Relationship between diabetic macular edema and peripheral Th1/Th2 balance

Ophthalmologica

Volumn 222, Issue 4, 2008, Pages 249-253

  Itoi, Kyoko ^a   Nakamura, Kimitoshi ^b   Oku, Hidehiro ^a   Ishizaki, Eisuke ^a   Sugiyama, Tetsuya ^a   Ueki, Mari ^a   Maeno, Takatoshi ^a   Sato, Bunpei ^a   Ikeda, Tsunehiko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b Nakamura Eye Clinic   (Japan)

Author keywords

Diabetic macular edema; Immune response; T helper cells; Th1 Th2 balance

Indexed keywords

CYTOKINE; HEMOGLOBIN A1C;

ADULT; AGE; ARTICLE; BLOOD SAMPLING; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC MACULAR EDEMA; DIABETIC PATIENT; DIABETIC RETINOPATHY; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HELPER CELL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LASER COAGULATION; LOGISTIC REGRESSION ANALYSIS; MALE; PATHOGENESIS; RETINA MACULA EDEMA; SEX DIFFERENCE; TH1 CELL; TH2 CELL; VISUAL ACUITY; CD4 LYMPHOCYTE COUNT; FLUORESCENCE ANGIOGRAPHY; IMMUNOLOGY; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS;

CD4 LYMPHOCYTE COUNT; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; FLOW CYTOMETRY; FLUORESCEIN ANGIOGRAPHY; HUMANS; LASER COAGULATION; MACULAR EDEMA; MALE; MIDDLE AGED; TH1 CELLS; TH2 CELLS; VISUAL ACUITY;

EID: 53049106273     PISSN: 00303755     EISSN: None     Source Type: Journal    
DOI: 10.1159/000131105     Document Type: Article

References (31)

