Palladium-catalysed amination of 2-acyl-1-alkyl-5-bromopyrroles

Tetrahedron Letters

Volumn 45, Issue 4, 2004, Pages 769-772

  Castellote, Isabel ^a   Vaquero, Juan J ^a   Alvarez Builla, Julio ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

2 Halopyrroles; Amination; Catalysed; Functionalised; Palladium

Indexed keywords

AMINE; LIGAND; PALLADIUM; PYRROLE DERIVATIVE;

AMINATION; ARTICLE; CATALYSIS; CHEMICAL BOND; HIGH TEMPERATURE; MOLECULAR INTERACTION; QUANTUM YIELD; SUBSTITUTION REACTION;

EID: 0348048825     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.11.029     Document Type: Article

References (21)

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16. This study was carried out before Hartwig's work in Ref. 11 was published.
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18. Both racemic and R-(+)-BINAP give the same yields in the amination reaction.
19. 2 (10 mL), filtered over Celite and concentrated. Column chromatography of the residue on silica gel using EtOAc as eluent gave pure compounds 4.
20. 2; C, 56.75; H, 4.03; N, 10.18. Found: C, 56.49; H, 4.23; N, 10.11.
21. 2/MeOH (8:2) saturated with ammonia as eluent.