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Volumn 3, Issue 3, 2008, Pages 319-329

In vitro exposure systems and bioassays for the assessment of toxicity of nanoparticles to the human lung

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA;

EID: 52949114905     PISSN: 16615751     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00003-008-0356-2     Document Type: Article
Times cited : (36)

References (66)
  • 1
    • 0034129391 scopus 로고    scopus 로고
    • Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: A study with a new cell exposure system to freshly generated DE in vitro
    • Abe, S., Takizawa, H., Sugawara, I., and Kudoh, S. (2000) Diesel exhaust (DE)-induced cytokine expression in human bronchial epithelial cells: a study with a new cell exposure system to freshly generated DE in vitro. Am J Respir Cell Mol Biol 22:296-303.
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 296-303
    • Abe, S.1    Takizawa, H.2    Sugawara, I.3    Kudoh, S.4
  • 2
    • 33947599134 scopus 로고    scopus 로고
    • Gene expression modulation in A549 human lung cells in response to combustion-generated nano-sized particles
    • Arenz, A., Hellweg, C. E., Stojicic, N., Baumstark-Khan, C., and Grotheer, H. H. (2006) Gene expression modulation in A549 human lung cells in response to combustion-generated nano-sized particles. Ann N Y Acad Sci 1091:170 -183.
    • (2006) Ann N Y Acad Sci , vol.1091 , pp. 170-183
    • Arenz, A.1    Hellweg, C.E.2    Stojicic, N.3    Baumstark-Khan, C.4    Grotheer, H.H.5
  • 5
    • 21244486183 scopus 로고    scopus 로고
    • Direct exposure methods for testing native atmospheres
    • Aufderheide, M. (2005) Direct exposure methods for testing native atmospheres. Exp Toxicol Pathol 57 Suppl 1:213-226.
    • (2005) Exp Toxicol Pathol , vol.57 , Issue.SUPPL. 1 , pp. 213-226
    • Aufderheide, M.1
  • 6
    • 0033381752 scopus 로고    scopus 로고
    • CULTEX - a new system and technique for the cultivation and exposure of cells at the air/ liquid interface
    • Aufderheide, M., and Mohr, U. (1999) CULTEX - a new system and technique for the cultivation and exposure of cells at the air/ liquid interface. Exp Toxicol Pathol 51:489-490.
    • (1999) Exp Toxicol Pathol , vol.51 , pp. 489-490
    • Aufderheide, M.1    Mohr, U.2
  • 8
    • 4444340696 scopus 로고    scopus 로고
    • Exposure of differentiated airway epithelial cells to volatile smoke in vitro
    • Beisswenger, C., Platz, J., Seifart, C., Vogelmeier, C., and Bals, R. (2004) Exposure of differentiated airway epithelial cells to volatile smoke in vitro. Respiration 71:402-409.
    • (2004) Respiration , vol.71 , pp. 402-409
    • Beisswenger, C.1    Platz, J.2    Seifart, C.3    Vogelmeier, C.4    Bals, R.5
  • 10
    • 5444256855 scopus 로고    scopus 로고
    • Effects of nanophase materials (< or = 20 nm) on biological responses
    • Cheng, M. D. (2004) Effects of nanophase materials (< or = 20 nm) on biological responses. J Environ Sci Health A Tox Hazard Subst Environ Eng 39:2691-2705.
    • (2004) J Environ Sci Health A Tox Hazard Subst Environ Eng , vol.39 , pp. 2691-2705
    • Cheng, M.D.1
  • 11
    • 0142212429 scopus 로고    scopus 로고
    • Monitoring cellular responses of engine-emitted particles by using a direct air-cell interface deposition technique
    • Cheng, M. D., Malone, B., and Storey, J. M. E. (2003) Monitoring cellular responses of engine-emitted particles by using a direct air-cell interface deposition technique. Chemosphere 53:237-243.
    • (2003) Chemosphere , vol.53 , pp. 237-243
    • Cheng, M.D.1    Malone, B.2    Storey, J.M.E.3
  • 13
    • 49449085976 scopus 로고    scopus 로고
    • Response of a co-culture lung model to fine and ultrafine particles of incinerator fly ash at the air-liquid interface
    • in press
    • Diabaté, S., Mülhopt, S., Paur, H. R., and Krug, H. F. (2008) Response of a co-culture lung model to fine and ultrafine particles of incinerator fly ash at the air-liquid interface. Altern Lab Anim (in press).
