Distribution of mucins and antimicrobial substances lysozyme and lactoferrin in the laryngeal subglottic region

Journal of Anatomy

Volumn 213, Issue 4, 2008, Pages 473-481

  Kutta, Hannes ^a,b   Willer, Andreas ^c   Steven, Philipp ^a,d   Bräuer, Lars ^d   Tsokos, Michael ^b,e   Paulsen, Friedrich ^a,c  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^d UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Antimicrobial defence; Lactoferrin; Larynx; Lysozyme; Mucin; Subglottic region

Indexed keywords

GLYCOPROTEIN; LACTOFERRIN; LYSOZYME; MUCIN; MUCIN 1; MUCIN 16; MUCIN 5AC; MUCIN 5B; MUCIN 7; MUCIN 8; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANTIBODY DETECTION; ARTICLE; CELLULAR DISTRIBUTION; CHILD; COLUMNAR EPITHELIUM; CONTROLLED STUDY; FEMALE; HOST RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; LARYNX; LARYNX CARCINOMA; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; VOCALIZATION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIBIOSIS; CHILD; CHILD, PRESCHOOL; FEMALE; GOBLET CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; LACTOFERRIN; LARYNGEAL MUCOSA; MALE; MIDDLE AGED; MUCINS; MURAMIDASE; YOUNG ADULT;

EID: 53149136247     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2008.00960.x     Document Type: Article

References (54)

