Synthesis and biological evaluation of caulibugulones A-E

Organic and Biomolecular Chemistry

Volumn 2, Issue 15, 2004, Pages 2173-2174

  Wipf, Peter ^a   Joo, Beomjun ^a   Nguyen, Theresa ^b   Lazo, John S ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMMONIA; ASSAYS; CHROMATOGRAPHY; CYTOLOGY; ETHANOL; HALOGENATION; ORGANIC SOLVENTS; PROTEINS; SYNTHESIS (CHEMICAL); TUMORS;

BIOLOGICAL EVALUATION; CYTOTOXICITY ASSAYS; REGIOSELECTIVE HALOGENATIONS; TUMOR CELLS;

METABOLITES;

BRYOZOA; GYMNOLAEMATA;

ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE; QUINONE DERIVATIVE;

ANIMAL; ARTICLE; BRYOZOA; CELL CULTURE; CHEMISTRY; DRUG ANTAGONISM; EVALUATION; HUMAN; IC 50; METABOLISM; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BRYOZOA; CDC25 PHOSPHATASE; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; ISOQUINOLINES; QUINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 4344714386     PISSN: 14770520     EISSN: None     Source Type: Journal    
DOI: 10.1039/b408184f     Document Type: Article

References (16)

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9. 1H NMR.
10. 13C NMR spectra matched well with the reported spectra.
11. The regiochemistry of caulibugulone E was confirmed by analysis of the HMBC spectrum.
12. 2 Fluorescence emission from the product was measured after a 20 or 60 min incubation period at ambient temperature with a multiwell plate reader (PerSeptive Biosystems Cytofluor II; Framingham, MA; excitation filter, 485 nm/bandwidth 20 nm; emission filter, 530 nm/bandwidth 30 nm).
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