Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects

Contact Dermatitis

Volumn 59, Issue 4, 2008, Pages 212-219

  Borregaard, Jeanett ^a   Skov, Lone ^a   Wang, Lisy ^b   Ting, Naitee ^b   Wang, Cunshan ^b   Beck, Lisa A ^c   Sonne, Jesper ^a   Clucas, Alan ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b PFIZER INC   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Allergic contact dermatitis; CC chemokine receptor 1 antagonist; Chemokines

Indexed keywords

ANTIALLERGIC AGENT; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; CP 481715; NICKEL SULFATE; PLACEBO; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; CELL COUNT; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG SAFETY; DRUG TOLERABILITY; ERYTHEMA; FEMALE; FLATULENCE; HEADACHE; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; MALE; MULTICENTER STUDY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SKIN ALLERGY; SKIN BIOPSY;

DERMATITIS, ALLERGIC CONTACT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IRRITANTS; MALE; NICKEL; QUINOXALINES; RECEPTORS, CCR1;

EID: 53149105176     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2008.01365.x     Document Type: Article

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