1. Ali MS, Pearson JB (2007) Upper airway mucin gene expression: A review. Laryngoscope 117, 932-938.
2. Awaya H, Takeshima Y, Yamasaki M, Inai K (2004) Expression of MUC1, MUC2, MUC5AC, and MUC6 in atypical adenomatous hyperplasia, bronchioloalveolar carcinoma, adenocarcinoma with mixed subtypes, and mucinous bronchioloalveolar carcinoma of the lung. Am J Clin Pathol May 121 (5), 644-653.
3. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N (1999) Am J Respir Crit Care Med 160, S44-S48.
4. Bast RC Jr, Feeney M, Lazarus H, Nadler LM, Colvin RB, Knapp RC (1981) Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68, 1331-1337.
5. Berke GS, Gerratt BR (1993) Laryngeal biomechanics: An overview of mucosal wave mechanics. J Voice Jun 7 (2), 123-128.
6. Bernacki SH, Nelson AL, Abdullah L, et al. (1999) Mucin gene expression during differentiation of human airway epithelia in vitro. Muc4 and muc5b are strongly induced. Am J Respir Cell Mol Biol 20, 595-604.
7. Biesbrock AR, Bobek LA, Levine MJ (1997) MUC7 gene expression and genetic polymorphism. Glycoconj J Jun 14 (4), 415-422.
8. Bruno LS, Li X, Wang L, et al. (2005) Two-hybrid analysis of human salivary mucin MUC7 interactions. Biochim Biophys Acta 1746, 65-72.
9. Carraway KL, Ramsauer VP, Haq B, et al. (2003) Cell signalling through membrane mucins. Bioessays 25, 66-71.
10. Chaturvedi P, Singh AP, Batra SK (2007) Structure, evolution and biology of the MUC4 mucin. FASEB. pubmed ahead of print.
11. Corfield AP, Carroll D, Meyerscough N, Probert CS (2001) Mucins in the gastrointestinal tract in health and disease. Front Biosci 6, D1321-1357.
12. Croce MV, Price MR, Segal-Eiras A (2000) Detection and isolation of MUC1 mucin from larynx squamous cell carcinoma. Pathol Oncol Res 6, 93-99.
13. Dajani R, Zhang Y, Taft PJ, et al. (2005) Lysozyme secretion by submucosal glands protects the airway from bacterial infection. Am J Respir Cell Mol Biol 32, 548-552.
14. Davies JR, Kirkham S, Svitacheva N, Thornton DJ, Carlstedt I (2007) MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells. Int J Biochem Cell Biol 39, 1943-1954.
15. Fleming A (1932) Lysozyme. President's address. Proc R Soc Med 26 (Part I), 71-84.
16. Freeland AP, Nostrand AW (1975) The applied anatomy of the anterior commissure and subglottis. Can J Otolaryngol 4, 644-659.
17. Groneberg DA, Eynott PR, Oates T, et al. (2002) Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung. Respir Med 96, 81-86.
18. Groneberg DA, Peiser C, Dinh QT, et al. (2003) Distribution of respiratory mucin proteins in human nasal mucosa. Laryngoscope 113, 520-524.
19. Hiller AS, Kracke A, Tscherning T (1997) Comparison of the immunohistology of mucosa-associated lymphoid tissue in the larynx and lungs in sudden infant death and controls. Int J Legal Med 110, 316-322.
20. Hiller AS, Tschernig T, Kleemann WJ, Pabst R (1998) Bronchus-associated lymphoid tissue (BALT) and Larynx-associated Lymphoid Tissue (LALT) are found at different frequencies in children, adolescents and adults. Scand J Immunol 47, 159-162.
21. Hollingsworth MA, Swanson BJ (2004) Mucins in cancer: Protection and control of the cell surface. Nature Rev Cancer 4, 45-60.
22. Jäger K, Wu G, Sel S, Garreis F, Bräuer L, Paulsen F (2007) MUC16 in the lacrimal apparatus. Histochem Cell Biol 127, 433-438.
23. Jeannon JP, Stafford FW, Soames JV, Wilson JA (2001) Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer. Otolaryngol Head Neck Surg 124, 199-202.
24. Komatsu M, Jepson S, Arango ME, et al. (2001) Muc4/sialomucin complex, an intramembrane modulator of ErbB2/HER2/Neu, potentiates primary tumor growth and suppresses apoptosis in a xenotransplanted tumor. Oncogene 20, 461-470.
25. Kracke A, Hiller AS, Tschernig T (1997) Larynx-associated lymphoid tissue (LALT) in young children. Anat Rec 248, 413-420.
26. Kutta H, Steven P, Kohla G, Tillmann B, Paulsen FP (2002) The human false vocal folds - an analysis of antimicrobial defence mechanisms. Anat Embryol 205, 315-323.
27. Kutta H, Steven P, Tillmann B, Tsokos M, Paulsen F (2003) Region-specific immunological response of the different laryngeal compartments: Significance of larynx-associated lymphoid tissue. Cell Tissue Res 311, 365-371.
28. Kutta H, Steven P, Varoga D, Paulsen FP (2004) TFF peptides in the human false vocal folds of the larynx. Peptides 25, 811-818.
29. Kutta H, Steven P, Paulsen F (2006) Anatomical definition of the subglottic region. Cells Tissues Organs 184, 205-214.
30. Laube DM, Yim S, Ryan LK, Kisich KO, Diamond G (2006) Antimicrobial peptides in the airway. Curr Top Microbiol Immunol 306, 153-182.
31. Legrand D, Elass E, Carpentier M, Mazurier J (2005) Lactoferrin: A modulator of immune and inflammatory responses. Cell Mol Life Sci Nov 62 (22), 2549-2559. Review.
32. Leikauf GD, Borchers MT, Prows DR, Simpson LG (2002) Mucin apoprotein expression in COPD. Chest 121, 166S-182S.
33. Li S, Intini G, Bobek LA (2006) Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo. Am J Respir Cell Mol Biol 35, 95-102.
34. Lillehoj EP, Hyun SW, Kim BT, et al. (2001) Muc1 mucins on the cell surface are adhesion sites for pseudomonas aeruginosa. Am J Physiol Lung Cell Mol Physiol 280, 181-187.
35. Nakagawa H, Fukuda H, Kawaida M, Shiotani A, Kanzaki J (1998) Lubrication mechanism of the larynx during phonation: An experiment in excised canine larynges. Folia Phoniatr Logop 50 (4), 183-194.
36. Nassar VH, Bridger GB (1971) Topography of the laryngeal mucous glands. Arch Otolaryngol 94, 490.
37. Paleri V, Pearson JP, Bulmer D, Jeannon JP, Wight RG, Wilson JA (2004) Expression of mucin gene products in laryngeal squamous cancer. Otolaryngol Head Neck Surg 131, 84-88.
38. Paulsen F (2006) Cell and molecular biology of human lacrimal gland and nasolacrimal duct mucins. Int Rev Cytol 249, 229-279.
39. Paulsen F, Berry M (2006) Mucins and TFF peptides of the tear film and lacrimal apparatus. Prog Histochem Cytochem 41, 1-53.
40. Paulsen F, Corfield A Hinz M, et al. (2003) Characterization of mucins in human lacrimal sac and nasolacrimal duct. Invest Ophthalmol Vis Sci 44, 1807-1813.
41. Paulsen F, Jäger K, Worlitzsch D, et al. (2008) Regulation of MUC16 by inflammatory mediators in ocular surface epithelial cell lines. Ann Anat 190, 59-70.
42. Paulsen F, Langer G, Hoffmann W, Berry M (2004) Human lacrimal gland mucins. Cell Tissue Res May 316 (2), 167-177. Epub 2004 Mar 30.
43. Rose MC, Voynow JA (2006) Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol Rev 86, 245-278.
44. Seong JK, Koo JS, Lee WJ, et al. (2002) Upregulation of MUC8 and downregulation of MUC5AC by inflammatory mediators in human nasal polyps and cultured nasal epithelium. Acta Otolarygol 122, 401-407.
45. Singh PK, Tack BF, McCray PB, Welsh MJ (2000) Synergistic and additive killing by antimicrobial factors found in human airway surface liquid. Am J Physiol Lung Cell Mol Physiol 279, 799-805.
46. Smorodinsky N, Weiss M, Harmann ML, et al. (1996) Detection of a secreted MUC1/SEC protein by MUC1 isofrom specific monoclonal antibodies. Biochem Biophys Res Commun 228, 115-121.
47. Tabak LA (1995) In defense of the oral cavity: Structure, biosynthesis, and function of salivary mucins. Annu Rev Physiol 57, 547-564.
48. Thim L, Madsen F, Poulsen SS (2002) Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest Jul 32 (7), 519-527.
49. Thornton DJ, Rousseau K, McGuckin MA (2007) Structure and function of the polymeric mucins in airways mucus. Ann Rev Physiol, Epub ahead of print.
50. Valenti P, Antonini G (2005) Lactoferrin: An important host defence against microbial and viral attack. Cell Mol Life Sci Nov 62 (22), 2576-2587. Review.
51. Wickström C, Christersson C, Davies JR, Carlstedt I (2000) Macromolecular organization of saliva: Identification of 'insoluble' MUC5B assemblies and non-mucin proteins in the gel phase. Biochem J 351, 421-428.
52. Wickström C, Davies JR, Eriksen GV, Veerman EC, Carlstedt I (1998) MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-termial cleavage. Biochem J 334, 685-693.
53. Wilhelmus KR (1985) The importance of having lysozyme. Cornea 4, 69-70.
54. Yin BW, Lloyd KO (2001) Molecular cloning of the CA125 ovarian cancer antigen: Identification as a new mucin, MUC16. J Biol Chem 276, 27371-27375.