QSAR study of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors

Medicinal Chemistry Research

Volumn 17, Issue 2-7, 2008, Pages 258-266

  Soni, Love Kumar ^a   Gupta, Arun Kumar ^a   Kaskhedikar, S G ^a  

^a SHRI G S INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

2,4 Thiazolidinediones; Aldose reductase inhibitors; Diabetes mellitus; Fujita Ban analysis; Hansch analysis; QSAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETIC ACID; ALDOSE REDUCTASE INHIBITOR; CARBOXYL GROUP; OXIDOREDUCTASE;

BINDING AFFINITY; CONFERENCE PAPER; DRUG MECHANISM; ENZYME INHIBITION; HYDROPHOBICITY; MOLECULAR MODEL; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 52949120352     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-007-9061-4     Document Type: Conference Paper

References (21)

1. D Amic D Davidovic-Amic D Beslo B Lucic N Trinajstic 1997 The Use of the Ordered Orthogonalized Multivariate Linear Regression in a Structure-Activity Study of Coumarin and Flavonoid Derivatives as Inhibitors of Aldose Reductase J Chem Inform Comput Sci 37 581 586
2. CM Clarck Jr DA Lee 1995 Prevention and treatment. of the complications of Diabetes Mellitus N Engl J Med 332 1210 1217
3. L Costantino G Rastelli P Vianello G Cignarella D Barlocco 1999 Diabetes complications and their potential prevention: Aldose reductase inhibition and other approaches Med Res Rev 19 3 23
4. CS Chem Office 60 Cambridge soft corporation Software Publishers Association 1730 M Street suite 700 Washington D C 20036 (202) 452-1600 USA
5. AK Gupta BM Arockia SG Kaskhedikar 2004 VALSTAT: A Program for Quantitative Structure Activity Relationship Studies and their validations Indian J Pharm Sci 66 396 402
6. Hansch C, Leo A (1979) Substituent constants for correlation analysis in chemistry and biology. Wiley, New York, NY
7. PF Kador 1988 The role of aldose reductase in the development of diabetic complications Med Res Rev 8 325 352
8. PF Kador JH Kinoshita NJ Sharpless 1985 Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications J Med Chem 28 841 849
9. PF Kador N Sharpless 1983 Pharmacophor requirements of the aldose reductase inhibitor site J Mol Pharmacol 24 521 531
10. JH Kinoshita C Nishimura 1988 The involvement of aldose reductase in diabetic complications Diabetes Metab Rev 4 323 337
11. Kubinyi H (1993) Hansch analysis and related approaches. Weinheim, New York
12. R Maccari R Ottana C Curinga MG Vigorita D Rakowitz T Steindl T Langer 2005 Structure-activity relationships and molecular modelling of 5-arylidene-2,4-thiazolidinediones active as aldose reductase inhibitors Bioorg Med Chem 13 2809 2823
13. S Miyamoto 2002 Molecular modeling and structure-based drug discovery studies of aldose reductase inhibitors Chem-Bio Inform J 2 74 78
14. DM Nathan 1993 Long-term complications of diabetes mellitus N Engl J Med 328 1676 1685
15. A Nicolucci F Carinci D Cavaliere N Scorpiglione M Belfiglio D Labbrozzi E Mari M. G Massi Bendetti Tognoni A Liberati 1996 A meta-analysis of trials on aldose reductase inhibitors in diabetic peripheral neuropathy Diabetic Med 13 1017 1026
16. YS Prabhakar MK Gupta N Roy Y Venkateswarlu 2006 A high dimensional QSAR study on the aldose reductase inhibitory activity of some flavones: Topological descriptors in modeling the activity J Chem Inform Modeling 46 86 92
17. R Sarges PJ Oates 1993 Aldose reductase inhibitors: recent developments Prog Drug Res 40 99 161
18. LK Soni SG Kaskhedikar 2006 Exploring structural requirements for aldose-reductase inhibition by 2,4-dioxo-5-(naphthyl methylene) -3-thiazolidine acetic acids and 2-thioxo analogues: Fujita-Ban and Hansch approach Arch Pharm Chem Life Sci 339 327 331
19. A Stefanic-Petek A Krbavcic T Solmajer 2002 QSAR of flavonoids: 4. differential inhibition of aldose reductase and p56lck protein tyrosine kinase Croat Chem Acta 75 517 529
20. The Diabetic Complications, Control Trial Research Group 1993 the effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus N Engl J Med 329 977 986
21. United Kingdom Prospective Diabetes Study (1998) Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837-853