S-adenosyl-L-homocysteine hydrolase inhibitor mediates immunosuppressive effects in vivo: Suppression of delayed type hypersensitivity ear swelling and peptidoglycan polysaccharide-induced arthritis

Journal of Pharmacology and Experimental Therapeutics

Volumn 296, Issue 1, 2001, Pages 106-112

  Saso, Yoshihisa ^a,b   Conner, Elaine M ^a   Teegarden, Bradley R ^a   Yuan, Chong Sheng ^a,c  

^a Tanabe Research Laboratories   (United States)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^c Diazyme Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; 9 (2',3' DIHYDROXYCYCLOPENTANYL)ADENINE; ADENOSYLHOMOCYSTEINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; CONCANAVALIN A; INTERLEUKIN 1; PEPTIDOGLYCAN POLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DELAYED HYPERSENSITIVITY; DOSE RESPONSE; DRUG EFFICACY; DRUG INHIBITION; ENZYME INHIBITION; FEMALE; HISTOPATHOLOGY; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; OTITIS; PRIORITY JOURNAL; RAT; SPLEEN; T LYMPHOCYTE;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; DINITROFLUOROBENZENE; EAR; EDEMA; ENZYME INHIBITORS; FEMALE; HYDROLASES; HYPERSENSITIVITY, DELAYED; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-1; JOINTS; MICE; MICE, INBRED BALB C; PEPTIDOGLYCAN; POLYSACCHARIDES; RATS; RATS, INBRED LEW; SPLEEN; T-LYMPHOCYTES; THYMIDINE;

EID: 0035196908     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. 5′-terminal cap structure in eucaryotic messenger ribonucleic acids
2. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhoraocysteine hydrolase in neuroblastoma N2a cells
3. Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells
4. Purine deoxynucleosides and adenosine dialdehyde decrease 5-amino-4-imidazolecarboxamide(Z-base)-dependent purine nucleotide synthesis in cultured T and B lymphoblasts
5. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
6. T cell regulation and T cell clones in reaction to synovial inflammation
7. The role of S-adensylhomcysteine in the biological utilization of S-adensylmethionine
8. The centrality of S-adenosylhomocysteinase in the regulation of the biological utilization of S-adenosylhpmocysteine
9. The formation of S-adenosylhomocysteine in enzymatic transmethylation reactions
10. S-adenosylmethionine and methylation
11. Arthritis in rats after systemic injection of streptococcal cells or cell walls
12. Stimulation of the phosphatidylinositol pathway can induce T-cell activation
13. Cytokine and nitric oxide production in the acute phase of bacterial cell wall-induced arthritis
14. Measurements of S-adenosylmethionine and L-homocysteine metabolism in cultured human lymphoid cells
15. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
16. T lymphocytes in collagen II-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T-cell lines and clones
17. In vivo treatment of rats with monoclonal anti-T-cell antibodies. Immunohistochemical and functional analysis in normal rats and in experimental allergic neuritis
18. Short note. Redox state changes in density-dependent regulation of proliferation
19. Characteristics of adrenergic binding sites associated with routine lymphocytes isolated from spleen
20. Adenosine dialdehyde: A potent inhibitor of vaccinia virus mutation in mouse L929 cells
21. Mechanism of the cytostatic activity of 3-deazaaristeromycin, an inhibitor of adenosylhomocysteine hydrolase
22. The redox status of aminothiols as a clue to homocysteine-induced vascular damage?
23. Effects of an S-adenosyl-L-homocysteine hydrolase inhibiter on murine macrophage activation and function
24. Lactobacillus casei-induced polyarthritis in Lewis rats: Histepathological scoring system for evaluation of anti-rheumatic drugs
25. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
26. Inhibition of phosphoinositide metabolism in human polymorphonuclear leukocytes by S-adensylhomcysteine
27. Adenosine dialdehyde and neplanocin A: Potent inhibitors of S-adenosylhomocysteine hydrolase in neuroblastoma N2a cells
28. In vivo modulation of murine collagen induced arthritis
29. Inhibitors of reactive oxygen intermediates suppress bacterial cell wall-induced arthritis
30. Homocysteine redox receptor and regulation of extracellular matrix components in vascular cells
31. Disposition of endogenous S-adenosylhomocysteine and homocysteine following exposure to nucleoside analogs and methotrexate
32. Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment
33. Thymus-dependent and -independent regulation of Ia antigen expression in situ by cells in the synovium of rats with streptococcal cell wall-induced arthritis
34. 1 cells
35. Immunomodulation by inhibitor of S-adenosyl-L-homecysteine hydrolase: Inhibition of in vitro and in vivo allogenic responses
36. Selective inhibition of T cell activation by an inhibiter of S-adenosyl-L-homocysteine hydrolase
37. Immunosuppression mediated by an inhibitor of S-anenosyl-L-homocysteine hydrolase. Prevention and treatment of collagen-induced arthritis
38. Inhibition by cyclosporin A of streptococcal cell wall-induced arthritis and hepatic granulomas in rats
39. Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (E)-5′6′-didehydro-6′-deoxy-6′-halohomoadenosines
40. Design and synthesis of S-adenosylhomocysteine hydrolase inhibitors as broad-spectrum antiviral agents
41. Recent advances in S-adenosyl-L-homocysteine hydrolase inhibitors and their potential clinical applications
42. Mechanism of inactivation of S-adenosylhomocysteine hydrolase by (Z)-4′,5′-didehydro-5′-fluoroadenosine