The baboon syndrome or intertriginous drug eruption: A report of eleven cases and a second look at its pathomechanism

Dermatology Online Journal

Volumn 9, Issue 3, 2003, Pages 13-27

  Wolf, Ronni ^a   Orion, Edith ^a   Matz, Hagit ^a,b  

^a KAPLAN MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; BIFONAZOLE; BIFONAZOLE PLUS FLUOCINONIDE; CEFALEXIN; CEFTRIAXONE; CEFUROXIME; CEFUROXIME AXETIL; CIPROFLOXACIN; CLARITHROMYCIN; CLINDAMYCIN; CLOXACILLIN; CONTACT ALLERGEN; DIFLUCORTOLONE VALERATE; FLUOCINONIDE; GENTAMICIN; HYDROXYZINE; ISOCONAZOLE; NAPROXEN; OMEPRAZOLE; PERCODAN; UNCLASSIFIED DRUG; VANCOMYCIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BABOON SYNDROME; CANDIDIASIS; CASE REPORT; CLINICAL FEATURE; CONTACT DERMATITIS; DERMATITIS; DIFFERENTIAL DIAGNOSIS; DRUG ERUPTION; EROSION; ERYTHEMA; ERYTHEMA MULTIFORME; HISTOPATHOLOGY; HUMAN; INTERTRIGO; MALE; PATCH TEST; PATHOPHYSIOLOGY; PENICILLIN ALLERGY; PURPURA; RASH; RECALL; SENSITIZATION; TISSUE DISTRIBUTION;

