. Cell Biol. 74:1996;799-810
14. Laux T., Fukami K., Thelen M., Golub T., Frey D., Caroni P. GAP43, MARCKS and CAP23 modulate PI(4,5)P(2) at plasmalemmal rafts, and regulate cell cortex actin dynamics through a common mechanism. J. Cell Biol. 149:2000;1455-1472
15. Linke M., Herzog V., Brix K. Trafficking of lysosomal cathepsin B-green fluorescent protein to the surface of thyroid epithelial cells involves the endosomal/lysosomal compartment. J. Cell Sci. 115:2002;4877-4889
16. Matus A. Actin-based plasticity in dendritic spines. Science. 290:2000;754-758
17. McLaughlin S., Aderem A. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem. Sci. 20:1995;272-276
18. Nimchinsky E.A., Sabatini B.L., Svoboda K. Structure and function of dendritic spines. Annu. Rev. Physiol. 64:2002;313-353
19. Nixon R.A. A "protease activation cascade" in the pathogenesis of Alzheimer's disease. Ann. N. Y. Acad. Sci. 924:2000;117-131
20. Ouimet C.C., Wang J.K., Walaas S.I., Albert K.A., Greengard P. Localization of the MARCKS (87 kDa) protein, a major specific substrate for protein kinase C, in rat brain. J. Neurosci. 10:1990;1683-1698
21. Ray S.K., Dixon C.E., Banik N.L. Molecular mechanisms in the pathogenesis of traumatic brain injury. Histol. Histopathol. 17:2002;1137-1152
22. Reinheckel T., Deussing J., Roth W., Peters C. Towards specific functions of lysosomal cysteine peptidases: phenotypes of mice deficient for cathepsin B or cathepsin L. Biol. Chem. 382:2001;735-741
23. Saku T., Sakai H., Shibata Y., Kato Y., Yamamoto K. An immunocytochemical study on distinct intracellular localization of cathepsin E and cathepsin D in human gastric cells and various rat cells. J. Biochem. (Tokyo). 110:1991;956-964
24. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science. 298:2002;789-791
25. Shiraishi Y., Mizutani A., Mikoshiba K., Furuichi T. Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons. Mol. Cell. Neurosci. 22:2003;188-201
26. Spizz G., Blackshear P.J. Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme. J. Biol. Chem. 272:1997;23833-23842
27. Stumpo D.J., Bock C.B., Tuttle J.S., Blackshear P.J. MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc. Natl. Acad. Sci. USA. 92:1995;944-948
28. Swann J.W., Al Noori S., Jiang M., Lee C.L. Spine loss and other dendritic abnormalities in epilepsy. Hippocampus. 10:2000;617-625
29. Tsukuba T., Hori H., Azuma T., Takahashi T., Taggart R.T., Akamine A., Ezaki M., Nakanishi H., Sakai H., Yamamoto K. Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells. J. Biol. Chem. 268:1993;7276-7282
30. Wang J., Arbuzova A., Hangyas-Mihalyne G., McLaughlin S. The effector domain of myristoylated alanine-rich C kinase substrate binds strongly to phosphatidylinositol 4,5-bisphosphate. J. Biol. Chem. 276:2001;5012-5019
31. Wohnsland F., Schmitz A.A., Steinmetz M.O., Aebi U., Vergeres G. Interaction between actin and the effector peptide of MARCKS-related protein. Identification of functional amino acid segments. J. Biol. Chem. 275:2000;20873-20879
32. Yamashima T. Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog. Neurobiol. 62:2000;273-295
33. Yin H.L., Janmey P.A. Phosphoinositide regulation of the actin cytoskeleton. Annu. Rev. Physiol. 65:2003;761-789
34. Zhang W., Benson D.L. Stages of synapse development defined by dependence on f-actin. J. Neurosci. 21:2001;5169-5181