    • (2008) Altern Lab Anim
    • Diabaté, S.1    Mülhopt, S.2    Paur, H.R.3    Krug, H.F.4
  • 16
    • 0027253620 scopus 로고
    • In vitro acute effects of tobacco smoke on tumor necrosis factor alpha and interleukin-6 production by alveolar macrophages
    • Dubar, V., Gosset, P., Aerts, C., Voisin, C., Wallaert, B., and Tonnel, A. B. (1993) In vitro acute effects of tobacco smoke on tumor necrosis factor alpha and interleukin-6 production by alveolar macrophages. Exp Lung Res 19:345-359.
    • (1993) Exp Lung Res , vol.19 , pp. 345-359
    • Dubar, V.1    Gosset, P.2    Aerts, C.3    Voisin, C.4    Wallaert, B.5    Tonnel, A.B.6
  • 17
    • 0032531145 scopus 로고    scopus 로고
    • Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism
    • Foster, K. A., Oster, C. G., Mayer, M. M., Avery, M. L., and Audus, K. L. (1998) Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 243:359-366.
    • (1998) Exp Cell Res , vol.243 , pp. 359-366
    • Foster, K.A.1    Oster, C.G.2    Mayer, M.M.3    Avery, M.L.4    Audus, K.L.5
  • 18
    • 1842420453 scopus 로고    scopus 로고
    • Modified procedure of a direct in vitro exposure system for mammalian cells to whole cigarette smoke
    • Fukano, Y., Ogura, M., Eguchi, K., Shibagaki, M., and Suzuki, M. (2004) Modified procedure of a direct in vitro exposure system for mammalian cells to whole cigarette smoke. Exp Toxicol Pathol 55317-323.
    • (2004) Exp Toxicol Pathol , pp. 55317-55323
    • Fukano, Y.1    Ogura, M.2    Eguchi, K.3    Shibagaki, M.4    Suzuki, M.5
  • 19
    • 33745168299 scopus 로고    scopus 로고
    • Heme oxygenase-1 gene expression in human alveolar epithelial cells (A549) following exposure to whole cigarette smoke on a direct in vitro exposure system
    • Fukano, Y., Yoshimura, H., and Yoshida, T. (2006) Heme oxygenase-1 gene expression in human alveolar epithelial cells (A549) following exposure to whole cigarette smoke on a direct in vitro exposure system. Exp Toxicol Pathol 57:411-418.
    • (2006) Exp Toxicol Pathol , vol.57 , pp. 411-418
    • Fukano, Y.1    Yoshimura, H.2    Yoshida, T.3
  • 20
    • 0043094105 scopus 로고    scopus 로고
    • Formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black
    • Gallagher, J., Sams, R., Inmon, J., Gelein, R., Elder, A., Oberdörster, G., and Prahalad, A. K. (2003) Formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine in rat lung DNA following subchronic inhalation of carbon black. Toxicol Appl Pharmacol 190:224-231.
    • (2003) Toxicol Appl Pharmacol , vol.190 , pp. 224-231
    • Gallagher, J.1    Sams, R.2    Inmon, J.3    Gelein, R.4    Elder, A.5    Oberdörster, G.6    Prahalad, A.K.7
  • 21
    • 0035883840 scopus 로고    scopus 로고
    • Effects of phospholipid surfactant on apoptosis induction by respirable quartz and kaolin in NR8383 rat pulmonary macrophages
    • Gao, N., Keane, M. J., Ong, T., Ye, J., Miller, W. E., and Wallace, W. E. (2001) Effects of phospholipid surfactant on apoptosis induction by respirable quartz and kaolin in NR8383 rat pulmonary macrophages. Toxicol Appl Pharmacol 175:217-225.
    • (2001) Toxicol Appl Pharmacol , vol.175 , pp. 217-225
    • Gao, N.1    Keane, M.J.2    Ong, T.3    Ye, J.4    Miller, W.E.5    Wallace, W.E.6
  • 23
    • 0032874845 scopus 로고    scopus 로고
    • Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
    • Hayes, J. D., and McLellan, L. I. (1999) Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress. Free Radic Res 31:273-300.
