Involvement of median raphe nucleus 5-HT1A receptors in the regulation of generalized anxiety-related defensive behaviours in rats

Neuroscience Letters

Volumn 445, Issue 3, 2008, Pages 204-208

  Vicente, Maria Adrielle ^a   Zangrossi Jr , Hélio ^b   dos Santos, Lucinéia ^a   de Macedo, Carlos Eduardo ^a   Andrade, Telma Gonçalves C S ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

8 OH DPAT and WAY 100635; Generalized anxiety; Median raphe nucleus; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DRUG EFFECT; MALE; MAZE TEST; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RISK ASSESSMENT; TASK PERFORMANCE;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; ANXIETY; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITION (PSYCHOLOGY); MALE; MAZE LEARNING; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, WISTAR; REACTION TIME; RECEPTOR, SEROTONIN, 5-HT1A; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 53249155838     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.09.003     Document Type: Article

References (41)

1. Adell A., Carceller A., and Artigas F. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 60 (1993) 1673-1681
2. Aghajanian G.K. Chemical-feedback regulation of serotonin-containing neurons in brain. Ann. N. Y. Acad. Sci. 193 (1972) 86-94
3. Andrade T.G., and Graeff F.G. Effect of electrolytic and neurotoxic lesions of the median raphe nucleus on anxiety and stress. Pharmacol. Biochem. Behav. 70 (2001) 1-14
4. Andrade T.G., Macedo C.E., Zangrossi Jr. H., and Graeff F.G. Anxiolytic-like effects of median raphe nucleus lesion in the elevated T-maze. Behav. Brain Res. 153 (2004) 55-60
5. Avanzi V., and Brandao M.L. Activation of somatodendritic 5-HT(1A) autoreceptors in the median raphe nucleus disrupts the contextual conditioning in rats. Behav. Brain Res. 126 (2001) 175-184
6. Azmitia E.C., and Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179 (1978) 641-667
7. Blanchard D.C., and Blanchard R.J. Ethoexperimental approaches to the biology of emotion. Annu. Rev. Psychol. 39 (1988) 43-68
8. Blanchard R.J., Yudko E.B., Rodgers R.J., and Blanchard D.C. Defense system psychopharmacology: an ethological approach to the pharmacology of fear and anxiety. Behav. Brain Res. 58 (1993) 155-165
9. Canto-de-Souza A., Nunes-de-Souza R.L., and Rodgers R.J. Anxiolytic-like effect of Way-100635 microinfusions into the median (but not dorsal) raphe nucleus in mice exposed to the plus-maze: influence of prior test experience. Brain Res. 928 (2002) 50-59
10. Carli M., and Samanin R. Potential anxiolytic properties of 8-hydroxy-2-(di-n-propylamino)tetralin, a selective serotonin 1A receptor agonist. Psychopharmacology (Berl.) 94 (1988) 84-91
11. De Almeida R.M., Giovenardi M., Charchat H., and Lucion A.B. 8-OH-DPAT in the median raphe nucleus decreases while in the medial septal area it may increase anxiety in female rats. Neurosci. Biobehav. Rev. 23 (1998) 259-264
12. Deakin J.F.W., and Graeff F.G. 5-HT and mechanisms of defence. J. Psychopharmacol. 5 (1991) 305-315
13. Dos Santos L., de Andrade T.G., and Zangrossi Jr. H. Serotonergic neurons in the median raphe nucleus regulate inhibitory avoidance but not escape behavior in the rat elevated T-maze test of anxiety. Psychopharmacology (Berl.) 179 (2005) 733-741
14. Dos Santos L., de Andrade T.G., and Zangrossi Jr. H. 5-HT1A receptors in the dorsal hippocampus mediate the anxiogenic effect induced by the stimulation of 5-HT neurons in the median raphe nucleus. Eur. Neuropsychopharmacol. 18 (2008) 286-294
15. Dudley T.E., Dinardo L.A., and Glass J.D. In vivo assessment of the midbrain raphe nuclear regulation of serotonin release in the hamster suprachiasmatic nucleus. J. Neurophysiol. 81 (1999) 1469-1477
16. Duncan M.J., Short J., and Wheeler D.L. Comparison of the effects of aging on 5-HT7 and 5-HT1A receptors in discrete regions of the circadian timing system in hamsters. Brain Res. 829 (1999) 39-45
17. File S.E., Gonzalez L.E., and Andrews N. Comparative study of pre- and post-synaptic 5-HT1A receptor modulation of anxiety in two ethological animal tests. J. Neurosci. 16 (1996) 4810-4815