EID: 3042726457     PISSN: 10872108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Andersen K, Hjorth N, Menne T. The baboon syndrome: Systemically-induced allergic contact dermatitis. Contact Dermatitis. 1984; 10: 97-100.
2. Gonzalo M, Alvarado M, Fernandez L, Rosendo R, Gonzalez G. Fixed drug eruption due to naproxen; lack of cross-reactivity with other propionic acid derivatives. Br J Dermatol. 2001; 144: 1291-1292.
3. Lachapelle J, Ale S, Freeman S, et al. Proposal for a revised international standard series of patch tests. Contact Dermatitis. 1997; 36: 121-123.
4. Barbaud A, Reichert-Penetrat S, Trechot P, et al. The use of skin testing in the investigation of cutaneous adverse drug reactions. Br J Dermatol. 1998; 139: 49-58.
5. Barbaud A, Goncalo M, Bruynzeel D, Bircher A. Guidelines for performing skin tests with drugs in the investigation of cutaneous adverse drug reaction. Contact Dermatitis. 2001; 45: 321-328.
6. Wakelin S, Sidhu S, Orton D, Chia Y, Shaw S. Amoxycillin-induced flexural exanthem. Clin Exp Dermatol. 1999; 24: 71-73.
7. Wolf R, Brenner S, Krakowski A. Intertriginous drug eruption. Acta Derm Venereol (Stockholm). 1992; 72: 441-442.
8. Wolf R, Elman M, Brenner S. Drug-induced "intertrigo". Int J Dermatol. 1993; 32: 515-516.
9. Herfs H, Schirren C, Przybilla B, Plewig G. Das "Baboon-syndrome. " Hautarzt. 1993; 44: 466-469.
10. Pfeiff B, Pullmann H. Baboon-artiges Arzeneiexanthem auf Heparin. Deutscher Dermatologe. 1991; 1991: 559-560.
11. Menne T, Weisman K. Haematogenes kontaktekzem nach oraler Gave von Neomyzin. Hautarzt. 1984; 35: 319-320.
12. Duve S, Worret W, Hofmann H. The baboon syndrome: a manifestation of haematogenous contact-type dermatitis. Acta Derm Venereol (Stockh). 1994; 74: 480-481.
13. Menne, T and Sjolin, KE. Systemic contact dermatitis: a model of unexplored clinical information. 1992. New York, 18th World Congress of Dermatology. (GENERIC) Ref Type: Conference Proceeding
14. Helmbold P, Hegemann B, Dickert C, Marsch W. Symmetric ptychotropic and nonpigmenting fixed drug eruption due to cimetidine (so-called baboon syndrome). Dermatology. 1998; 197: 402-403.
15. Guin J, Fields P, Thomas K. Baboon syndrome from I.V. aminophylline in a patient allergic to ethylenediamine. Contact Dermatitis. 1999; 40: 170-171.
16. Chowdhury M, Patel G, Inaloz H, Holt P. Hydroxyurea-induced skin diseases mimicking the baboon syndrome. Clin Exp Dermatol. 1999; 24: 336-337.
17. Panhans-Gross A, Gall H, Peter R. Baboon syndrome after oral penicillin. Contact Dermatitis. 1999; 41: 352-353.
18. Sanchez T, Sachez-Perez J, Aragues M, Garcia-Diez A. Flare-up reaction of pseudoephedrine baboon syndrome after positive patch test. Contact Dermatitis. 2000; 42: 312-313.
19. Bartolome B, Cordoba S, Sanchez-Perez J, Fernandez-Herrera J, Garcia-Diez A. Boboon syndrome of unusual origin. Contact Dermatitis. 2000; 43: 113
20. Kick G, Przybilla B. Delayed prick test reaction identifies amoxicillin as elicitor of baboon syndrome. Contact Dermatitis. 2000; 43: 366-367.
21. Audicana M, Bernedo N, Gonzalez I, Munoz D, Fernandez E, Gastaminza G. An unusual case of baboon syndrome due to mercury present in a homeopathic medicine. Contact Dermatitis. 2001; 45: 185
22. Strub C, Bircher A. Exanthema with emphasis of body flexure points 10 hours after administration of amoxicillin, "baboon syndrome". Schweiz Runsch Med Prax. 2002; 91: 232-234.
23. Amichai B, Grunwald M. Baboon syndrome following oral roxithromycin [Letter]. Clin Exp Dermatol. 2002; 27: 523
24. Cronin E. Ekzematose Reaktionen bei innerlicher Aufnahme von Kontaktallerenen. Hautarzt. 1975; 26: 68-71.
25. Kohler L, Schonlein K, Kautzky F, Vogt H. Diagnosis at first glance: the baboon syndrome. Int J Dermatol. 1996; 35: 502-503.
26. Le Coz C, Boos V, Cribier B, Grosshans E, Heid E. An unusual case of mercurial baboon syndrome. Contact Dermatitis. 1996; 35: 112
27. Isaksson M, Ljunggren B. Systemic contact dermatitis from ethylenediamine in an aminophylline preparation presenting as the baboon syndrome [Letter]. Acta Derm Venereol (Stockh). 2003; 83: 69-70.
28. Proske S, Uter W, Schnuch A, Hartschuh W. Severe allergic contact dermatitis with generalized spread due to bufexamac presenting as the "baboon" syndrome. Dtsch Med Wochenshcr. 2003; 128: 545-547.
29. Happle R. Paraptisches Ekzem. Hautarzt. 1994; 45: 1-3.
30. Cronin E. Reactions to contact allergens given orally or systematically. Br J Dermatol. 1972; 86: 104-107.
31. Fisher A. Systemic contact-type dermatitis. In: Fisher A, ed. Contact Dermatitis. Philadelphia, PA: Lea & Febiger; 1986: 119-129.
32. Menne T, Veien N, Maibach H. Systemic contact-type dermatitis due to drugs. Semin Dermatol. 1989; 8: 144-148.
33. Veien N. Systemically induced eczema in adults. Acta Derm Venereol (Stockh). 1989;Suppl 147: 1-58.