    • (1999) Free Radic Res , vol.31 , pp. 273-300
    • Hayes, J.D.1    McLellan, L.I.2
  • 24
    • 0344404321 scopus 로고    scopus 로고
    • In vitro effects of nitrogen dioxide on the release of nitric oxide by bovine alveolar macrophages
    • Höckele, V., Krüger, E., Krug, H. F., and Seidel, A. (1998) In vitro effects of nitrogen dioxide on the release of nitric oxide by bovine alveolar macrophages. Toxicol Lett 96-97:53-57.
    • (1998) Toxicol Lett , vol.96-97 , pp. 53-57
    • Höckele, V.1    Krüger, E.2    Krug, H.F.3    Seidel, A.4
  • 25
    • 0344010499 scopus 로고    scopus 로고
    • Air exposure causes oxidative stress in cultured bovine tracheal epithelial cells and produces a change in cellular glutathione systems
    • Kameyama, S., Kondo, M., Takeyama, K., and Nagai, A. (2003) Air exposure causes oxidative stress in cultured bovine tracheal epithelial cells and produces a change in cellular glutathione systems. Exp Lung Res 29:567-583.
    • (2003) Exp Lung Res , vol.29 , pp. 567-583
    • Kameyama, S.1    Kondo, M.2    Takeyama, K.3    Nagai, A.4
  • 27
    • 0028534891 scopus 로고
    • Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro
    • Kinnula, V. L., Yankaskas, J. R., Chang, L., Virtanen, I., Linnala, A., Kang, B. H., and Crapo, J. D. (1994) Primary and immortalized (BEAS 2B) human bronchial epithelial cells have significant antioxidative capacity in vitro. Am J Respir Cell Mol Biol 11:568-576.
    • (1994) Am J Respir Cell Mol Biol , vol.11 , pp. 568-576
    • Kinnula, V.L.1    Yankaskas, J.R.2    Chang, L.3    Virtanen, I.4    Linnala, A.5    Kang, B.H.6    Crapo, J.D.7
  • 28
    • 0030641376 scopus 로고    scopus 로고
    • Increased oxidative metabolism in cow tracheal epithelial cells cultured at air-liquid interface
    • Kondo, M., Tamaoki, J., Sakai, A., Kameyama, S., Kanoh, S., and Konno, K. (1997) Increased oxidative metabolism in cow tracheal epithelial cells cultured at air-liquid interface. Am J Respir Cell Mol Biol 16:62-68.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 62-68
    • Kondo, M.1    Tamaoki, J.2    Sakai, A.3    Kameyama, S.4    Kanoh, S.5    Konno, K.6
  • 29
    • 52949095043 scopus 로고    scopus 로고
    • Strategie zur Minimierung von Tierversuchen unter REACH.
    • Lahl, U. (2005) Strategie zur Minimierung von Tierversuchen unter REACH. StoffR 6:251-262.
    • (2005) StoffR , vol.6 , pp. 251-262
    • Lahl, U.1
  • 30
    • 0033786099 scopus 로고    scopus 로고
    • Toxicity of diesel engine exhausts in an in vitro model of lung slices in biphasic organotypic culture: Induction of a proinflammatory and apoptotic response
    • Le Prieur, E., Vaz, E., Bion, A., Dionnet, F., and Morin, J. P. (2000) Toxicity of diesel engine exhausts in an in vitro model of lung slices in biphasic organotypic culture: induction of a proinflammatory and apoptotic response. Arch Toxicol 74:460-466.
    • (2000) Arch Toxicol , vol.74 , pp. 460-466
    • Le Prieur, E.1    Vaz, E.2    Bion, A.3    Dionnet, F.4    Morin, J.P.5
  • 32
    • 0037108605 scopus 로고    scopus 로고
    • Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages
    • Li, N., Wang, M., Oberley, T. D., Sempf, J. M., and Nel, A. E. (2002) Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol 169:4531-4541.
