Synthesis and biological evaluation of immunosuppressive agent DZ2002 and its stereoisomers

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 20, 2008, Pages 9212-9216

  Zhang, Yang Ming ^a,b   Ding, Yu ^b   Tang, Wei ^b   Luo, Wei ^b   Gu, Min ^b   Lu, Wei ^a   Tang, Jie ^a   Zuo, Jian Ping ^b   Nan, Fa Jun ^b  

^a EAST CHINA NORMAL UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

DZ2002; Immunosuppressive potency; S Adenosyl l homocysteine hydrolase; Stereoisomers; Synthesis

Indexed keywords

4 (6 AMINOPURIN 9 YL) 2 HYDROXYBUTYRIC ACID METHYL ESTER; ADENOSYLHOMOCYSTEINASE; DZ 2002; IMMUNOSUPPRESSIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IMMUNOMODULATION; IMMUNOSUPPRESSIVE TREATMENT; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; REACTION ANALYSIS; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ADENINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; BUTYRIC ACIDS; CELL PROLIFERATION; CELLS, CULTURED; ENZYME INHIBITORS; IMMUNOSUPPRESSIVE AGENTS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RABBITS; STEREOISOMERISM;

EID: 53249089996     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.017     Document Type: Article

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