Drug-elicited systemic allergic (contact) dermatitis - Update and possible pathomechanisms

Contact Dermatitis

Volumn 59, Issue 4, 2008, Pages 195-202

  Thyssen, Jacob Pontoppidan ^a   Maibach, Howard Ira ^b  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Baboon syndrome; Contact allergy; Drugs; Immunology; Medication; Orally elicitated; Pathomechanism; Reactivation; Systemic allergic dermatitis; Systemic contact dermatitis

Indexed keywords

ACETYLSALICYLIC ACID; ACICLOVIR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPRENOLOL; AMINOPHYLLINE; AMLEXANOX; AMOXICILLIN; BARIUM SULFATE; CAPTOPRIL; CEFTRIAXONE; CETIRIZINE; CHLORAMPHENICOL; CIMETIDINE; CINCHOCAINE; CLINDAMYCIN; CLIOQUINOL; CLOBAZAM; CLONIDINE; CODEINE; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; DIMETHYL SULFOXIDE; DIPHENHYDRAMINE; GOLD; HAPTEN; MERCURY; MITOMYCIN C; NICKEL; PREDNISOLONE; UNINDEXED DRUG;

CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; CONTACT DERMATITIS; CYTOKINE RELEASE; DELAYED HYPERSENSITIVITY; DISEASE CLASSIFICATION; DRUG INDUCED DISEASE; DRUG PROTEIN BINDING; ERYTHEMA; GENETIC PREDISPOSITION; HISTOPATHOLOGY; HUMAN; HYPERSENSITIVITY; IMMUNITY; IMMUNOPATHOGENESIS; LYMPHOCYTE FUNCTION; PATIENT CARE; REVIEW; RISK FACTOR; T LYMPHOCYTE ACTIVATION;

ALLERGENS; DELAYED-ACTION PREPARATIONS; DERMATITIS, ALLERGIC CONTACT; DRUG CARRIERS; DRUG ERUPTIONS; HAPTENS; HUMANS; HYPERSENSITIVITY, DELAYED;

EID: 53149103245     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/j.1600-0536.2008.01367.x     Document Type: Review

References (78)