    • (2002) J Immunol , vol.169 , pp. 4531-4541
    • Li, N.1    Wang, M.2    Oberley, T.D.3    Sempf, J.M.4    Nel, A.E.5
  • 33
    • 0344404322 scopus 로고    scopus 로고
    • A new coculture-system of bronchial epithelial and endothelial cells as a model for studying ozone effects on airway tissue
    • Mögel, M., Krüger, E., Krug, H. F., and Seidel, A. (1998) A new coculture-system of bronchial epithelial and endothelial cells as a model for studying ozone effects on airway tissue. Toxicol Lett 96-97:25-32.
    • (1998) Toxicol Lett , vol.96-97 , pp. 25-32
    • Mögel, M.1    Krüger, E.2    Krug, H.F.3    Seidel, A.4
  • 35
    • 84885754789 scopus 로고    scopus 로고
    • In vitro testing of inhalable fly ash at the air liquid interface
    • Kim, Y. J, and Piatt, U, eds, Springer Netherlands, pp
    • Mülhopt, S., Paur, H. R., Diabaté, S., and Krug, H. F. (2007) In vitro testing of inhalable fly ash at the air liquid interface. In: Kim, Y. J., and Piatt, U. (eds.) Advanced Environmental Monitoring. Springer Netherlands, pp. 402-414.
    • (2007) Advanced Environmental Monitoring , pp. 402-414
    • Mülhopt, S.1    Paur, H.R.2    Diabaté, S.3    Krug, H.F.4
  • 36
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel, A., Xia, T., Madler, L., and Li, N. (2006) Toxic potential of materials at the nanolevel. Science 311:622-627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 37
    • 0029021139 scopus 로고
    • Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells
    • Nichols, W. K., Terry, C. M., Cutler, N. S., Appleton, M. L., Jesthi, P. K., and Yost, G. S. (1995) Oxidation at C-1 controls the cytotoxicity of 1,1-dichloro-2,2- bis(p-chlorophenyl)ethane by rabbit and human lung cells. Drug Metab Dispos 23:595-599.
    • (1995) Drug Metab Dispos , vol.23 , pp. 595-599
    • Nichols, W.K.1    Terry, C.M.2    Cutler, N.S.3    Appleton, M.L.4    Jesthi, P.K.5    Yost, G.S.6
  • 38
    • 33845214358 scopus 로고    scopus 로고
    • Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., Olin, S., Monteiro-Riviere, N., Warheit, D., and Yang, H. (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials : elements of a screening strategy. Part Fibre. Toxicol 2:8. OECD:http://titania.sourceoecd.org/vl=9147379/cl=14/nw=l/ rpsv/cw/vhosts/ oecdjoumals/1607310x/vln4/contp1-1.htm
    • Oberdörster, G., Maynard, A., Donaldson, K., Castranova, V., Fitzpatrick, J., Ausman, K., Carter, J., Karn, B., Kreyling, W., Lai, D., Olin, S., Monteiro-Riviere, N., Warheit, D., and Yang, H. (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials : elements of a screening strategy. Part Fibre. Toxicol 2:8. OECD:http://titania.sourceoecd.org/vl=9147379/cl=14/nw=l/ rpsv/cw/vhosts/ oecdjoumals/1607310x/vln4/contp1-1.htm
  • 39
    • 52949153616 scopus 로고    scopus 로고
    • OECD, Guidelines
    • OECD - Guidelines: http://flordiliji.sourceoecd.org/vl=2571690/cl=65/ nw=l/rpsv/cw/vhosts/oecdjournals/1607310x/vln4/contpl-1.htm
  • 40
    • 21844451174 scopus 로고    scopus 로고
    • Exposure of bronchial epithelial cells to whole cigarette smoke: Assessment of cellular responses
    • Phillips, J., Kluss, B., Richter, A., and Massey, E. (2005) Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses. Altern Lab Anim 33:239-248.
    • (2005) Altern Lab Anim , vol.33 , pp. 239-248
    • Phillips, J.1    Kluss, B.2    Richter, A.3    Massey, E.4
  • 41
    • 52949086838 scopus 로고    scopus 로고
    • Piekarski, C. (2006) Feinstäube als Herausforderung für die Industrie - Eine historische Zeitreise durch die Welt des Bergbaus. In: econsense - Forum Nachhaltige Entwicklung der Deutschen Wirtschaft e.V. (ed.) Herausforderung Feinstaub - Wissen-schaftliche Beiträge des Instituts für Arbeitswissenschaften der RAG Aktiengesellschaft.
