Litebamine, a phenanthrene alkaloid from the wood of Litsea cubeba, inhibits rat smooth muscle cell adhesion and migration on collagen

European Journal of Pharmacology

Volumn 596, Issue 1-3, 2008, Pages 25-31

  Huang, Chi Hung ^a   Huang, Wei Jan ^b   Wang, Su Jane ^c   Wu, Pi Hui ^c   Wu, Wen Bin ^c  

^a CATHAY GENERAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Adhesion; Alkaloid; Cardiovascular disease; Litebamine; Migration; Natural compound; PDGF; Smooth muscle cell

Indexed keywords

ACTIN; ANTICOAGULANT AGENT; COLLAGEN; CYTOSKELETON PROTEIN; FOCAL ADHESION KINASE; LITEBAMINE; MATRIX METALLOPROTEINASE; PHENANTHRENE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL ADHESION; CELL MIGRATION; CELL SECRETION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; LITSEA; LITSEA CUBEBA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RESTENOSIS; SMOOTH MUSCLE; THROMBOCYTE AGGREGATION INHIBITION; WOOD;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL ADHESION; CELL MOVEMENT; CELLS, CULTURED; COLLAGEN; ENZYME ACTIVATION; FOCAL ADHESION KINASE 1; ISOQUINOLINES; LITSEA; MATRIX METALLOPROTEINASES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PHENANTHRENES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION;

EID: 53049092436     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.08.013     Document Type: Article

References (24)

1. Aplin A.E., Howe A., Alahari S.K., and Juliano R.L. . Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol. Rev. 50 (1998) 197-264
2. Calderwood D.A., Shattil S.J., and Ginsberg M.H. Integrins and actin filaments: reciprocal regulation of cell adhesion and signaling. J. Biol. Chem. 275 (2000) 22607-22610
3. Chen W.Y., Ko F.N., Wu Y.C., Lu S.T., and Teng C.M. Vasorelaxing effect in rat thoracic aorta caused by laurotetanine isolated from Litsea cubeba Persoon. J. Pharm. Pharmacol. 46 (1994) 380-382
4. Cheng X.W., Kuzuya M., Nakamura K., Liu Z., Di Q., Hasegawa J., Iwata M., Murohara T., Yokota M., and Iguchi A. Mechanisms of the inhibitory effect of epigallocatechin-3-gallate on cultured human vascular smooth muscle cell invasion. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1864-1870
5. Chiou C.M., Kang J.J., and Lee S.S. Litebamine N-homologues: preparation and anti-acetylcholinesterase activity. J. Nat. Prod. 61 (1998) 46-50
6. Evanko S.P., Raines E.W., Ross R., Gold L.I., and Wight T.N. Proteoglycan distribution in lesions of atherosclerosis depends on lesion severity, structural characteristics, and the proximity of platelet-derived growth factor and transforming growth factor-beta. Am. J. Pathol. 152 (1998) 533-546
7. Hughes A.D., Clunn G.F., Refson J., and moliou-Mason C. Platelet-derived growth factor (PDGF): actions and mechanisms in vascular smooth muscle. Gen. Pharmacol.: The Vascular System 27 (1996) 1079-1089
8. Hung C.F., Huang T.F., Chiang H.S., and Wu W.B. (-)-Epigallocatechin-3-gallate, a polyphenolic compound from green tea, inhibits fibroblast adhesion and migration through multiple mechanisms. J. Cell. Biochem. 96 (2005) 183-197
9. Iijima K., Yoshizumi M., Hashimoto M., Akishita M., Kozaki K., Ako J., Watanabe T., Ohike Y., Son B., Yu J., Nakahara K., and Ouchi Y. Red wine polyphenols inhibit vascular smooth muscle cell migration through two distinct signaling pathways. Circulation 105 (2002) 2404-2410
10. Lo H.M., Hung C.F., Huang Y.Y., and Wu W.B. Tea polyphenols inhibit rat vascular smooth muscle cell adhesion and migration on collagen and laminin via interference with cell-ECM interaction. J. Biomed. Sci. 14 (2007) 637-645
11. Lo H.M., Hung C.F., Tseng Y.L., Chen B.H., Jian J.S., and Wu W.B. Lycopene binds PDGF-BB and inhibits PDGF-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem. Pharmacol. 74 (2007) 54-63
12. Maeda K., Kuzuya M., Cheng X.W., Asai T., Kanda S., Tamaya-Mori N., Sasaki T., Shibata T., and Iguchi A. Green tea catechins inhibit the cultured smooth muscle cell invasion through the basement barrier. Atherosclerosis 166 (2003) 23-30
13. Moiseeva E.P. Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovas. Res. 52 (2001) 372-386
14. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 116 (2003) 1409-1416
15. Plow E.F., Haas T.A., Zhang L., Loftus J., and Smith J.W. Ligand binding to integrins. J. Biol. Chem. 275 (2000) 21785-21788
16. Raines E.W., Koyama H.I.D.E., and Carragher N.O. The extracellular matrix dynamically regulates smooth muscle cell responsiveness to PDGF. Ann. N.Y. Acad. Sci. 902 (2000) 39-52
17. Ross R. Cell biology of atherosclerosis. Ann. Rev. Physiol. 57 (1995) 791-804
18. Rubin K., Tingstrom A., Hansson G.K., Larsson E., Ronnstrand L., Klareskog L., Claesson-Welsh L., Heldin C.H., Fellström B., and Terracio L. Induction of B-type receptors for platelet-derived growth factor in vascular inflammation: possible implications for development of vascular proliferative lesions. Lancet. 1 (1998) 1353-1356
19. Tallquist M., and Kazlauskas A. PDGF signaling in cells and mice. Cyto. Growth Factor Rev. 15 (2004) 205-213
20. Teng C.M., Hsueh C.M., Chang Y.L., Ko F.N., Lee S.S., and Liu K.C. Antiplatelet effects of some aporphine and phenanthrene alkaloids in rabbits and man. J. Pharm. Pharmacol. 49 (1997) 706-711
21. Wang C.Y. The active principles of Litsea cubeba in the treatment of coronary heart disease. Zhong Yao Tong Bao. 10 (1985) 30-32
22. Weber A.A., Neuhaus T., Skach R.A., Hescheler J., Ahn H.Y., Schror K., Ko Y., and Sachinidis A. Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis. FASEB. J. 18 (2004) 128-130
23. Wu Y.C., Liou J.Y., Duh C.Y., Lee S.S., and Lu S.T. Litebamine, a novel phenanthrene alkaloid from Litsea cubeba. Tetrahedron Lett. 32 (1991) 4169-4170
24. Yao J.S., Chen Y., Zhai W., Xu K., Young W.L., and Yang G.Y. Minocycline exerts multiple inhibitory effects on vascular endothelial growth factor-induced smooth muscle cell migration: the role of ERK1/2, PI3K, and matrix metalloproteinases. Circ. Res. 95 (2004) 364-371