A dual receptor crosstalk model of G-protein-coupled signal transduction

PLoS Computational Biology

Volumn 4, Issue 9, 2008, Pages

  Flaherty, Patrick ^a   Radhakrishnan, Mala L ^b   Dinh, Tuan ^c   Rebres, Robert A ^d   Roach, Tamara I ^d   Jordan, Michael I ^e   Arkin, Adam P ^a,c,f  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c University of California at Berkeley   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOPHAGES; CELL SIGNALING; CROSSTALK; DESIGN OF EXPERIMENTS; GENE EXPRESSION; LIGANDS; MACROPHAGES; PHYSIOLOGY; PROTEINS; SIGNAL TRANSDUCTION; SIGNALING;

CELL MORPHOLOGY; CROSSTALK MODELS; DIPHOSPHATES; G PROTEIN; G PROTEIN COUPLED RECEPTORS; GENES EXPRESSION; ION HOMEOSTASIS; MACROPHAGE CELLS; PHYSIOLOGICAL STATE; RECEPTOR SYSTEM;

CALCIUM;

CALCIUM ION; COMPLEMENT COMPONENT C5A; G PROTEIN COUPLED RECEPTOR; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; PURINERGIC P2Y RECEPTOR; SHORT HAIRPIN RNA; URIDINE DIPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; LENTIVIRINAE; LIGAND BINDING; MACROPHAGE; MODEL; MONTE CARLO METHOD; MOUSE; NONHUMAN; PREDICTION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; CALCIUM SIGNALING; CELL LINE; DRUG ANTAGONISM; FEEDBACK SYSTEM; GENETICS; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

ANIMALS; CALCIUM SIGNALING; CELL LINE; COMPLEMENT C5A; COMPUTATIONAL BIOLOGY; FEEDBACK, BIOCHEMICAL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; LIGANDS; MACROPHAGES; MICE; MODELS, BIOLOGICAL; RECEPTOR CROSS-TALK; RECEPTORS, G-PROTEIN-COUPLED; RNA INTERFERENCE; SIGNAL TRANSDUCTION; URIDINE DIPHOSPHATE;

EID: 52949139072     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000185     Document Type: Article

References (46)

