The extracellular matrix dynamically regulates smooth muscle cell responsiveness to PDGF

Annals of the New York Academy of Sciences

Volumn 902, Issue , 2000, Pages 39-52

  Raines, Elaine W ^a,b   Koyama, Hidenori ^a,c   Carragher, Neil O ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; FIBRONECTIN; INTEGRIN; PLATELET DERIVED GROWTH FACTOR;

ARTERY MEDIA; ATHEROGENESIS; ATHEROSCLEROSIS; CELL CULTURE; CELL MIGRATION; CELL PROLIFERATION; CONFERENCE PAPER; CYTOSKELETON; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; PHENOTYPE; PROTEIN ASSEMBLY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE;

EID: 0034081950     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06299.x     Document Type: Conference Paper

References (84)

1. 1. Ross, R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362: 801-809.
2. 2. Ross, R. 1999. Atherosclerosis - an inflammatory disease. N. Engl. J. Med. 340: 115-126.
3. 3. Ross, R., J. MASUDA, E.W. RAINES, A.M. GOWN, S. KATSUDA, M. SASAHARA, L.T. MALDEN, H. MASUKO & H. SATO. 1990. Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science 248: 1009-1012.
4. 4. FERNS, G.A., E.W. RAINES, K.H. SPRUGEL, A.S. MOTANI, M.A. REIDY & R. Ross. 1991. Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF. Science 253: 1129-1132.
5. 5. KOYAMA, H., E.W. RAINES, K.E. BORNFELDT, J.M. ROBERTS & R. Ross. 1996. Fibrillar collagen inhibits arterial smooth muscle proliferation through regulation of Cdk2 inhibitors. Cell 87: 1069-1078.
6. 6. CAMPBELL G.R. & J.H. CAMPBELL. 1990. The phenotypes of smooth muscle expressed in human atheroma. Ann. N.Y. Acad. Sci. 598: 143-158.
7. 7. THYBERG, J., U. HEDIN, M. SJÖLUND, L. PALMBERG & B.A. BOTTGER. 1990. Regulation of differentiated properties and proliferation of arterial smooth muscle cells. Arteriosclerosis 10: 966-990.
8. 8. GABBIANI, G., O. KOCHER, W.S. BLOOM, J. VANDEKERCKHOVE & K. WEBER. 1984. Actin expression in smooth muscle cells of rat aortic intimal thickening, human atheromatous plaque, and cultured rat aortic media. J. Clin. Invest. 73: 148-152.
9. 9. GLUKHOVA, M.A., A.E. KABAKOV, M.G. FRID, O.I. ORNATSKY, A.M. BELKIN, D.N. MUKHIN, A.N. OREKHOV, V.E. KOTELIANSKY & V.N. SMIRNOV. 1988. Modulation of human aorta smooth muscle cell phenotype: a study of muscle-specific variants of vinculin, caldesmon, and actin expression. Proc. Natl. Acad. Sci. USA 85: 9542-9546.
10. 10. AIKAWA, M., P.M. SIVAM, M. KURO-O, K. KIMURA, K. NAKAHARA, S. TAKEWAKI, M. UEDA, H. YAMAGUCHI, Y. YAZAKI, M. PERIASAMY & R. NAGAI. 1993. Human smooth muscle myosin heavy chain isoforms as molecular markers for vascular development and atherosclerosis. Circ. Res. 73: 1000-1012.
11. 11. UEKI, N., K. SOBUE, K. KANDA, T. HADA & K. HIGASHINO. 1987. Expression of high and low molecular weight caldesmons during phenotypic modulation of smooth muscle cells. Proc. Natl. Acad. Sci. USA 84: 9049-9053.
12. 12. RECKLESS, J., G. FLEETWOOD, L. TILLING, P.A. HUBER, S.B. MARSTON & K. PRITCHARD. 1994. Changes in the caldesmon isoform content and intimal thickening in the rabbit carotid artery induced by a silicone elastomer collar. Arterioscler. Thromb. 14: 1837-1845.
13. 13. KOCHER, O. & G. GABBIANI. 1986. Cytoskeletal features of normal and atheromatous human arterial smooth muscle cells. Hum. Pathol. 17: 875-880.