1. Jadassohn J. Zur kenntnis der medikamentössen dermatosen. Verhandlungen der Deutschen Dermatologischen Gesellschaft. Fünfter Kongress, Raz, 1895, Vienna : Braunmüller, 1896 : p. 106.
2. Nakayama H, Niki F, Shono M, Hada S. Mercury exanthem. Contact Dermatitis 1983 : 9 : 411 417.
3. Wolf R, Orion E, Matz H. The baboon syndrome or intertriginous drug eruption: a report of eleven cases and a second look at its pathomechanism. Dermatol Online J 2003 : 9 : 2.
4. Ratner J H, Spencer S K, Grainge J M. Cashew nut dermatitis. An example of internal-external contact-type hypersensitivity. Arch Dermatol 1974 : 110 : 921 923.
5. Menné T, Veien N, Sjølin K E, Maibach H I. Systemic contact dermatitis. Am J Contact Dermat 1994 : 5 : 1 12.
6. Andersen K E, Hjorth N, Menné T. The baboon syndrome: systemically induced allergic contact dermatitis. Contact Dermatitis 1984 : 10 : 97 100.
7. Häusermann P, Harr T, Bircher A J. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Contact Dermatitis 2004 : 51 : 297 310.
8. Edwards I R, Aronson J K. Adverse drug reactions: definitions, diagnosis, and management. Lancet 2000 : 356 : 1255 1259.
9. Lachapalle J-M, Maibach H I. The Allergic Contact Dermatitis Syndrome. Patch Testing and Prick Testing. Berlin-Heidelberg, Springer, 2003 : 11 18.
10. Barbaud A, Goncalo M, Bruynzeel D, Bircher A. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reactions. Contact Dermatitis 2001 : 45 : 321 328.
11. Borch J E, Andersen K E, Bindslev-Jensen C. The prevalence of acute cutaneous drug reactions in a Scandinavian university hospital. Acta Derm Venereol 2006 : 86 : 518 522.
12. Hernandez-Salazar A, Rosales S P, Rangel-Frausto S, Criollo E, Archer-Dubon C, Orozco-Topete R. Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients. Arch Med Res 2006 : 37 : 899 902.
13. Veien N, Menné T. Systemic contact dermatitis. In : Contact Dermatitis, Frosch P J, Menné T, Lepoittevin J-P (eds Berlin-Heidelberg, Springer, 2006 : 295 307.
14. Moreno-Ramirez D, Garcia-Bravo B, Pichardo A R, Rubio F P, Martinez F C. Baboon syndrome in childhood: easy to avoid, easy to diagnose, but the problem continues. Pediatr Dermatol 2004 : 21 : 250 253.
15. Goossens C, Sass U, Song M. Baboon syndrome. Dermatology 1997 : 194 : 421 422.
16. Garcia-Menaya J, Cordobes-Duran C, Lamilla A, Moreno I, Bobadilla P. Baboon Syndrome: two simultaneous cases in the same family. Allergy 2007 : 62 (Suppl. 83 310.
17. Park R G. Cutaneous hypersensitivity to sulphonamides. Br Med J 1943 : 2 : 69 72.
18. Irion R, Gall H, Peter R U. Delayed-type hypersensitivity to heparin with tolerance of its intravenous administration. Contact Dermatitis 2000 : 43 : 249 250.
19. Boehncke W H, Gall H. Type-IV hypersensitivity to topical estradiol in a patient tolerant to it orally. Contact Dermatitis 1996 : 35 : 187 188.
20. Oh S H, Haw C R, Lee M H. Clinical and immunologic features of systemic contact dermatitis from ingestion of Rhus (Toxicodendron). Contact Dermatitis 2003 : 48 : 251 254.
21. Barbaud A, Trechot P, Granel F, Lonchamp P, Faure G, Schmutz J L, Bene M C. A baboon syndrome induced by intravenous human immunoglobulins: report of a case and immunological analysis. Dermatology 1999 : 199 : 258 260.
22. Posadas S J, Pichler W J. Delayed drug hypersensitivity reactions - new concepts. Clin Exp Allergy 2007 : 37 : 989 999.
23. Rustemeyer T, van Hoogstraten I M W, von Blomberg B M E, Scheper R J. Mechanisms in allergic contact dermatitis. In : Contact Dermatitis, Frosch P J, Menné T, Lepoittevin J-P (eds Heidelberg, Springer, 2006 : 11 33.
24. Polak L, Turk J L. Studies on the effect of systemic administration of sensitizers in guinea-pigs with contact sensitivity to inorganic metal compounds. I. The induction of immunological unresponsiveness in already sensitized animals. Clin Exp Immunol 1968 : 3 : 245 251.
25. Veien N K, Christiansen A H, Svejgaard E, Kaaber K. Antibodies against nickel-albumin in rabbits and man. Contact Dermatitis 1979 : 5 : 378 382.
26. Kunkeler L, Nieboer C, Bruynzeel D P. Type III and type IV hypersensitivity reactions due to mitomycin C. Contact Dermatitis 2000 : 42 : 74 76.
