p-Hydroxybenzyl alcohol attenuates learning deficits in the inhibitory avoidance task: Involvement of serotonergic and dopaminergic systems

Chinese Journal of Physiology

Volumn 39, Issue 4, 1996, Pages 265-273

  Wu, Chi Rei ^a   Hsieh, Ming Tsuen ^a   Liao, Jen ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b JEN AI HOSPITAL   (Taiwan)

Author keywords

inhibitory avoidance; learning acquisition; p hydroxybenzyl alcohol; piracetam

Indexed keywords

4 HYDROXYBENZYL ALCOHOL; APOMORPHINE; BENZYL ALCOHOL DERIVATIVE; CHLORAMPHETAMINE; PIRACETAM; SCOPOLAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING DISORDER; MALE; NONHUMAN; RAT; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030481745     PISSN: 03044920     EISSN: 26660059     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Feng, H.C. Studies on the constituents of Gastrodia elata. Acta Chemical Sinica 37: 175, 1979.
2. Deng, S.X. and Y.J. Mo. Pharmacological studies on Gastrodia elata Bluma: I. The sedative and anticonvulsant effects of synthetic gastrodin and its genin. Acta Botanica Yunnanica 1(2): 66-73, 1979.
3. Kao, N.N., S.Z. Yu, R.H. Liu, and C.T. Hsu. Improving effects of Gastrodia elata Bl on D-galactose-induced aging in mice. Chin. Trad. Herbal Drugs 25: 521-523, 1994.
4. Kao, N.N., S.Z. Yu, and C.T. Hsu. Improving effects of Gastrodia elata Bl on learning and memory in senescent mice. China J. Chinese Mat. Med. 20(9): 562-564, 1995.
5. Wu, C.R., M.T. Hsieh, S.C. Huang, W.H. Peng, Y.S. Chang, and C.F. Chen. Effects of Gastrodia elata and its active constitutes on scopolamine-induced amnesia in rats. Planta Medica 62: 317-321, 1996.
6. Guo, Z., T. Tan, Y. Zhong, and C. Wu. Study of the mechanism of gastrodin and derivatives of gastrodigenin. J. West China Univ. Med. Sci. 22: 79-82, 1991.
7. Izquierdo, I. Endogenous state dependency: memory depends on the relation between the neurohumoral and hormonal states present after training and at the time of testing. In: Neurobiology of learning and memory, edited by G. Lynch, J.L. McGaugh, and N.M. Weinberger. The Guilford Press, New York, 1984, pp. 333-350.
8. Jodar, L. and H. Kaneto. Synaptic plasticity: stairway to memory. Jpn. J. Pharmacol. 68: 359-387, 1995.
9. Blokland, A. Acetylcholine: a neurotransmitter for learning, memory? Brain Res. Rev. 21: 285-300, 1996.
10. Elrod, K. and J.J. Buccafusco. An evaluation of the mechanism of scopolamine-induced impairment in two inhibitory avoidance protocols. Pharmacol. Biochem. and Behav. 29: 15-21, 1988.
11. Rush, D.K. Scopolamine amnesia of inhibitory avoidance: A deficit of information acquisition. Behav. Neural Biol. 50: 255-274, 1988.
12. McEntee, W.J. and T.H. Crook. Serotonin, memory and the aging brain. Psychopharmacology 103: 143-149, 1991.
13. →gren, S.O. and C. Johansson. Separation of the associative and non-associative effects of brain serotonin released by p-chloroamphetamine: dissociable serotoninergic involvement in avoidance learning, pain and motor function. Psychopharmacology 86: 12-26, 1985.
14. White, N.M., M.G. Packard, and J. Seamans. Memory enhancement by post-training peripheral administration of low doses of dopamine agonists: Possible autoreceptor effect. Behav. Neural Biol. 59: 230-241, 1993.
