Hypoxia-inducible adrenomedullin accelerates hepatocellular carcinoma cell growth

Cancer Letters

Volumn 271, Issue 2, 2008, Pages 314-322

  Park, Su Cheol ^a,b   Yoon, Jung Hwan ^c   Lee, Jeong Hoon ^c   Yu, Su Jong ^c   Myung, Sun Jung ^c   Kim, Won ^c   Gwak, Geum Youn ^d   Lee, Sung Hee ^c   Lee, Soo Mi ^c   Jang, Ja June ^c   Suh, Kyung Suk ^c   Lee, Hyo Suk ^c  

^a Korea Cancer Center Hospital   (South Korea)

^b Kangwon National University College of Medicine   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Adrenomedullin; Akt; Hepatocellular carcinoma; Hypoxia; N cadherin

Indexed keywords

ADRENOMEDULLIN; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B;

ADULT; ARTICLE; CELL GROWTH; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADRENOMEDULLIN; ADULT; ANOXIA; BASE SEQUENCE; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CELL LINE; DNA PRIMERS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 53249153472     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.06.019     Document Type: Article

References (50)

1. Poynard T., Aubert A., Lazizi Y., Bedossa P., Hamelin B., Terris B., et al. Independent risk factors for hepatocellular carcinoma in French drinkers. Hepatology 13 (1991) 896-901
2. Tsukuma H., Hiyama T., Tanaka S., Nakao M., Yabuuchi T., Kitamura T., et al. Risk factors for hepatocellular carcinoma among patients with chronic liver disease. N. Engl. J. Med. 328 (1993) 1797-1801
3. Seitz H.K., and Stickel F. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress. Biol. Chem. 387 (2006) 349-360
4. Yu M.C., and Yuan J.M. Environmental factors and risk for hepatocellular carcinoma. Gastroenterology 127 (2004) S72-S78
5. Wogan G.N. Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res. 52 (1992) 2114s-2118s
6. El-Serag H.B. Hepatocellular carcinoma: an epidemiologic view. J. Clin. Gastroenterol. 35 (2002) S72-S78
7. Fattovich G., Stroffolini T., Zagni I., and Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 127 (2004) S35-S50
8. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J. Biol. Chem. 275 (2000) 2247-2250
9. Geerts A. History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin. Liver Dis. 21 (2001) 311-335
10. Kalluri R., and Sukhatme V.P. Fibrosis and angiogenesis. Curr. Opin. Nephrol. Hypertens. 9 (2000) 413-418
11. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
12. Tanaka S., and Arii S. Current status and perspective of antiangiogenic therapy for cancer: hepatocellular carcinoma. Int. J. Clin. Oncol. 11 (2006) 82-89
13. Kim K.R., Moon H.E., and Kim K.W. Hypoxia-induced angiogenesis in human hepatocellular carcinoma. J. Mol. Med. 80 (2002) 703-714
14. Gwak G.Y., Yoon J.H., Kim K.M., Lee H.S., Chung J.W., and Gores G.J. Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression. J. Hepatol. 42 (2005) 358-364
15. Hinson J.P., Kapas S., and Smith D.M. Adrenomedullin, a multifunctional regulatory peptide. Endocr. Rev. 21 (2000) 138-167
16. Nikitenko L.L., Smith D.M., Bicknell R., and Rees M.C. Transcriptional regulation of the CRLR gene in human microvascular endothelial cells by hypoxia. FASEB J. 17 (2003) 1499-1501
17. Nikitenko L.L., Fox S.B., Kehoe S., Rees M.C., and Bicknell R. Adrenomedullin and tumour angiogenesis. Br. J. Cancer 94 (2006) 1-7
18. Zudaire E., Martinez A., and Cuttitta F. Adrenomedullin and cancer. Regul. Pept. 112 (2003) 175-183
19. Fujita Y., Mimata H., Nasu N., Nomura T., Nomura Y., and Nakagawa M. Involvement of adrenomedullin induced by hypoxia in angiogenesis in human renal cell carcinoma. Int. J. Urol. 9 (2002) 285-295
20. Keleg S., Kayed H., Jiang X., Penzel R., Giese T., Buchler M.W., et al. Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion. Int. J. Cancer 121 (2007) 21-32
21. Görbig M.N., Ginès P., Bataller R., Nicolás J.M., Garcia-Ramallo E., Cejudo P., et al. Human hepatic stellate cells secrete adrenomedullin: potential autocrine factor in the regulation of cell contractility. J. Hepatol. 34 (2001) 222-229
22. 4-induced rat liver cirrhosis. Regul. Pept. 135 (2006) 69-77
23. Higuchi H., Bronk S.F., Takikawa Y., Werneburg N., Takimoto R., El-Deiry W., et al. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J. Biol. Chem. 276 (2001) 38610-38618
24. Nakabayashi H., Taketa K., Miyano K., Yamane T., and Sato J. Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res. 42 (1982) 3858-3863
25. Park J.G., Lee J.H., Kang M.S., Park K.J., Jeon Y.M., Lee H.J., et al. Characterization of cell lines established from human hepatocellular carcinoma. Int. J. Cancer 62 (1995) 276-282