27. Arnold A W, Häusermann P, Bach S, Bircher A J. Recurrent flexural exanthema (SDRIFE or baboon syndrome) after administration of two different iodinated radio contrast media. Dermatology 2007 : 214 : 89 93.
28. Gawkrodger D J, McVittie E, Hunter J A. Immunophenotyping of the eczematous flare-up reaction in a nickel-sensitive subject. Dermatologica 1987 : 175 : 171 177.
29. Di G M, Masci S, Cavallucci E, Pavone G, Andreassi M, Gravante M, Pizzicanella G, Boscolo P. [Immunohistopathologic changes in the gastrointestinal mucosa in patients with nickel contact allergy]. G Ital Med Lav 1995 : 17 : 33 36.
30. Boscolo P, Andreassi M, Sabbioni E, Reale M, Conti P, Amerio P, Di Gioacchino M. Systemic effects of ingested nickel on the immune system of nickel sensitised women. Life Sci 1999 : 64 : 1485 1491.
31. Di G M, Boscolo P, Cavallucci E et al. Lymphocyte subset changes in blood and gastrointestinal mucosa after oral nickel challenge in nickel-sensitized women. Contact Dermatitis 2000 : 43 : 206 211.
32. Jensen C S, Lisby S, Larsen J K, Veien N K, Menné T. Characterization of lymphocyte subpopulations and cytokine profiles in peripheral blood of nickel-sensitive individuals with systemic contact dermatitis after oral nickel exposure. Contact Dermatitis 2004 : 50 : 31 38.
33. Möller H, Ohlsson K, Linder C, Björkner B, Bruze M. Cytokines and acute phase reactants during flare-up of contact allergy to gold. Am J Contact Dermat 1998 : 9 : 15 22.
34. Möller H, Ohlsson K, Linder C, Björkner B, Bruze M. The flare-up reactions after systemic provocation in contact allergy to nickel and gold. Contact Dermatitis 1999 : 40 : 200 204.
35. Yawalkar N, Hari Y, Helbing A, von G S, Kappeler A, Baathen L R, Pichler W J. Elevated serum levels of interleukins 5, 6, and 10 in a patient with drug-induced exanthem caused by systemic corticosteroids. J Am Acad Dermatol 1998 : 39 (Pt 1 790 793.
36. Yanagi T, Kodama K, Yoshihisa Y, Shimizu H, Shimizu T. Macrophage migration inhibitory factor in zinc-allergic systemic contact dermatitis. Cytokine 2006 : 35 : 270 274.
37. Shimizu T, Abe R, Nishihira J et al. Impaired contact hypersensitivity in macrophage migration inhibitory factor-deficient mice. Eur J Immunol 2003 : 33 : 1478 1487.
38. Czarnobilska E, Thor P, Kaszuba-Zwoinska J, Slodowska-Hajduk Z, Stobiecki M, Dyga W, Wsolek K, Obtulowicz K. [Response of peripheral blood mononuclear leukocyte to nickel stimulation in patients with systemic and contact allergy to nickel]. Przegl Lek 2006 : 63 : 1276 1280.
39. Roychowdhury S, Svensson C K. Mechanisms of drug-induced delayed-type hypersensitivity reactions in the skin. AAPS J 2005 : 7 : E834 E846.
40. Schnyder B, Mauri-Hellweg D, Zanni M, Bettens F, Pichler W J. Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones. J Clin Invest 1997 : 100 : 136 141.
41. Zanni M P, von G S, Schnyder B, Brander K A, Frutig K, Hari Y, Valitutti S, Pichler W J. HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes. J Clin Invest 1998 : 102 : 1591 1598.
42. Ross C J, Katzov H, Carleton B, Hayden M R. Pharmacogenomics and its implications for autoimmune disease. J Autoimmun 2007 : 28 : 122 128.
43. Chung W H, Hung S I, Hong H S, Hsih M S, Yang L C, Ho H C, Wu J Y, Chen Y T et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature 2004 : 428 : 486.
44. Hetherington S, Hughes A R, Mosteller M et al. Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet 2002 : 359 : 1121 1122.
45. Mallal S, Nolan D, Witt C et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet 2002 : 359 : 727 732.
46. Pollack A. Drug makers seek clues to side effects in genes. New York Times, 2007 : p. 1.
47. Schwartz J B. The influence of sex on pharmacokinetics. Clin Pharmacokinet 2003 : 42 : 107 121.
48. Carbonin P, Pahor M, Bernabei R, Sgadari A. Is age an independent risk factor of adverse drug reactions in hospitalized medical patients? J Am Geriatr Soc 1991 : 39 : 1093 1099.
49. Roujeau J C. Immune mechanisms in drug allergy. Allergol Int 2006 : 55 : 27 33.
50. Williamson J, Chopin J M. Adverse reactions to prescribed drugs in the elderly: a multicentre investigation. Age Ageing 1980 : 9 : 73 80.