15. Ichihara, K., T. Nabeshima, and T. Kameyama. Opposite effects induced by low and high doses of apomorphine on single-trial inhibitory avoidance learning in mice. Pharmacol. Biochem. and Behav. 30: 107-113, 1988.
16. Worms, P., C. Gueudet, A. P'erio, and P. Soubri'e. Systemic injection of pirenzepine induces a deficit in inhibitory avoidance learning in rats. Psychopharmacology 98: 286-288, 1989.
17. Sanberg, P.R., S.H. Hangenmeyer, and M.A. Henault. Automated measurement of multivariate locomotor behavior in rodents. Neurobehav. Toxicol. Teratol. 7:8 7-94, 1985.
18. Venable, N. and P.H. Kelly. Effects of NMDA receptor antagonists on inhibitory avoidance learning and retrieval in rats and mice. Psychopharmacology 100: 215-221, 1990,.
19. Weingartner, H. and J.C. Gillin. Human serial learning: enhancement either arecoline and choline and impairment with scopolamine. Science 201(21): 274-276, 1978.
20. Piercey, M.F., G.D. Vogelsang, S.R. Franklin, and A.H. Tang. Reversal of scopolamine-induced amnesia and alterations in energy metabolism by the nootropic piracetam: implications regarding identification of brain structures involved in consolidation of memory traces. Brain Res. 424: 1-9, 1987.
21. Liu, J. and A. Mori. Antioxidant and pre-oxidant activities of p-hydroxybenzyl alcohol and vanillin : Effects of free radicals, brain peroxidation and degradation of benzoate, deoxyribose, amino acid and DMA. Neuropharmacology 32: 659-669, 1993.
22. Cleary, J., J.M. Hittner, M. Semotuk, P. Mantyh, and E. O'Hare. Beta-amyloid (1-40) effects on behavior and memory. Brain Res. 682: 69-74, 1995.
23. Wetzel, W., T. Ott, H.K. Matthies, and H. Matthies. Effect of the memory-improving substance methylglucamine orotata on paradoxical sleep in rats. Psychopharmacology 83: 380-383, 1984.
24. Steinbusch, H.W.M. Serotonin-immunoreactive neurons and their projections in the CNS. In: Handbook of chemical neuroanatomy, edited by A. Bjorklund, T. Hokfelt, and M.J. Kuhar. Elseiver, Amsterdam, 1984, vol. 3, pp. 68-125.
25. Robinson, S.E., D. Malthe-Srensson, P.L. Wood, and J. Commissiong, Dopaminergic control of the septohippocampal cholinergic pathway. J. Pharmacol. Exp. Ther. 208: 476-479, 1979.
26. Maura, G., E. Fedele, and M. Raiteri. Acetylcholine release from hippocampal slices is modulated by 5-hydroxytryptamine. Eur. J. Pharmacol. 165: 173-179, 1989.
27. Riekkinen P.Jr. 5-HT1A and muscarinic acetylcholine receptors jointly regulate inhibitory avoidance behavior. Eur. J. Pharmacol. 262: 77-90, 1994.
28. Levin, E.D.. S.R. McGurk, J.E. Rose, and L.L. Butcher. Cholinergic-dopaminergic interactions in cognitive performance. Behav. Neural Biol. 54: 271-299, 1990.
29. Gouliaev, A.H. and A. Senning. Piracetam and other structurally related nootropics. Brain Res. Rev. 19: 180-222, 1994.
30. Matsuno, K., T. Senda, K. Matsunaga, S. Mita, and H. Kaneto. Similar ameliorating effects of benzomorphans and 5-HT2 antagonists on drug-induced impairment of passive response in mice: comparison with acetylcholinesterase inhibitors. Psychopharmacology 112: 134-141, 1993.
31. Huang, P. and C.S. Shin. Effects of Gastrodia elata Bl on the concentration and release of dopamine in rat brain. Kweichow Medica 17(1): 14-15, 1993.