1. Funatsu H, Yamashita H, Ikeda T, Mimura T, Eguchi S, Hori S: Vitreous levels of interleukin-6 and vascular endothelial growth factor are related to diabetic macular edema. Ophthalmology 2003;110:1690-1696.
2. Zamiri P, Masli S, Kitaichi N, Taylor AW, Streilein JW: Thrombospondin plays a vital role in the immune privilege of the eye. Invest Ophthalmol Vis Sci 2005;46:908-919.
3. Canataroglu H, Varinli I, Ozcan AA, Canataroglu A, Doran F, Varinli S: Interleukin (IL)-6, interleukin (IL)-8 levels and cellular composition of the vitreous humor in proliferative diabetic retinopathy, proliferative vitreoretinopathy, and traumatic proliferative vitreoretinopathy. Ocul Immunol Inflamm 2005;13:375-381.
4. Kauffmann DJ, van Meurs JC, Mertens DA, Peperkamp E, Master C, Gerritsen ME: Cytokines in vitreous humor: interleukin-6 is elevated in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 1994;35:900-906.
5. Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW: Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 2005;54:1559-1565.
6. Meleth AD, Agron E, Chan CC, Reed GF, Arora K, Byrnes G, Csaky KG, Ferris FL 3rd, Chew EY: Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci 2005;46:4295-4301.
7. Dong C: Diversification of T-helper-cell lineages: finding the family root of IL-17-producing cells. Nat Rev Immunol 2006;6:329-333.
8. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
9. Del Prete GF, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, Ricci M, Romagnani S: Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest 1991;88:346-350.
10. Qaum T, Xu Q, Joussen AM, Clemens MW, Qin W, Miyamoto K, Hassessian H, Wiegand SJ, Rudge J, Yancopoulos GD, Adamis AP: VEGF-initiated blood-retinal barrier breakdown in early diabetes. Invest Ophthalmol Vis Sci 2001;42:2408-2413.
11. Naldini A, Pucci A, Bernini C, Carraro F: Regulation of angiogenesis by Th1- and Th2-type cytokines. Curr Pharm Des 2003;97:511-519.
12. Rocken M, Racke M, Shevach EM: IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol Today 1996;17:225-231.
13. Feman SS, Leonard-Martin TC, Andrews JS, Armbruster CC, Burdge TL, Debelak JD, Lanier A, Fischer AG: A quantitative system to evaluate diabetic retinopathy from fundus photographs. Invest Ophthalmol Vis Sci 1995;36:174-181.
14. Paludan SR: Interleukin-4 and interferon-gamma: the quintessence of a mutual antagonistic relationship. Scand J Immunol 1998;48:459-468.
15. Yin Z, Braun J, Neure L, Wu P, Liu L, Eggens U, Sieper J: Crucial role of interleukin-10/interleukin-12 balance in the regulation of the type 2 T helper cytokine response in reactive arthritis. Arthritis Rheum 1997;40:1788-1797.
16. Verhoef CM, van Roon JA, Vianen ME, Bruijnzeel-Koomen CA, Lafeber FP, Bijlsma JW: Mutual antagonism of rheumatoid arthritis and hay fever; a role for type 1/type 2 T cell balance. Ann Rheum Dis 1998;57:275-280.
17. Shirai T, Suzuki K, Inui N, Suda T, Chida K, Nakamura H: Th1/Th2 profile in peripheral blood in atopic cough and atopic asthma. Clin Exp Allergy 2003;33:84-89.
18. Xu Q, Cao J, Wu F, Hayakawa Y, Saiki I, Koda A: Role of Th1 and Th2 cytokines in regulating the liver injury induced by delayed-type hypersensitivity to picryl chloride. Liver 1999;19:473-480.
19. Nicholson LB, Kuchroo VK: Manipulation of the Th1/Th2 balance in autoimmune disease. Curr Opin Immunol 1996;8:837-842.
20. Fujisao S, Tsuda H: Th1/Th2 balance alteration in the clinical course of a patient with pure red cell aplasia and thymoma. Br J Haematol 1998;103:308-310.
21. Gurish MF, Boyce JA: Mast cell growth, differentiation, and death. Clin Rev Allergy Immunol 2002;22:107-118.
22. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Schou C, Beaty TH: Genetic basis of IgE responsiveness: relevance to the atopic diseases. Int Arch Allergy Immunol 1995;107:25-28.
23. Steptoe RJ, McMenamin PG, McMenamin C: Distribution and characterisation of rat choroidal mast cells. Br J Ophthalmol 1994;78:211-218.
24. May CA: Mast cell heterogeneity in the human uvea. Histochem Cell Biol 1999;112:381-386.
25. Norrby K: Mast cells and angiogenesis. APMIS 2002;110:355-371.
26. Boesiger J, Tsai M, Maurer M, Yamaguchi M, Brown LF, Claffey KP, Dvorak HF, Galli SJ: Mast cells can secrete vascular permeability factor/vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J Exp Med 1998;188:1135-1145.
27. Derevjanik NL, Vinores SA, Xiao WH, Mori K, Turon T, Hudish T, Dong S, Campochiaro PA: Quantitative assessment of the integrity of the blood-retinal barrier in mice. Invest Ophthalmol Vis Sci 2002;43:2462-2467.
28. Funatsu H, Yamashita H, Noma H, Mimura T, Nakamura S, Sakata K, Hori S: Aqueous humor levels of cytokines are related to vitreous levels and progression of diabetic retinopathy in diabetic patients. Graefes Arch Clin Exp Ophthalmol 2005;243:3-8.
29. McLeod DS, Lefer DJ, Merges C, Lutty GA: Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid. Am J Pathol 1995;147:642-653.
30. Funatsu H, Yamashita H, Sakata K, Noma H, Mimura T, Suzuki M, Eguchi S, Hori S: Vitreous levels of vascular endothelial growth factor and intercellular adhesion molecule 1 are related to diabetic macular edema. Ophthalmology 2005;112:806-816.
31. Ito T, Seo N, Yagi H, Ohtani T, Tokura Y, Takigawa M, Furukawa F: Unique therapeutic effects of the Japanese-Chinese herbal medicine, Sairei-to, on Th1/Th2 cytokines balance of the autoimmunity of MRL/lpr mice. J Dermatol Sci 2002;28:198-210.