51. Menné T, Weismann K. [Hematogenous contact eczema following oral administration of neomycin]. Hautarzt 1984 : 35 : 319 320.
52. Hindson C. Contact eczema from methyl salicylate reproduced by oral aspirin (acetyl salicylic acid). Contact Dermatitis 1977 : 3 : 348 349.
53. Guin J D, Phillips D. Erythroderma from systemic contact dermatitis: a complication of systemic gentamicin in a patient with contact allergy to neomycin. Cutis 1989 : 43 : 564 567.
54. Meneghini C L, Angelini G. Secondary polymorphic eruptions in allergic contact dermatitis. Dermatologica 1981 : 163 : 63 70.
55. Ash S, Scheman A J. Systemic contact dermatitis to hydroxyzine. Am J Contact Dermat 1997 : 8 : 2 5.
56. Häusermann P, Bircher A J. SDRIFE - another acronym for a distinct cutaneous drug exanthema: do we really need it? Dermatology 2007 : 214 : 1 2.
57. Christensen O B, Lindstrom C, Lofberg H, Moller H. Micromorphology and specificity of orally induced flare-up reactions in nickel-sensitive patients. Acta Derm Venereol 1981 : 61 : 505 510.
58. Sjoborg S, Andersson A, Christensen O B. The Langerhans cells in healed patch tests reactions, before and after oral administration of nickel. Acta Derm Venereol Suppl (Stockh) 1984 : 111 : 1 20.
59. Veien N, Menné T, Maibach H I. Systemic contact dermatitis. In : Dermatotoxicology, Zhai H, Maibach H I (eds Boca Raton, CRC Press, 2004 : 285 320.
60. Panhans-Gross A, Gall H, Peter R U. Baboon syndrome after oral penicillin. Contact Dermatitis 1999 : 41 : 352 353.
61. Sanchez T S, Sanchez-Perez J, Aragues M, Garcia-Diaz A. Flare-up reaction of pseudoephedrine baboon syndrome after positive patch test. Contact Dermatitis 2000 : 42 : 312 313.
62. Jankowska-Konsur A, Kolodziej T, Szepietowski J, Sikora J, Maj J, Baran E. The baboon syndrome - report of two first cases in Poland. Contact Dermatitis 2005 : 52 : 289 290.
63. Kaya G, Touati-Serraj M, Perriard J, Saurat J H, Chavaz P. Giant cell lichenoid dermatitis in a patient with Baboon syndrome. J Invest Dermatol 2002 : 119 : 333 334.
64. Fisher A A. Systemic contact-type dermatitis due to drugs. Clin Dermatol 1986 : 4 : 58 69.
65. Calkin J M, Maibach H I. Delayed hypersensitivity drug reactions diagnosed by patch testing. Contact Dermatitis 1993 : 29 : 223 233.
66. Bruynzeel D P, Maibach H I. Patch testing in systemic drug eruptions. Clin Dermatol 1997 : 15 : 479 484.
67. Barbaud A. Drug patch testing in systemic cutaneous drug allergy. Toxicology 2005 : 209 : 209 216.
68. Lammintausta K, Kortekangas-Savolainen O. The usefulness of skin tests to prove drug hypersensitivity. Br J Dermatol 2005 : 152 : 968 974.
69. Romano A, Demoly P. Recent advances in the diagnosis of drug allergy. Curr Opin Allergy Clin Immunol 2007 : 7 : 299 303.
70. Chew A L, Maibach H I. Multiple corticosteroid orally elicited allergic contact dermatitis in a patient with multiple topical corticosteroid allergic contact dermatitis. Cutis 2000 : 65 : 307 311.
71. Alanko K, Stubb S, Kauppinen K. Cutaneous drug reactions: clinical types and causative agents. A five-year survey of in-patients (1981-1985). Acta Derm Venereol 1989 : 69 : 223 226.
72. Brandao F M, Goossens A, Tosti A. Topical drugs. In : Contact Dermatitis, Frosch P J, Menné T, Lepoittevin J-P (eds Berlin-Heidelberg, Springer, 2006 : 623 652.
73. Delgado J, Quiralte J, Castillo R, Blanco C, Molero R, Carrillo T. Systemic contact dermatitis from suxamethonium. Contact Dermatitis 1996 : 35 : 120 121.
74. Meseguer J, Sastre A, Malek T, Salvador M D. Systemic contact dermatitis from isoniazid. Contact Dermatitis 1993 : 28 : 110 111.
75. Lijnen R L, de G L. Systemic contact dermatitis from tamsulosin. Contact Dermatitis 2003 : 49 : 50 51.
76. Jaeger C, Jappe U. Valdecoxib-induced systemic contact dermatitis confirmed by positive patch test. Contact Dermatitis 2005 : 52 : 47 48.
77. De Castro Martinez F J, Ruiz F J, Tornero P, De B M, Prieto A. Systemic contact dermatitis due to fusidic acid. Contact Dermatitis 2006 : 54 : 169.
78. Michel M, Dompmartin A, Szczurko C, Castel B, Moreau A, Leroy D. Eczematous-like drug eruption induced by synergistins. Contact Dermatitis 1996 : 34 : 86 87.