Metformin interacts with physical training decreasing glycemia and increasing glycogen supply in diabetic rats;Metformina interage com o treinamento físico diminuindo a glicemia e aumentando o armazenamento de glicogênio em ratos diabéticos

Revista Brasileira de Medicina do Esporte

Volumn 14, Issue 4, 2008, Pages 337-340

  Da Silva Costa, Eunice Cristina ^a   Goncalves, Antonio Ari ^a   Brito, Isaura Jaqueline Lima ^a   Da Silva, Carlos Alberto ^b  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b METHODIST UNIVERSITY OF PIRACICABA   (Brazil)

Author keywords

Glycogen; Metformin; Training

Indexed keywords

EID: 53049099029     PISSN: 15178692     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1517-86922008000400003     Document Type: Article

References (22)

1. Petersen KF, Shulman GI. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am J Cardiol 2002;90:11G-8G.
2. Corigliano G, Lazzeta N, Corigliano M, Strollo F. Blood glucose changes in diabetic children and adolescents engaged in most common sports activities. Acta Biomed 2006;77:S26-33.
3. Levetan C. Oral antidiabetic agents in type 2 diabetes. Curr Med Res Opin 2007;23:945-52.
4. Da Silva CA, Goncalves AA. Metformin restores the hepatic stores in aloxan diabetic rats. In Tematic Module: Liver Metabolism, IX Ann Meet of Brazilian Federation of Experimental Biology Soc. August 1994, Caxambu, MG, Brazil, p. XCIII.
5. Da Silva CA, Goncalves AA. Partial recovery of erythrocyte glycogen in diabetic rats treated with phenobarbital. Braz J Med Biol Res 1997;30:657.61.
6. Krentz AJ, Bailey CJ. Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 2005;65:385-411.
7. Marchetti P, Del Guerra S, Marselli L, Lupi R, Masini M, Pollera M, et al. Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin. J Clin Endocrinol Metab 2004;89:5535.41.
8. Giannarelli R, Aragona M, Coppelli A, Del Parato S. Reducing insulin resistance with metformin: the evidence today. Diabetes Metab 2003;29:6S28-35.
9. Arkinstall MJ, Bruce CR, Clark SA, Rickards CA, Burke LM, Hawley JA. Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity. J Appl Physiol 2004;97:2275.83.
10. Koyama Y, Coker RH, Denny JC, Lacy DP, Jabbour K, Williams PE, et al. Role of carotid bodies in control of the neuroendocrine response to exercise. Am J Physiol Endocrinol Metab 2001;281:E742-8.
11. Ostergard T, Jessen N, Schmitz O, Mandarino LJ. The effect of exercise, training, and inactivity on insulin sensitivity in diabetics and their relatives: what is new? Appl Physiol Nutr Metab 2007;32:541-8.
12. Ostman-Smith I. Adaptative changes in the simpathetic nervous system an some effector organs of the rat following long term exercise or cold acclimation and the role of cardiac simpathetic nerves in the genesis of compensatory cardiac hypertrophy. Acta Physiol Scand 1979;47:S1-40.
13. Lippincott WW. American College of Sports Medicine. ACSM's Guidelines for Exercise Testing and Prescription. 6th ed. 2000. Baltimore, MD.
14. Lo Siu JCR, Russeau JC, Taylor AW. Determination of glycogen in small tissue samples. J Appl Physiol 1970;28:234-46.
15. Trinder R. Determination of glucose in blood using glucose oxidase with alternative oxygen acceptor. Ann Clin Biochem 1969;6:24.
16. Herbert V, Lau KS, Gottlieb CW, Bleicher SJ. Coated charcoal immunoassay of insulin. J Clin Endocrinol Metab 1965;25:1375-84.
17. Carvalheira JBC, Zecchin HG, Saad MJA. Vias de sinalizacao da insulina. Arq Bras Endocrinol Metab 2002;46:419-25.
18. Sigal RJ, Kenny GP, Wasserman DH, Castaneda-Sceppa C. Physical activity/exercise and type 2 diabetes. Diabetes Care 2004;27:2518-39.
19. McGee SL, Hargreaves M. Exercise and skeletal muscle glucose transporter 4 expression: molecular mechanisms. Clin Exp. Pharmacol Physiol 2006;33:395-9.
20. Song XM, Kawano Y, Krook A, Ryder JW, Efendic S, Roth RA, et al. Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes 1999;48:664-70.
21. Luciano E. Atividade fisica e metabolismo lipidico em ratos diabeticos experimentais. Revista Brasileira de Atividade Fisica e Saude 1996;1:19-26.
22. Karlsson HK, Hallsten K, Bjornholm M, Tsuchida H, Chibalin AV, Virtanen KA, et al Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study. Diabetes 2005;54:1459-67.