26. Gwak G.Y., Yoon J.H., Yu S.J., Park S.C., Jang J.J., Lee K.B., et al. Anti-apoptotic N-cadherin signaling and its prognostic implication in human hepatocellular carcinomas. Oncol. Rep. 15 (2006) 1117-1123
27. Shirabe K., Kanematsu T., Matsumata T., Adachi E., Akazawa K., and Sugimachi K. Factors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses. Hepatology 14 (1991) 802-805
28. Nagasue N., Uchida M., Makino Y., Takemoto Y., Yamanoi A., Hayashi T., et al. Incidence and factors associated with intrahepatic recurrence following resection of hepatocellular carcinoma. Gastroenterology 105 (1993) 488-494
29. Okada S., Shimada K., Yamamoto J., Takayama T., Kosuge T., Yamasaki S., et al. Predictive factors for postoperative recurrence of hepatocellular carcinoma. Gastroenterology 106 (1994) 1618-1624
30. Satoh F., Takahashi K., Murakami O., Totsune K., Sone M., Ohneda M., et al. Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. J. Clin. Endocrinol. Metab. 80 (1995) 1750-1752
31. Zimmermann U., Fischer J.A., Frei K., Fischer A.H., Reinscheid R.K., and Muff R. Identification of adrenomedullin receptors in cultured rat astrocytes and in neuroblastboma × glioma hybrid cells (NG108-15). Brain Res. 724 (1996) 238-245
32. Martinez A., Miller M.J., Unsworth E.J., Siegfried J.M., and Cuttitta F. Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology 136 (1995) 4099-4105
33. Miller M.J., Martinez A., Unsworth E.J., Thiele C.J., Moody T.W., Elsasser T., et al. Adrenomedullin expression in human tumor cell lines. its potential role as an autocrine growth factor. J. Biol. Chem. 271 (1996) 23345-23351
34. Ramachandran V., Arumugam T., Hwang R.F., Greenson J.K., Simeone D.M., and Logsdon C.D. Adrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR. Cancer Res. 67 (2007) 2666-2675
35. Iwase T., Nagaya N., Fujii T., Itoh T., Ishibashi-Ueda H., Yamagishi M., et al. Adrenomedullin enhances angiogenic potency of bone marrow transplantation in a rat model of hindlimb ischemia. Circulation 111 (2005) 356-362
36. Kim W., Moon S.O., Sung M.J., Kim S.H., Lee S., So J.N., et al. Angiogenic role of adrenomedullin through activation of Akt, mitogen-activated protein kinase, and focal adhesion kinase in endothelial cells. FASEB J. 17 (2003) 1937-1939
37. Fritz-Six K.L., Dunworth W.P., Li M., and Caron K.M. Adrenomedullin signaling is necessary for murine lymphatic vascular development. J. Clin. Invest. 118 (2008) 40-50
38. Mouta Carreira C., Nasser S.M., di Tomaso E., Pandera T.P., Boucher Y., Tomarev S.I., et al. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoid and down-regulation in human liver cancer and cirrhosis. Cancer Res. 61 (2001) 8079-8084
39. Hockel M., and Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93 (2001) 266-276
40. Semenza G.L. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88 (2000) 1474-1480
41. Maxwell P.H., Pugh C.W., and Ratcliffe P.J. Activation of the HIF pathway in cancer. Curr. Opin. Genet. Dev. 11 (2001) 293-299
42. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15 (1999) 551-578
43. Wang X., Yue T.L., Barone F.C., White R.F., Clark R.K., Willette R.N., et al. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc. Natl. Acad. Sci. USA 92 (1995) 11480-11484
44. Kitamuro T., Takahashi K., Nakayama M., Murakami O., Hida W., Shirato K., et al. Induction of adrenomedullin during hypoxia in cultured human glioblastoma cells. J. Neurochem. 75 (2000) 1826-1833
45. Ladoux A., and Frelin C. Coordinated up-regulation by hypoxia of adrenomedullin and one of its putative receptors (RDC-1) in cells of the rat blood-brain barrier. J. Biol. Chem. 275 (2000) 39914-39919
46. Serrano J., Alonso D., Encinas J.M., Lopez J.C., Fernandez A.P., Castro-Blanco S., et al. Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat. Neuroscience 109 (2002) 717-731
47. Garayoa M., Martinez A., Lee S., Pio R., An W.G., Neckers L., et al. Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol. Endocrinol. 14 (2000) 848-862
48. Nakayama M., Takahashi K., Murakami O., Shirato K., and Shibahara S. Induction of adrenomedullin by hypoxia and cobalt chloride in human colorectal carcinoma cells. Biochem. Biophys. Res. Commun. 243 (1998) 514-517
49. Nieman M.T., Prudoff R.S., Johnson K.R., and Wheelock M.J. N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J. Cell Biol. 147 (1999) 631-644
50. Hazan R.B., Phillips G.R., Qiao R.F., Norton L., and Aaronson S.A. Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J. Cell Biol. 148 (2000) 779-790