    • Piekarski, C. (2006) Feinstäube als Herausforderung für die Industrie - Eine historische Zeitreise durch die Welt des Bergbaus. In: econsense - Forum Nachhaltige Entwicklung der Deutschen Wirtschaft e.V. (ed.) Herausforderung Feinstaub - Wissen-schaftliche Beiträge des Instituts für Arbeitswissenschaften der RAG Aktiengesellschaft.
  • 42
    • 0037029043 scopus 로고    scopus 로고
    • Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air polution
    • Pope, C. A., Burnett, R. T., Thun, M. J., Calle, E. E., Krewski, D., Ito, K., and Thurston, G. D. (2002) Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air polution. Am Med Assoc 287:1132-1141.
    • (2002) Am Med Assoc , vol.287 , pp. 1132-1141
    • Pope, C.A.1    Burnett, R.T.2    Thun, M.J.3    Calle, E.E.4    Krewski, D.5    Ito, K.6    Thurston, G.D.7
  • 43
    • 52949122168 scopus 로고    scopus 로고
    • Pott, F., and Roller, M. (2003) Untersuchungen zur Kanzerogenität granulärer Stäube an Ratten - Ergebnisse und Interpretationen. Kurzbericht über das Projekt F1843 der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, veröffentlicht am 28.08.2003 im Internet unter http://www.baua.de/fors/fl843.
    • Pott, F., and Roller, M. (2003) Untersuchungen zur Kanzerogenität granulärer Stäube an Ratten - Ergebnisse und Interpretationen. Kurzbericht über das Projekt F1843 der Bundesanstalt für Arbeitsschutz und Arbeitsmedizin, veröffentlicht am 28.08.2003 im Internet unter http://www.baua.de/fors/fl843.
  • 45
    • 0033806242 scopus 로고    scopus 로고
    • Oxidative stress and regulation of glutathione in lung inflammation
    • Rahman, I., and MacNee, W. (2000) Oxidative stress and regulation of glutathione in lung inflammation. Eur Respir J 16:534-554.
    • (2000) Eur Respir J , vol.16 , pp. 534-554
    • Rahman, I.1    MacNee, W.2
  • 47
    • 16444371242 scopus 로고    scopus 로고
    • A three-dimensional cellular model of the human respiratory tract to study the interaction with particles
    • Rothen-Rutishauser, B. M., Kiama, S. G., and Gehr, P. (2005) A three-dimensional cellular model of the human respiratory tract to study the interaction with particles. Am J Respir Cell Mol Biol 32:281-289.
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 281-289
    • Rothen-Rutishauser, B.M.1    Kiama, S.G.2    Gehr, P.3
  • 48
    • 0029909519 scopus 로고    scopus 로고
    • Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium
    • Rusznak, C., Devalia, J. L., Sapsford, R. J., and Davies, R. J. (1996) Ozone-induced mediator release from human bronchial epithelial cells in vitro and the influence of nedocromil sodium. Eur Respir J 9:2298-2305.
    • (1996) Eur Respir J , vol.9 , pp. 2298-2305
    • Rusznak, C.1    Devalia, J.L.2    Sapsford, R.J.3    Davies, R.J.4
  • 52
    • 2342663701 scopus 로고    scopus 로고
    • Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1
    • Sheets, P. L., Yost, G. S., and Carlson, G. P. (2004) Benzene metabolism in human lung cell lines BEAS-2B and A549 and cells overexpressing CYP2F1. J Biochem Mol Toxicol 18:92-99.
    • (2004) J Biochem Mol Toxicol , vol.18 , pp. 92-99
    • Sheets, P.L.1    Yost, G.S.2    Carlson, G.P.3
  • 53
    • 0017367571 scopus 로고
    • Cell line A549: A model system for the study of alveolar type II cell function
    • Smith, B. T. (1977) Cell line A549: a model system for the study of alveolar type II cell function. Am Rev Respir Dis 115:285-293.
    • (1977) Am Rev Respir Dis , vol.115 , pp. 285-293
    • Smith, B.T.1
  • 55
    • 21344471653 scopus 로고    scopus 로고
    • Cell culture models of the respiratory tract relevant to pulmonary drug delivery
    • Steimer, A., Haltner, E., and Lehr, C. M. (2005) Cell culture models of the respiratory tract relevant to pulmonary drug delivery. J Aerosol Med 18:137-182.