1. Kroeze WK, Sheffler DJ, Roth BL (2003) G-protein-coupled receptors at a glance. J Cell Sci 116: 4867-4869.
2. 2+. Biochem J 374: 281-296.
3. Casey PJ, Gilman AG (1988) G protein involvement in receptor-effector coupling. J Biol Chem 263: 2577-2580.
4. 2 by the α and βγ subunits of trimeric GTP-binding protein. Proc Natl Acad Sci U S A 90: 5297-5301.
5. q promoted by receptor and GTPase-activating proteins. Proc Natl Acad Sci U S A 96: 9539-9544.
6. Patterson RL, Boehning D, Snyder SH (2004) Inositol 1,4,5-trisphosphate receptors as signal integrators. Annu Rev Biochem 73: 437-465.
7. Ananthanarayanan B, Stahelin RV, Digman MA, Cho W (2003) Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains. J Biol Chem 278: 46886-46894.
8. Penela P, Ribas C, Mayor F Jr (2003) Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases. Cell Signal 15: 973-981.
9. βγ subunits and lipid. J Biol Chem 270: 11707-11710.
10. Berg JM, Tymoczko JL, Stryer L (2002) Biochemistry. 5th ed. Bethesda (Maryland): W.H. Freeman; National Center for Biotechnology Information.
11. Allegretti M, Moriconi A, Beccari AR, Di Bitondo R, Bizzarri C, et al. (2005) Targeting C5a: recent advances in drug discovery. Curr Med Chem 12: 217-236.
12. 6 nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem 276: 26051-26056.
13. Yoshioka K, Saitoh O, Nakata H (2001) Heteromeric association creates a P2Y-like adenosine receptor. Proc Natl Acad Sci U S A 98: 7617-7622.
14. Lukas TJ (2004) A signal transduction pathway model prototype I: from agonist to cellular endpoint. Biophys J 87: 1406-1416.
15. 3-mediated calcium release. Biophys J 83: 1298-1316.
16. Lemon G, Gibson WG, Bennett MR (2003) Metabotropic receptor activation, desensitization and sequestration - I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. J Theor Biol 223: 93-111.
17. Maurya MR, Subramaniam S (2007) A kinetic model for calcium dynamics in RAW 264.7 cells: 2. Knockdown response and long-term response. Biophys J 93: 729-740.
18. Maurya MR, Subramaniam S (2007) A kinetic model for calcium dynamics in RAW 264.7 Cells: 1. Mechanisms, parameters and sub-populational variability. Biophys J 93: 709-728.
19. q-coupled receptors is mediated by Gβγ exchange. Proc Natl Acad Sci U S A 96: 10626-10631.
20. 16 and evidence for a synergic interaction between Gβγ and the α subunit of a receptor activated G protein. Proc Natl Acad Sci U S A 93: 2827-2831.
21. Kehrl JH (1998) Heterotrimeric G protein signaling: roles in immune function and fine-tuning by RGS proteins. Immunity 8: 1-10.
22. Ross EM, Wilkie TM (2000) GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem 69: 795-827.
23. 11 signaling. J Biol Chem 276: 5438-5444.
24. Kehrl JH, Sinnarajah S (2002) RGS2: a multifunctional regulator of G-protein signaling. Int J Biochem Cell Biol 34: 432-438.
25. 2+ oscillations. Biophys J 61: 649-660.
26. Meyer T, Holowka D, Stryer L (1988) Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate. Science 240: 653-656.
27. Meyer T, Stryer L (1988) Molecular model for receptor-stimulated calcium spiking. Proc Natl Acad Sci U S A 85: 5051-5055.
28. Jiang H, Kuang Y, Wu Y, Smrcka A, Simon MI, et al. (1996) Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. J Biol Chem 271: 13430-13434.
29. Park D, Jhon DY, Lee CW, Lee KH, Rhee SG (1993) Activation of phospholipase C isozymes by G protein βγ subunits. J Biol Chem 268: 4573-4576.
30. Smrcka AV, Sternweis PC (1993) Regulation of purified subtypes of phosphatidylinositol-specific phospholipase C β by G protein α and βγ subunits. J Biol Chem 268: 9667-9674.
31. q. J Biol Chem 269: 25335-25338.
32. Jiang H, Wu D, Simon MI (1994) Activation of phospholipase C β4 by heterotrimeric GTP-binding proteins. J Biol Chem 269: 7593-7596.
33. Runnels LW, Scarlata SF (1999) Determination of the affinities between heterotrimeric G protein subunits and their phospholipase C-β effectors. Biochemistry 38: 1488-1496.
34. Rhee SG (2001) Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70: 281-312.
35. 3 by protein kinase C. J Biol Chem 275: 30220-30225.
36. Litosch I (2002) Novel mechanisms for feedback regulation of phospholipase C-β activity. IUBMB Life 54: 253-260.
37. Spitaler M, Cantrell DA (2004) Protein kinase C and beyond. Nat Immunol 5: 785-790.
38. Langkabel P, Zwirner J, Oppermann M (1999) Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by G protein-coupled receptor kinases. Eur J Immunol 29: 3035-3046.
39. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, et al. (2006) A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A 103: 13759-13764.
40. Natarajan M, Lin KM, Hsueh RC, Sternweis PC, Ranganathan R (2006) A global analysis of cross-talk in a mammalian cellular signalling network. Nat Cell Biol 8: 571-580.
41. 2+ concentration. Proc Natl Acad Sci U S A 89: 9895-9899.
42. Hindmarsh AC, Brown PN, Grant KE, Lee SL, Serban R, et al. (2005) SUNDIALS: Suite of Nonlinear and Differential/Algebraic Equation Solvers. ACM Trans Math Softw 31: 363-396.
43. Tsien RY (1989) Fluorescent indicators of ion concentrations. Methods Cell Biol 30: 127-156.
44. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450.
45. Robert CP, Casella G (2004) Monte Carlo Statistical Methods. New York: Springer.
46. Gelman A, Rubin DB (1992) Inference from iterative simulation using multiple sequences. Stat Sci 7: 457-472.