14. 14. OSBORN, M., J. CASELITZ, K. PUSCHEL & K. WEBER. 1987. Intermediate filament expression in human vascular smooth muscle and in arteriosclerotic plaques. Virchows Arch. A Pathol. Anat. Histopathol. 411: 449-458.
15. 15. KURO-O, M., R. NAGAI, K. NAKAHARA, H. KATOH, R.C. TSAI, H. TSUCHIMOCHI, Y. YAZAKI, A. OHKUBO & F. TAKAKU. 1991. cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis. J. Biol. Chem. 266: 3768-3773.
16. 16. GALLAGHER, P.J., J.G. GARCIA & B.P. HERRING. 1995. Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells. J. Biol. Chem. 270: 29090-29095.
17. 17. FISHER, S.A. & M. IKEBE. 1995. Developmental and tissue distribution of expression of nonmuscle and smooth muscle isoforms of myosin light chain kinase. Biochem. Biophys. Res. Commun. 217: 696-703.
18. 18. GALLAGHER, P.J., Y. JIN & V. LINDNER. 1998. Expression of myosin and myosin light chain kinase in response to vascular injury [abstract]. Presented at Keystone Symposium on Angiogenesis and Vascular Remodeling. Steamboat Springs, CO. No. 312.
19. 19. SHANAHAN, C.M., N.R. CARY, J.C. METCALFE & P.L. WEISSBERG. 1994. High expression of genes for calcification-regulating proteins in human atherosclerotic plaques. J. Clin. Invest. 93: 2393-2402.
20. 20. KOCHER, O., F. GABBIANI, G. GABBIANI, M.A. REIDY, M.S. COKAY, H. PETERS & I. HUTTNER. 1991. Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Lab. Invest. 65: 459-470.
21. 21. MEYER, T., U. BRINK, C. UNTERBERG, S. STOHR, H. KREUZER & A.B. BUCHWALD. 1994. Expression of meta-vinculin in human coronary arteriosclerosis is related to the histological grade of plaque formation. Atherosclerosis 111: 111-119.
22. 22. MCCULLAGH, K.G., V.C. DUANCE & K.A. BISHOP. 1980. The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta. J. Pathol. 130: 45-55.
23. 23. Voss, B. & J. RAUTERBERG. 1986. Localization of collagen types I, III, IV and V, fibronectin and laminin in human arteries by the indirect immunofluorescence method. Pathol. Res. Pract. 181: 568-575.
24. 24. KATSUDA, S., Y. OKADA, T. MINAMOTO, Y. ODA, Y. MATSUI & I. NAKANISHI. 1992. Collagens in human atherosclerosis. Immunohistochemical analysis using collagen type-specific antibodies. Arterioscler. Thromb. 12: 494-502.
25. 25. WEITKAMP, B., P. CULLEN, G. PLENZ, H. ROBENEK & J. RAUTERBERG. 1999. Human macrophages synthesize type VIII collagen in vitro and in the atherosclerotic plaque. FASEB J. 13: 1445-1457.
26. 26. KAKOLYRIS, S., P. KARAKITSOS, M. TZARDI & E. AGAPITOS. 1995. Immunohistochemical detection of fibronectin in early and advanced atherosclerosis. In Vivo 9: 35-40.
27. 27. THYBERG, J., K. BLOMGREN, J. ROY, P.K. TRAN & U. HEDIN. 1997. Phenotypic modulation of smooth muscle cells after arterial injury is associated with changes in the distribution of laminin and fibronectin. J. Histochem. Cytochem. 45: 837-846.
28. 28. STENMAN, S., K. VON SMITTEN & A. VAHERI. 1980. Fibronectin and atherosclerosis. Acta Med. Scand. Suppl. 642: 165-170.
29. 29. GIACHELLI, C.M., N. BAE, M. ALMEIDA, D.T. DENHARDT, C.E. ALPERS & S.M. SCHWARTZ. 1993. Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques. J. Clin. Invest. 92: 1686-1696.
30. 30. IKEDA, T., T. SHIRASAWA, Y. ESAKI, S. YOSHIKI & K. HIROKAWA. 1993. Osteopontin mRNA is expressed by smooth muscle-derived foam cells in human atherosclerotic lesions of the aorta. J. Clin. Invest. 92: 2814-2820.