    • (2005) J Aerosol Med , vol.18 , pp. 137-182
    • Steimer, A.1    Haltner, E.2    Lehr, C.M.3
  • 56
    • 0036009467 scopus 로고    scopus 로고
    • Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release
    • Tao, F., and Kobzik, L. (2002) Lung macrophage-epithelial cell interactions amplify particle-mediated cytokine release. Am J Respir Cell Mol Biol 26:499-505.
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 499-505
    • Tao, F.1    Kobzik, L.2
  • 57
    • 33846500915 scopus 로고    scopus 로고
    • Particle kinetics in vitro: Dosimetry considerations for in vitro nanoparticle toxicity assessments
    • Teeguarden, J. G., Hinderliter, P. M., Orr, G., Thrall, B. D., and Pounds, J. G. (2007) Particle kinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments. Toxicol Sci 95:300-312.
    • (2007) Toxicol Sci , vol.95 , pp. 300-312
    • Teeguarden, J.G.1    Hinderliter, P.M.2    Orr, G.3    Thrall, B.D.4    Pounds, J.G.5
  • 58
    • 0036132641 scopus 로고    scopus 로고
    • Deposition of fine and ultrafine aerosol particles during exposure at the air/cell interface
    • Tippe, A., Heinzmann, U., and Roth, C. (2002) Deposition of fine and ultrafine aerosol particles during exposure at the air/cell interface. J Aerosol Sci 33:207-218.
    • (2002) J Aerosol Sci , vol.33 , pp. 207-218
    • Tippe, A.1    Heinzmann, U.2    Roth, C.3
  • 61
    • 0026641567 scopus 로고
    • In vitro study of gas effects on alveolar macrophages
    • Wallaert, B., and Voisin, C. (1992) In vitro study of gas effects on alveolar macrophages. Cell Biol Toxicol 8:151-156.
    • (1992) Cell Biol Toxicol , vol.8 , pp. 151-156
    • Wallaert, B.1    Voisin, C.2
  • 63
    • 0023765835 scopus 로고
    • A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells
    • Whitcutt, M. J., Adler, K. B., and Wu, R. (1988) A biphasic chamber system for maintaining polarity of differentiation of cultured respiratory tract epithelial cells. In Vitro Cell Dev Biol 24:420-428.
    • (1988) In Vitro Cell Dev Biol , vol.24 , pp. 420-428
    • Whitcutt, M.J.1    Adler, K.B.2    Wu, R.3
  • 64
    • 52949121435 scopus 로고    scopus 로고
    • Wottrich, R. (2003) Zur toxikologischen Untersuchung ultrafeiner Partikel: Entwicklung und Einsatz eines realitätsnahen in vitro Lungenmodells. Thesis, Universität Karlsruhe.
    • Wottrich, R. (2003) Zur toxikologischen Untersuchung ultrafeiner Partikel: Entwicklung und Einsatz eines realitätsnahen in vitro Lungenmodells. Thesis, Universität Karlsruhe.
  • 65
    • 4544255267 scopus 로고    scopus 로고
    • Biological effects of ultrafine model particles in human macrophages and epithelial cells in mono- and co-culture
    • Wottrich, R., Diabaté, S., and Krug, H. F. (2004) Biological effects of ultrafine model particles in human macrophages and epithelial cells in mono- and co-culture. Int J Hyg Environ Health 207:353-361.
    • (2004) Int J Hyg Environ Health , vol.207 , pp. 353-361
    • Wottrich, R.1    Diabaté, S.2    Krug, H.F.3
  • 66
    • 0022852944 scopus 로고
    • An in vitro model for the exposure of lung alveolar epithelial cells to toxic gases
    • Zamora, P. O., Gregory, R. E., Li, A. P., and Brooks, A. L. (1986) An in vitro model for the exposure of lung alveolar epithelial cells to toxic gases. J Environ Pathol Toxicol Oncol 7:159-168.
    • (1986) J Environ Pathol Toxicol Oncol , vol.7 , pp. 159-168
    • Zamora, P.O.1    Gregory, R.E.2    Li, A.P.3    Brooks, A.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.