Enhancement of Trk signaling pathways by the cholestane amide conjugate MCC-257

Journal of Pharmacological Sciences

Volumn 108, Issue 1, 2008, Pages 131-134

  Yamada, Maki K ^a   Konishi, Yoshiyuki ^a   Kakinoki, Bunpei ^b   Ikegami, Koji ^a   Setou, Mitsutoshi ^a,c  

^a MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^b MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Lipid; Neurotrophin; Survival

Indexed keywords

CHOLESTANE AMIDE CONJUGATE; CHOLESTANE DERIVATIVE; MCC 257; MITOGEN ACTIVATED PROTEIN KINASE; N (5ALPHA CHOLESTAN 3ALPHA YL) 5 ACETAMIDO 3,5 DIDEOXY 2 O METHYL ALPHA DEXTRO GLYCERO DEXTRO GALACTO 2 NONULOPYRANOSONAMIDE; NERVE GROWTH FACTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; ENZYME PHOSPHORYLATION; IMMUNOBLOTTING; NONHUMAN; PHEOCHROMOCYTOMA CELL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

EID: 52949112205     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08109SC     Document Type: Article

References (13)

1. Arevalo JC, Conde B, Hempstead BL, Chao MV, Martin-Zanca D, Perez P. TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor. Mol Cell Biol. 2000;20:5908-5916.
2. Huang EJ, Reichardt LF. Trk receptors: roles in neuronal signal transduction. Annu Rev Biochem. 2003;72:609-642.
3. Valdez G, Philippidou P, Rosenbaum J, Akmentin W, Shao Y, Halegoua S. Trk-signaling endosomes are generated by Rac-dependent macroendocytosis. Proc Natl Acad Sci U S A. 2007; 104:12270-12275.
4. Pereira DB, Chao MV. The tyrosine kinase Fyn determines the localization of TrkB receptors in lipid rafts. J Neurosci. 2007;27:4859-4869.
5. Kuruvilla R, Ye H, Ginty DD. Spatially and functionally distinct roles of the PI3-K effector pathway during NGF signaling in sympathetic neurons. Neuron. 2000;27:499-512.
6. Suzuki S, Numakawa T, Shimazu K, Koshimizu H, Hara T, Hatanaka H, et al. BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol. 2004;167:1205-1215.
7. Ito H, Nomoto H, Furukawa S. Growth arrest of PC12 cells by nerve growth factor is dependent on the phosphatidylinositol 3-kinase/Akt pathway via p75 neurotrophin receptor. J Neurosci Res. 2003;72:211-217.
8. Kakinoki B, Sekimoto S, Yuki S, Ohgami T, Sejima M, Yamagami K, et al. Orally active neurotrophin-enhancing agent protects against dysfunctions of the peripheral nerves in hyperglycemic animals. Diabetes. 2006;55:616-621.
9. Ikegami K, Mukai M, Tsuchida J, Heier RL, Macgregor GR, Setou M. TTLL7 is a mammalian beta-tubulin polyglutamylase required for growth of MAP2-positive neurites. J Biol Chem. 2006;281:30707-30716.
10. Chen J, Kitanishi T, Ikeda T, Matsuki N, Yamada MK. Contextual learning induces an increase in the number of hippocampal CA1 neurons expressing high levels of BDNF. Neurobiol Learn Mem. 2007;88:409-415.
11. Marsh HN, Dubreuil CI, Quevedo C, Lee A, Majdan M, Walsh GS, et al. SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol. 2003;163:999-1010.
12. Guirland C, Suzuki S, Kojima M, Lu B, Zheng JQ. Lipid rafts mediate chemotropic guidance of nerve growth cones. Neuron. 2004;42:51-62.
13. Yamazaki Y, Horibata Y, Nagatsuka Y, Hirabayashi Y, Hashikawa T. Fucoganglioside alpha-fucosyl(alpha-galactosyl)-GM1: a novel member of lipid membrane microdomain components involved in PC12 cell neuritogenesis. Biochem J. 2007; 407:31-40.