18. Fornal C.A., Metzler C.W., Gallegos R.A., Veasey S.C., McCreary A.C., and Jacobs B.L. WAY-100635, a potent and selective 5-hydroxytryptamine1A antagonist, increases serotonergic neuronal activity in behaving cats: comparison with (S)-WAY-100135. J. Pharmacol. Exp. Ther. 278 (1996) 752-762
19. Graeff F.G. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 28 (2004) 239-259
20. Graeff F.G., Netto C.F., and Zangrossi Jr. H. The elevated T-maze as an experimental model of anxiety. Neurosci. Biobehav. Rev. 23 (1998) 237-246
21. Graeff F.G., and Silveira Filho N.G. Behavioral inhibition induced by electrical stimulation of the median raphe nucleus of the rat. Physiol. Behav. 21 (1978) 477-484
22. Graeff F.G., and Zangrossi Jr. H. Animal models of anxiety. In: D'Haenen H., den Boer J.A., and Willner P. (Eds). Biological Psychiatric (2002), Wiley, Chichester 879-893
23. Gray J.A., and McNaughton N. The Neuropsychology of Anxiety (2000), Oxford University Press
24. Haddjeri N., Faure C., Lucas G., Mnie-Filali O., Chouvet G., Astier B., Renaud B., Blier P., and Debonnel G. In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system. Int. J. Neuropsychopharmacol. 7 (2004) 391-399
25. Handley S.L., McBlane J.W., Critchley M.A., and Njung'e K. Multiple serotonin mechanisms in animal models of anxiety: environmental, emotional and cognitive factors. Behav. Brain Res. 58 (1993) 203-210
26. Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 54 (1996) 21-30
27. Jacobs B.L., and Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72 (1992) 165-229
28. Judge S.J., and Gartside S.E. Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential alpha1-adrenoceptor and 5-HT1A receptor modulation. Neurochem. Int. 42 (2006) 100-107
29. Kalsner S. The question of feedback at the somadendritic region and antidepressant drug action. Brain Res. Bull. 52 (2000) 467-473
30. Martel J.C., Leduc N., Ormiere A.M., Faucillon V., Danty N., Culie C., Cussac D., and Newman-Tancredi A. WAY-100635 has high selectivity for serotonin 5-HT91A) versus dopamine D(4) receptors. Eur. J. Pharmacol. 574 (2007) 15-19
31. Martin L.P., Jackson D.M., Wallsten C., and Waszczac B.L. Electophysiological comparison of 5-hydroxytryptamine1A receptor antagonists on dorsal raphe cell firing. J. Pharmacol. Exp. Ther. 288 (1999) 820-826
32. Martin-Cora F.J., and Pazos A. Autoradiographic distribution of 5-HT7 receptors in the human brain using [3H]mesulergine: comparison to other mammalian species. Br. J. Pharmacol. 141 (2004) 92-104
33. McQuade R., and Sharp T. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J. Neurochem. 69 (1997) 791-796
34. Mundey M.K., Fletcher A., and Marsden C.A. Effects of 8-OHDPAT and 5-HT1A antagonists WAY100135 and WAY100635, on guinea-pig behaviour and dorsal raphe 5-HT neurone firing. Br. J. Pharmacol. 117 (1996) 750-756
35. Pinheiro S.H., Zangrossi Jr. H., Del-Ben C.M., and Graeff F.G. Elevated mazes as animal models of anxiety: effects of serotonergic agents. An. Acad. Bras. Cienc. 79 (2007) 71-85
36. Primus R.J., Thurkauf A., Xu J., Yevich E., McInerney S., Shaw K., Tallman J.F., and Gallagher D.W. Localization and characterization of dopamine D4 binding sites in rats and human brain by use of the novel, D4 receptor-selective ligand [3H] NGD. J. Pharmacol. Exp. Ther. 282 (1997) 1020-1027
37. Sena L.M., Bueno C., Pobbe R.H., de Andrade T.G.C.S., Zangrossi Jr. H., and Viana M.B. The dorsal raphe nucleus exerts opposed control on generalized anxiety and panic-related defensive responses in rats. Behav. Brain Res. 142 (2003) 125-133
38. Srebro B., and Lorens S.A. Behavioral effects of selective midbrain raphe lesions in the rat. Brain Res. 89 (1975) 303-325
39. Thomas D.R., Gittins S.A., Collin L.L., Middlemiss D.N., Riley G., Hagan J., Gloger I., Ellis C.E., Forbes I.T., and Brown A.M. Functional characterisation of the human cloned 5-HT7 receptor (long form); antagonist profile of SB-258719. Br. J. Pharmacol. 124 (1998) 1300-1306
40. Vertes R.P. A PHA-L analysis of ascending projections of the dorsal raphe nucleus in the rat. J. Comp. Neurol. 313 (1991) 643-668
41. Vertes R.P., Fortin W.J., and Crane A.M. Projections of the median raphe nucleus in the rat. J. Comp. Neurol. 407 (1999) 555-582