31. 31. RAINES, E.W., T.F. LANE, M.L. IRUELA-ARISPE, R. Ross & E.H. SAGE. 1992. The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc. Natl. Acad. Sci. USA 89: 1281-1285.
32. 32. WALLNER, K., C. LI, P.K. SHAH, M.C. FISHBEIN, J.S. FORRESTER, S. KAUL & B.G. SHARIFI. 1999. Tenascin-C is expressed in macrophage-rich human coronary atherosclerotic plaque. Circulation 99: 1284-1289.
33. 33. WIGHT, T.N., G.J. RAUGI, S.M. MUMBY & P. BORNSTEIN. 1985. Light microscopic immunolocation of thrombospondin in human tissues. J. Histochem. Cytochem. 33: 295-302.
34. 34. NICULESCU, F., H.G. Rus & R. VLAICU. 1987. Immunohistochemical localization of C5b-9, S-protein, C3d and apolipoprotein B in human arterial tissues with atherosclerosis. Atherosclerosis 65: 1-11.
35. 35. DUFOURCQ, P., H. Louis, C. MOREAU, D. DARET, M.R. BOISSEAU, J.M. LAMAZIERE & J. BONNET. 1998. Vitronectin expression and interaction with receptors in smooth muscle cells from human atheromatous plaque. Arterioscler. Thromb. Vasc. Biol. 18: 168-176.
36. 36. VAN AKEN, B.E., D. SEIFFERT, T. THINNES & D.J. LOSKUTOFF. 1997. Localization of vitronectin in the normal and atherosclerotic human vessel wall. Histochem. Cell Biol. 107: 313-320.
37. 37. GALIS, Z.S., G.K. SUKHOVA, M.W. LARK & P. LIBBY. 1994. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J. Clin. Invest. 94: 2493-2503.
38. 38. NIKKARI, S.T., K.D. O'BRIEN, M. FERGUSON, T. HATSUKAMI, H.G. WELGUS, C.E. ALPERS & A.W. CLOWES. 1995. Interstitial collagenase (MMP-1) expression in human carotid atherosclerosis. Circulation 92: 1393-1398.
39. 39. BROWN, D.L., M.S. HIBBS, M. KEARNEY, C. LOUSHIN & J.M. ISNER. 1995. Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation 91: 2125-2131.
40. 40. CURCI, J.A., S. LIAO, M.D. HUFFMAN, S.D. SHAPIRO & R.W. THOMPSON. 1998. Expression and localization of macrophage elastase (matrix metalloproteinase-12) in abdominal aortic aneurysms. J. Clin. Invest. 102: 1900-1910.
41. 41. SUKHOVA, G.K., U. SCHONBECK, E. RABKIN, F.J. SCHOEN, A.R. POOLE, R.C. BILLING-HURST & P. LIBBY. 1999. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation 99: 2503-2509.
42. 42. SCHONBECK, U., F. MACH, G.K. SUKHOVA, E. ATKINSON, E. LEVESQUE, M. HERMAN, P. GRABER, P. BASSET & P. LIBBY. 1999. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro. J. Exp. Med. 189: 843-853.
43. 43. RAJAVASHISTH, T.B., X.P. Xu, S. JOVINGE, S. MEISEL, X.O. Xu, N.N. CHAI, M.C. FISHBEIN, S. KAUL, B. CERCEK, B. SHARIFI & P.K. SHAH. 1999. Membrane type 1 matrix metalloproteinase expression in human atherosclerotic plaques: evidence for activation by proinflammatory mediators. Circulation 99: 3103-3109.
44. 44. FABUNMI, R.P., G.K. SUKHOVA, S. SUGIYAMA & P. LIBBY. 1998. Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: a potential protective mechanism in plaque stability. Circ. Res. 83: 270-278.
45. 45. NIKKARI, S.T., R.L. GEARY, T. HATSUKAMI, M. FERGUSON, R. FOROUGH, C.E. ALPERS & A.W. CLOWES. 1996. Expression of collagen, interstitial collagenase, and tissue inhibitor of metalloproteinases-1 in restenosis after carotid endarterectomy. Am. J. Pathol. 148: 777-783.
