An efficient and large-scale enantioselective synthesis of PNP405: A purine nucleoside phosphorylase inhibitor

Journal of Organic Chemistry

Volumn 67, Issue 19, 2002, Pages 6612-6617

  Prashad, Mahavir ^a   Har, Denis ^a,b   Chen, Lijian ^a   Kim, Hong Yong ^a   Repič, Oljan ^a   Blacklock, Thomas J ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVE SYNTHESIS;

ALCOHOLS; ALKYLATION; CATALYSIS; ETHERS; SYNTHESIS (CHEMICAL);

ORGANIC CHEMICALS;

2 AMINO 7 [1 (2 FLUOROPHENYL) 2 HYDROXYETHYL] 3,5 DIHYDRO 4H PYRROLO[3,2 D]PYRIMIDIN 4 ONE; 2 FLUOROPHENYLACETIC ACID; ACETIC ACID DERIVATIVE; ALCOHOL DERIVATIVE; CYANAMIDE; GAMMA CYANOALCOHOL; PNP 405; PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR; SODIUM BOROHYDRIDE; TRIETHYLAMINE; TRIFLUOROACETIC ACID; TRITYL DERIVATIVE; TRITYLALCOHOL; TRITYLCHLORIDE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; DRUG PURITY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; METHODOLOGY;

CATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; ENZYME INHIBITORS; FLUOROBENZENES; MOLECULAR STRUCTURE; PURINE-NUCLEOSIDE PHOSPHORYLASE; PYRIMIDINONES; STEREOISOMERISM;

EID: 0037144629     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo020256i     Document Type: Article

References (11)