34. Wolf, R and Brenner, S. Drug induced dermatologic mimicry. 1993. Copenhagen-Denmark, 3rd EADV Congress. (GENERIC) Ref Type: Conference Proceeding
35. Cohen I, Master M, O'Keefe E, et al. Cutanrous toxicity of bleomycin therapy. Arch Dermatol. 1973; 107: 553-555.
36. Abig J, Gollnick H, Detmar M, Orfanos C. Flagellatartige hyperpigmentierung durch bleomycin. Hautarzt. 1992; 43: 376-379.
37. Tsuji R, Sawabe M. Hyperpigmentation in striae distensae after bleomycin treatment. J Am Acad Dermatol. 1993; 28: 503-505.
38. Yamamoto T, Yokizeki H, Nishioka K. Dermal sclerosis in the lesional skin of 'flagellate' erythema (scratch dermatitis) induced by bleomycin. Dermatology. 1998; 197: 399-400.
39. Wheeland R, Burgdorf W, Humphrey G. The flag sign of chemotherapy. Cancer. 1963; 51: 1356-1358.
40. Lim J, Ng S. An unusual drug eruption to ampicillin. Cutis. 1995; 56: 163-164.
41. Burgdorf W, Gilmore W, Garick R. Peculair acral erythema secondary to high-dose chemotherapy for acute myelogenous leukemia. Ann Intern Med. 1982; 97: 61-62.
42. Lokich J, Moore C. Chemotherapy associated palmar-plantar erythrodysesthesia syndrome. Ann Intern Med. 1984; 101: 798-800.
43. Jucgla A, Sais G, Navarro M, Peyri J. Palmoplantar keratoderma secondary to chronic acral erythema due to Tegaful. Arch Dermatol. 1995; 131: 364-365.
44. Ueki H, Namba M. Arzeneimittelexanthem durch ein neues 5-Rluorouracilderivat. Hautarzt. 1980; 31: 207-208.
45. Baack B, Furgdorf W. Chemotherapy-induced acral erythema. J Am Acad Dermatol. 1991; 24: 457-461.
46. Rios-Buceta L, Buezo G, Peoas P, Dauden E, Fernandez-Herrera J, Garcia-Diez A. Palmar-plantar erythrodysaesthesia syndrome and other cutaneous side-effects after treatment with Tegafur. Acta Derm Venereol (Stockh). 1997; 77: 80-81.
47. Azurdia R, Clark R, Friedmann P. Chemotherapy-induced acral erythema (CIAE) with bullous reaction. Clin Exp Dermatol. 1999; 24: 64-66.
48. Prussick R, Horn T, Wilson W, Turner M. A characteristic eruption associated with ifosfamide, carboplatin, and etoposide chemotherapy after pre-treatment with recombinant interleukin-1a. J Am Acad Dermatol. 1996; 35: 705-709.
49. Valks R, Fraga J, Porras-luque J, Figuuera A, Garcia-Diez A, Fernandez-Herrera J. Chemotherapy-induced eccrine squamous syringometaplasia. A distinctive eruption in patients receiving hematopoietic progenitor cells. Arch Dermatol. 1997; 133: 873-878.
50. Lotem M, Hubert A, Lyass O, et al. Skin toxic effects of polyethylene glycol-coated liposomal doxorubicin. Arch Dermatol. 2000; 136: 1475-1480.
51. Brazzelli V, Ardigo M, Chiesa M, et al. Flexural erythematous eruption following autologous peripheral blood stem cell transplantation: a study of four cases. Br J Dermatol. 2001; 145: 490-495.
52. Maders S, Heymann W, Atillasoy E, Kleeman J, Schlievert P. Recurrent toxin-mediated perineal erythema. Arch Dermatol. 1996; 132: 57-60.
53. Ichimiya M, Hamamoto Y, Muto M. A case of baboon syndrome associated with group a streptococcal infection. J Dermatol. 2003; 30: 69-71.
54. Barbaud A, Trechot P, Granel F, et al. A baboon syndrome induced by intravenous human immunoglobulins: report of a case and immunological analysis. Dermatology. 1999; 199: 258-260.
55. Weiss J, Mockenhaupt M, Schopf E, Simon J. Reproducible drug examthema to terbinafine with characteristic distribution of baboon syndrome. Hautarzt. 2001; 52: 1104-1106.
56. Bruynzeel D, Von Blomberg-van der Flier M, Scheper Real. Allergy for penicillin and the relevance of epicutaneous tests. Dermatologica. 1985; 171: 429-434.
57. Bruynzeel D, Van Ketel W. Parch testing in drug erupitons. Semin Dermatol. 1989; 8: 196-203.
58. Alanko K, Stubb S, Reitamo S. Topical provocation of fixed drug eruption. Br J Dermatol. 1987; 116: 561-567.
59. Barbaud A, Bene M, Faure G, Schmutz J. Tests cutanes dans l'exploration des toxidermies supposees de mecanisme immuno-allergique. Bull Acad Natle Med. 2000; 184: 47-63.
60. Barbaud A, Trechot P, Reichert-Penetrat S, Commun N, Schmutz J. Relevance of skin tests with drugs in investigating cutaneous adverse drug reactions. Contact Dermatitis. 2001; 45: 265-268.
61. Nakayama H, Niki F, Shono M, Hada S. Mercury exanthem. Contact Dermatitis. 1983; 9: 411-417.
62. Fernandez L, Maquiera E, Garcia-Abujeta J, et al. Baboon syndrome due to mercury sensitivity. Contact Dermatitis. 1995; 33: 56-57.
63. Gallo R, Parodi A. Baboon syndrome from 5-aminosalicylic acid. Contact Dermatitis. 2002; 46: 110
64. Wolf R, Brenner S, Ruocco V, Filioli F. Isotopic response. Int J Dermatol. 1995; 102: 341-348.
65. Tuzun Y, Iscimen A, Goksugur N, Demirkesen C, Tuzun B. Wolf's isotopic response: Trichophyton rubrum folliculitis appearing on a herpes zoster scar. Int J Dermatol. 2000; 39: 766-768.
66. Ruocco V, Ruocco E, Ghersetich I, Bianchi B, Lotti T. Isotopic response after herpesvirus infection: An update. J Am Acad Dermatol. 2002; 46: 90-94.