46. 46. SCHNEIDERMAN, J., M.S. SAWDEY, M.R. KEETON, G.M. BORDIN, E.F. BERNSTEIN, R.B. DILLEY & D.J. LOSKUTOFF. 1992. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc. Natl. Acad. Sci. USA 89: 6998-7002.
47. 47. TIPPING, P.G., P. DAVENPORT, M. GALLICCHIO, E.L. FILONZI, J. APOSTOLOPOULOS & J. WOJTA. 1993. Atheromatous plaque macrophages produce plasminogen activator inhibitor type-1 and stimulate its production by endothelial cells and vascular smooth muscle cells. Am. J. Pathol. 143: 875-885.
48. 48. LUPU, F., G.E. BERGONZELLI, D.A. HEIM, E. COUSIN, C.Y. GENTON, F. BACHMANN & E.K. KRUITHOF. 1993. Localization and production of plasminogen activator inhibitor-1 in human healthy and atherosclerotic arteries. Arterioscler. Thromb. 13: 1090-1000.
49. 49. PADRO, T., J.J. EMEIS, M. STEINS, K.W. SCHMID & J. KIENAST. 1995. Quantification of plasminogen activators and their inhibitors in the aortic vessel wall in relation to the presence and severity of atherosclerotic disease. Arterioscler. Thromb. Vasc. Biol. 15: 893-902.
50. 50. RAGHUNATH, P.N., J.E. TOMASZEWSKI, S.T. BRADY, R.J. CARON, S.S. OKADA & E.S. BARNATHAN. 1995. Plasminogen activator system in human coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15: 1432-1443.
51. 51. LUPU, F., D.A. HEIM, F. BACHMANN, M. HURNI, V.V. KAKKAR & E.K. KRUITHOF. 1995. Plasminogen activator expression in human atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 15: 1444-1455.
52. 52. ROBBIE, L.A., N.A. BOOTH, A.J. BROWN & B. BENNETT. 1996. Inhibitors of fibrinolysis are elevated in atherosclerotic plaque. Arterioscler. Thromb. Vasc. Biol. 16: 539-545.
53. 53. REKHTER, M.D. & D. GORDON. 1995. Active proliferation of different cell types, including lymphocytes, in human atherosclerotic plaques. Am. J. Pathol. 147: 668-677.
54. 54. HEDIN, U., B.A. BOTTGER, E. FORSBERG, S. JOHANSSON & J. THYBERG. 1988. Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells. J. Cell Biol. 107: 307-319.
55. 55. SAGE, E.H. & P. BORNSTEIN. 1991. Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin. J. Biol. Chem. 266: 14831-14834.
56. 56. LIAW, L., M.P. SKINNER, E.W. RAINES, R. Ross, D.A. CHERESH, S.M. SCHWARTZ & C.M. GIACHELLI. 1995. The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro. J. CHn. Invest. 95: 713-724.
57. 57. SLEPIAN, M.J., S.P. MASSIA, B. DEHDASHTI, A. FRITZ & L. WHITESELL. 1998. Beta3-integrins rather than beta 1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration. Circulation 97: 1818-1827.
58. 58. SCHOR, S.L. 1980. Cell proliferation and migration on collagen substrata in vitro. J. Cell Sci. 41: 159-175.
59. 59. RHUDY, R.W. & J.M. MCPHERSON. 1988. Influence of the extracellular matrix on the proliferative response of human skin fibroblasts to serum and purified platelet-derived growth factor. J. Cell. Physiol. 137: 185-191.
60. 60. MARTIN, G.M. & A.C. SANK. 1990. Extracellular matrices, cells, and growth factors. In Peptide Growth Factors and Their Receptors II. M.B. Sporn & A.B. Roberts, Eds. Springer Verlag. Berlin.
61. 61. REKHTER, M.D. & D. GORDON. 1994. Cell proliferation and collagen synthesis are two independent events in human atherosclerotic plaques. J. Vasc. Res. 31: 280-286.
62. 62. HULTGARDH-NlLSSON, A., C. LOVDAHL, K. BLOMGREN, B. KALLIN & J. THYBERG. 1997. Expression of phenotype-and proliferation-related genes in rat aortic smooth muscle cells in primary culture. Cardiovasc. Res. 34: 418-430.
63. 63. VANE, J.R., E.E. ANGGARD & R.M. BOTTING. 1990. Regulatory functions of the vascular endothelium. N. Engl. J. Med. 323: 27-36.
64. 64. HIROSE, M., H. KOSUGI, K. NAKAZATO & T. HAYASHI. 1999. Restoration to a quiescent and contractile phenotype from a proliferative phenotype of myofibroblast-like human aortic smooth muscle cells by culture on type IV collagen gels. J. Biochem. (Tokyo) 125: 991-1000.
65. 65. SHERR, C.J. 1993. Mammalian G1 cyclins. Cell 73: 1059-1065.
66. 66. APRELIKOVA, O., Y. XIONG & E.T. LIU. 1995. Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase. J. Biol. Chem. 270: 18195-18197.
67. 67. SHERR, C.J. & J.M. ROBERTS. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9: 1149-1163.
68. 68. VOGEL, W., G.D. GISH, F. ALVES & T. PAWSON. 1997. The discoidin domain receptor tyrosine kinases are activated by collagen. Molec. Cell 1: 13-23.
69. 69. SHRIVASTAVA, A., C. RADZIEJEWSKI, E. CAMPBELL, L. KOVAC, M. MCGLYNN, T.E. RYAN, S. DAVIS, M.P. GOLDFARB, D.J. GLASS, G. LEMKE & G.D. YANCOPOULOS. 1997. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Molec. Cell 1: 25-34
70. 70. SCHLESSINGER, J. 1997. Direct binding and activation of receptor tyrosine kinases by collagen. Cell 91: 869-872.
71. 71. VOGEL, W. 1999. Discoidin domain receptors: structural relations and functional implications. FASEB J. 13: S77-82.
72. 72. FOLKMAN J. & A. MOSCONA. 1978. Role of cell shape in growth control. Nature 273: 345-349.
73. 73. HANSEN, L.K., D.J. MOONEY, J.P. VACANTI & D.E. INGBER. 1994. Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth. Mol. Biol. Cell 5: 967-975.
74. 74. FANG, F., G. OREND, N. WATANABE, T. HUNTER & E. RUOSLAHTI. 1996. Dependence of cyclin E-cdk2 kinase activity on cell anchorage. Science 271: 499-502.
75. 75. ZHU, S., M. OHTSUBO, R. BOHMER, J.M. ROBERTS & R.K. ASSOIAN. 1996. Adhesion dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein. J. Cell Biol. 133: 391-403.
76. Kip1 as the common target of integrin-mediated signals. Submitted for publication.
77. 77. MERCURIUS, K.O. & A.O. MORLA. 1998. Inhibition of vascular smooth muscle cell growth by inhibition of fibronectin matrix assembly. Circ. Res. 82: 548-556.
78. 78. TANNER, F.C., Z.Y. YANG, E. DUCKERS, D. GORDON, G.J. NABEL & E.G. NABEL. 1998. Expression of cyclin-dependent kinase inhibitors in vascular disease. Circ. Res. 82: 396-403.
79. 79. DAVIS, G.E. 1992. Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sites. Biochem. Biophys. Res. Commun. 182: 1025-1031.
80. 80. MONTGOMERY, A.M., R.A. REISFELD & D.A. CHERESH. 1994. Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl. Acad. Sci. USA 91: 8856-8860.
81. 81. MESSENT, A.J., D.S. TUCKWELL, V. KNAUPER, M.J. HUMPHRIES, G. MURPHY & J. GAVRILOVIC. 1998. Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion. J. Cell Sci. 111: 1127-1135.
82. 82. JONES, P.L., J. CRACK & M. RABINOVITCH. 1997. Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J. Cell Biol. 139: 279-293.
83. FAK , paxillin, and talin. J. Cell Biol. 147: 619-629.
84. 84. CHANG, M.Y., S. SASAHARA, A. CHAIT, E.W. RAINES & R. Ross. 1995. Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation. Arterioscler. Thromb. Vasc. Biol. 15: 1631-1640.